Nuclear Weapons: The Final Pandemic Preventing Proliferation and Achieving Abolition Changing views of the biological effects of low-level ionizing radiation.

Slides:

Advertisements

Similar presentations

Ultrasonography survey and thyroid cancer in Fukushima Prefecture Peter Jacob, Alexander Ulanovsky, Christian Kaiser Department of Radiation Sciences Institute.

Advertisements

Wellbeing and its determinants CSP Congress 2009 Liverpool 16 October 2009.

EPA Radiogenic Cancer Risk Projections for the U.S. Population Michael Boyd Radiation Protection Division U.S. Environmental Protection Agency 2011 OAS.

NE Introduction to Nuclear Science Spring 2012 Classroom Session 9: Radiation Interaction with Matter  Absorbed Dose (D), Kerma (K) Gray (Gy) =

HEALTH CONSEQUENCES OF AND LESSONS LEARNED FROM MEDICAL RESPONSE TO SELECTED RADIATION ACCIDENTS Module XIXChernobyl.

Radiation Carcinogenesis Martin Brown. Two types of late effects of irradiation Deterministic (non-stochastic) effects –Severity increases with dose.

Childhood Thyroid Cancer in Russia Following the Chernobyl accident V.K. Ivanov Chairman, Russian Scientific Commission on Radiological Protection Medical.

Is low-dose Aspirin use associated with a reduced risk of colorectal cancer ? a QResearch primary care database analysis Prof Richard Logan, Dr Yana Vinogradova,

International Atomic Energy Agency What Radiation Effects are Possible? (besides skin injuries) L3.

The health risks of low-dose ionizing radiation Abel Russ Community-Based Hazard Management Program George Perkins Marsh Institute Clark University.

From X-rays to Cordless Phones: Radiation Causes Brain Tumors Lloyd Morgan.

BEIR VII: “The very error of the moon.” Othello, Act II Herbert L. Abrams.

Alexander Brandl ERHS 630 Effective and Committed Effective Dose Environmental and Radiological Health Sciences.

Cancer Statistics 2013 A Presentation from the American Cancer Society

Biological Effects of Ionizing Radiation Stochastic Somatic Effects Radiation induction of cancer Lecture IAEA Post Graduate Educational Course Radiation.

Diabetes Disparities & Its Effects on Minority Populations Appathurai Balamurugan, MD, MPH Section Chief, Chronic Disease Epidemiology, ADHHS Assistant.

DIABETES AMONG AMERICAN INDIANS: A CASE STUDY IN MOVING FROM HEALTH DISPARITIES TO HEALTH EQUITY Ronny A. Bell, PhD, MS Professor, Department of Epidemiology.

Radiation Dose Limits for Adult Subjects Henry D. Royal, M.D. Associate Director Division of Nuclear Medicine Mallinckrodt Institute of Radiology Professor.

Thyroid Disease among A-bomb Survivors Exposed in Childhood Roy Shore, Kyoji Furukawa, Misa Imaizumi Radiation Effects Research Foundation

Cancer Statistics 2013 A Presentation from the American Cancer Society

Induction and latency (J-F Boivin, March 2006) 1.Introduction 2.Rothman’s model of induction 3.Analysis: largest estimate methods 4.Modelling approaches.

Radiation Dose in MS-CT coronarography Ladislav Pavic, MD, PhD Sunce Clinics Zagreb / Sarajevo Croatia / Bosnia & Herzegovina.

Anthony Waker Faculty of Energy Systems and Nuclear Science.

Effects of Low Doses Probability of Causation and implications for Public Policy Lecture at UC Berkeley March 2nd 2001 by Richard Wilson Mallinckrodt Research.

Kjell Hansson Mild There has been much debate in the media if young persons might be more sensitive to microwave emissions from cellular phones than older.

 2011 Johns Hopkins Bloomberg School of Public Health Jonathan M. Samet, MD, MS Director, USC Institute for Global Health Professor and Flora L. Thornton.

Measures of Association

Deconstructing Linearity Kenneth L. Mossman Professor of Health Physics Director, Office of Radiation Safety Arizona State University Tempe, AZ.

Health Effects of Radiation. What Radiation Affects Directly or indirectly, radiation affects the DNA in cells DNA controls the cell’s function and ability.

Joint Effects of Radiation and Smoking on Lung Cancer Risk among Atomic Bomb Survivors Donald A. Pierce, RERF Gerald B. Sharp, RERF & NIAID Kiyohiko Mabuchi,

Radiation effects on cancer risks in atomic bomb survivors Chelyabinsk October 2, 2012 Dale L. Preston Hirosoft International Eureka, CA.

Radiation Health Effects

Beyond Dose Assessment Using Risk with Full Disclosure of Uncertainty in Public and Scientific Communication F. Owen Hoffman, David C. Kocher and A. Iulian.

ANALYTICAL X-RAY SAFETY User Training Centre for Environmental Health, Safety and Security Management.

Radiation and Cancer Risk A topical update with the best available data Donald E. Mosier MD PhD October 19, 2013 A topical update with the best available.

Quarterly HIV/AIDS Analysis for Michigan January 1, 2008 Michigan Department of Community Health HIV/STD/Viral Hepatitis and TB Epidemiology Section Division.

Edward Mills PhD, Associate Professor, Faculty of Health Sciences University of Ottawa AIDS Mortality Among Men in Africa: An overview of the evidence.

BEIR VII: Update on the risks of “low-level” radiation Overview of the main findings by Arjun Makhijani, Ph.D. President, Institute for Energy and Environmental.

TB epidemiology in Thailand Philippe Glaziou, on behalf of the epi team Bangkok, August 2013.

