Prevention of graft-versus-host disease by anti–IL-7Rα antibody by Brile Chung, Eric P. Dudl, Dullei Min, Lora Barsky, Nancy Smiley, and Kenneth I. Weinberg.

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Presentation transcript:

Prevention of graft-versus-host disease by anti–IL-7Rα antibody by Brile Chung, Eric P. Dudl, Dullei Min, Lora Barsky, Nancy Smiley, and Kenneth I. Weinberg Blood Volume 110(8): October 15, 2007 ©2007 by American Society of Hematology

Blockade of IL-7R signaling by anti–IL-7Rα antibody can effectively prevent proliferation of an IL-7–dependent cell line. Brile Chung et al. Blood 2007;110: ©2007 by American Society of Hematology

Anti–IL-7Rα antibody treatment can successfully prevent GVHD-related mortality and morbidity following allogeneic BM transplantation. Brile Chung et al. Blood 2007;110: ©2007 by American Society of Hematology

Histologic analysis of anti–IL-7Rα antibody-treated allogeneic recipients. Brile Chung et al. Blood 2007;110: ©2007 by American Society of Hematology

Administration of anti–IL-7Rα antibody results in decreased numbers of donor T cells in the periphery following allogeneic BMT. Analyses of donor-derived peripheral CD4 and CD8 T-cell numbers in anti–IL-7Rα antibody and PBS-treated B6 recipients were perfor... Brile Chung et al. Blood 2007;110: ©2007 by American Society of Hematology

Administration of anti–IL-7Rα antibody results in decreased proliferation of donor-derived T cells. Brile Chung et al. Blood 2007;110: ©2007 by American Society of Hematology

Anti–IL-7Rα antibody treatment does not impair donor-derived thymopoiesis following allogeneic BMT. Both histologic features and donor-derived cell analysis of the thymus from recipient mice were analyzed at day 30 after BMT. Shown are representative thymus... Brile Chung et al. Blood 2007;110: ©2007 by American Society of Hematology

Anti–IL-7Rα antibody treatment results in increased anti-SRBC titer following immunization. Brile Chung et al. Blood 2007;110: ©2007 by American Society of Hematology