Clinical ‘Recovery’ by Day 4 vs Baseline Nimodipine Ischemic Stroke Neuroprotection Study 1985 Mathew Score (100 = intact) BaselineDay 4 Time from Onset.

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Presentation transcript:

Clinical ‘Recovery’ by Day 4 vs Baseline Nimodipine Ischemic Stroke Neuroprotection Study 1985 Mathew Score (100 = intact) BaselineDay 4 Time from Onset Total Cases Mathew > 95 Mathew > 95 < 6 hrs2502 < 12 hrs15002 < 18 hrs25005 < 24 hrs37308 < 48 hrs943015

Treatment Effect by Time of Rx Start Nimodipine Ischemic Stroke Neuroprotection Study 1985 Mathew Score (100 = intact) Covarient Adjusted Means Hours to RxMean ScoreStd ErrP vs < 18 hr <

Hrs Onset to Arrival &Neuro Exam NINDS MR/CT Study 1988 Interval#%Cum % < 1 hrs143.4 < 2 hrs < 3 hrs < 4 hrs < 6 hrs < 12 hr < 24 hr

tPA < 3 hrs Rxd per Month CPMC Aug-2000 to Oct-2002

Acute Stroke Admissions per Month CPMC Aug-2000 to Oct-2002

CPMC Consecutive Cases Aug-00/Oct-02 Hrs onset to arrival (green) then to tPA (red)

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