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E. Simko WCVM

PTT slides: *

References: General: Thomson's Special Veterinary Pathology W. W. Carlton et. al. Special: Muller & Kirk's Small Animal Dermatology D. W. Scott et. al Canine & Feline Dermatology G. H. Nesbitt and L. J. Ackerman Large Animal Dermatology D. W. Scott E. Simko WCVM

Dermis Epidermis Primary hair Secondary hair Superficial plexus Elector pili muscle Sebaceous gland Middle plexus Deep plexus Sweat gland E. Simko WCVM Subcutis

Infundibulum Isthmus Inferior segment Hair bulb Dermal papilla Hair Anatomy E. Simko WCVM

Stratum basale Basment membrane Stratum spinosum Stratum cornium Stratum granulosum Hemidesmosomes Desmosomes E. Simko WCVM Anatomy

Anatomy - Epidermis E. Simko WCVM Melanocytes Langerhans cells Merkel cells Lymphocytes

Exogenous Factors: Infectious Nutritional Allergic Physical Chemical Endogenous Factors: Immunologic Hereditary Congenital Hormonal Metabolic Emotional Internal dz Age E. Simko WCVM

Response to injury Orthokeratotic Hyperkeratosis Idiopathic seborrhea Ichtiosis Vitamin A deficiency E. Simko WCVM

Zinc-responsive dermatosis Hepatocutaneous syndrome E. Simko WCVM Parakeratotic Hyperkeratosis Response to injury

Irregular Regular Papillated Pseudocarcinomatous E. Simko WCVM Response to injury

Response to injury - Hyperplasia Pseudocarcin omatous PapillatedRegular Irregular Normal Hyperplasia Atrophy/ Hypoplasia Normal Aplasia E. Simko WCVM

Response to injury Hyperpigmentation Endocrine diseases Chronic inflammation E. Simko WCVM

Dermis Epidermis Response to injury Hypopigmentation Hereditary/Congenital Aquired with pigmentary incontinence E. Simko WCVM

Physiologic Pathologic (Programmed cell death) cell death initiating inflammation E. Simko WCVM Response to injury

Intercellular (Spongiosis) Non specific inflammatory change E. Simko WCVM Response to injury

Intracellular Edema Vacuolar degeneration Hydropic degeneration Balooning degeneration E. Simko WCVM Response to injury

Vesicle/pustule formation (Autoimmune dz) Reticular degeneration (Viral diseases) E. Simko WCVM Response to injury

E. Simko WCVM Autoimmune dz Pyoderma Response to injury Acanthocyte

E. Simko WCVM Exocytosis Pustule Crust (serous hemorrhgic, cellular) Response to injury

E. Simko WCVM Atrophy Inflammation and fibrosis Depositions Response to injury

E. Simko WCVM Atrophy Physiologic Pathologic Response to injury

Anagen Telogen Catagen Controlled by: daylight hours environment genetic factors hormones Modified from Applied Veterinary Histology, W.J.Banks

Modified from Applied Veterinary Histology, W.J.Banks and Small Animal Dermatology, D.W. Scott AnagenTelogen Response to injury

Superficial folliculitis Deep folliculitis Furunculosis Adenitis E. Simko WCVM Response to injury