Biological Effects of Ionizing Radiation Stochastic Somatic Effects Radiation risk Lecture IAEA Post Graduate Educational Course Radiation Protection and.

Risk Assessment of Radiation-Induced Thyroid Cancer in Population of Belarus M.V.Malko Institute of Power National Academy of Sciences of Belarus, Minsk,

The International Workshop on Radiation and Thyroid Cancer (Day 2 ) Dose EstimationEffects Identification Dose Response Relationship Risk Estimation.

RADIATION PROTECTION IN RADIOTHERAPY

A short introduction to epidemiology Chapter 2: Incidence studies Neil Pearce Centre for Public Health Research Massey University Wellington, New Zealand.

Dale L. Preston Hirosoft International Eureka, CA Cancer Risks Following Low Dose Radiation Exposures: Lessons from Epi Studies The Accidents at Fukushima.

Date of download: 6/27/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Radiation Dose-Response Relationships for Thyroid.

DRPH/SRBE/LEPID Results of epidemiological studies Contribution from occupationally exposed populations to quantification of risk at low doses Margot Tirmarche.

The accidents at Fukushima Dai-Ichi Summary of Health Discussions

Relevance of the Chernobyl Research for the Evaluation of Genetic Radiation Risks in Humans Saint Petersburg 2015 Inge Schmitz-Feuerhake and Sebastian.

Figure 2. Dose distribution function for thyroid cancer cases and for healthy members of the cohort for adults (18 y of age and older at the time of the.

BEIR VII: Update on the risks of “low-level” radiation

Optimizing Outcomes With CT Imaging

TAIWAN Cobalt 60 contamination - doses

Volume 147, Issue 4, Pages (April 2015)

Induction and latency (J-F Boivin, March 2006)

Estimating the risk of solid organ malignancy in patients undergoing routine computed tomography scans after endovascular aneurysm repair Raghu Motaganahalli,

Late Effects of Radiation

Daniel Stram; University of Southern California

NYU School of Medicine (Retired)

EPA Perspectives on Risk Projections for Low Dose and Dose Rate Exposures David Pawel, Ph.D. Office of Radiation and Indoor Air (EPA) American Nuclear.

The Case for a Threshold Bennett S

Measures of risk and association

Prepared by staff in Prevention and Cancer Control.

Writing Committee Members et al. JACC 2018;j.jacc

Clinically significant precounseling cancer distress modifies counseling method's effect on testing uptake. *, statistically significant difference observed.

Answers to Common Questions About the Use and Safety of CT Scans

Thank you, Dr Greek. Good morning everyone

Writing Committee Members et al. JACC 2018;j.jacc

The pattern of association between all-cancer mortality risk and long-term exposure to PM2.5 (μg/m3). The pattern of association between all-cancer mortality.

Figure 1. Estimated weight functions (dotted-dashed lines) and pointwise 95% bootstrap confidence intervals (shaded ... Figure 1. Estimated weight functions.

Presentation transcript:

Nuclear Weapons: The Final Pandemic Preventing Proliferation and Achieving Abolition Changing views of the biological effects of low-level ionizing radiation Steve Wing Associate Professor of Epidemiology University of North Carolina School of Public Health

Brenner et al., 2003, Proceedings of the National Academy of Sciences

Lifetime Cumulative DoseDose at Ages 45+ Oak Ridge National Laboratory External Radiation and Cancer Deaths, Based on Richardson & Wing, Int J Epidemiol, 28: , 1999

Estimated association between cumulative radiation dose (3-yr lag) and mortality due to leukemia. LeukemiaLeukemia-CLLMyeloid Leukemia Males & Females ERR/10 mSv % CI-0.001, , , LRT (  2, 1 d.f.) Males only ERR/10 mSv % CI0.000, , , LRT (  2, 1 d.f.) Richardson & Wing, American Journal of Epidemiology, 2007

Time since exposure LeukemiaLeukemia-CLLMyeloid Leukemia 3-<15 years ERR/10 mSv % CI0.021, , 1.046<0, LRT (  2, 1 d.f.) <30 years ERR/10 mSv % CI<0, 0.109<0, 0.167<0, LRT (  2, 1 d.f.) years ERR/10 mSv % CI<0, 0.151<0, 0.458<0, LRT (  2, 1 d.f.) Association between mortality due to leukemia among male SRS workers and cumulative radiation dose accrued in 3 exposure time windows

15 country studyA-bomb survivors (men ages ATB) SRS study No. cancers ERR/Sv (90%CI) No. cancers ERR/Sv (90%CI) No. cancers ERR/Sv (90%CI) (<0, 7.14) * (1.79, 5.18) (1.40, 19.80) Excess relative risk per Sv for leukemia excluding CLL for A-bomb survivors, workers included in the IARC 15-country study, and for SRS workers * Derived via a linear ERR model adjusted for age, calendar period, and city

Alice Stewart’s model of exposure age and cancer risk Stewart, A. Environmental Health Perspectives, 108:93-96, 2000

Pierce et al. Radiation Research, 167: , 2007

Alternative Descriptions of Age-at-Exposure Effects on Solid Cancer Incidence, Life Span Study, Preston et al., Radiation Research, 168:1-64, 2007 age at exposure

Prevalence Odds Ratios for “Multifactorial Disease” in Relation to Parental Radiation Doses: Clinical Health Study of Children of A-bomb Survivors Relative odds per Gy, 95% CI Female offspringMale offspring Mother’s dose – – 1.17 Father’s dose – – 0.89 RERF, Report on the Health Effects Study of the Children of A-bomb Survivors, March, 2007

Source: US Department of Energy, Closing the Circle on the Splitting of the Atom, 1996