Histology Laboratories Molecules to Systems 2003 Compiled by James D. Jamieson, MD/PhD Thomas L. Lentz, MD No part of this image collection may be distributed outside of the Yale University Intranet.

Alberts, B. et al. Molecular Biology of the Cell. 4th Edition, Garland Science, New York, Gartner, L. P. and Hiatt, J. L. Color Atlas of Histology, Williams & Wilkins, Baltimore, Kerr, J. B. Atlas of Functional Histology. Mosby, London, Kessel, R. G. and Kardon, R. H. Tissues and Organs: a text-atlas of scanning electron microscopy. W. H. Freeman, San Francisco, Lentz, T. L. Cell Fine Structure. W. B. Saunders, Philadelphia, Lodish, H. et al. Molecular Cell Biology. W. H. Freeman, New York, Mizoguti, H. Color Slide Atlas of Histology. Nihon Shashin Shinbunsha, Tokyo. Young, B. and Heath, J. W. Wheater’s Functional Histology. Churchill Livingstone, Edinburgh, Micrographs taken by George Palade, Marilyn Farquhar, James D. Jamieson, Nicolai Simionescu, Maya Simionescu, David Castle, Thomas L. Lentz. Web Resources Cushing Library Educational Software/Cell Biology/Several Histology Resources Acknowledgements Sources of Micrographs, Diagrams and Figures

Connective Tissue and Cartilage Laboratory

Lineage of CT cells from stem cells Note: all CT cells can make all CT molecules

Loose (areolar) CT Collagen type I

Collagen fibrils Blood vessel Smooth muscle Fibroblasts

Collagen fibers Plasma cells Lymphocytes

Areolar (Loose) Connective Tissue

Dense CT Collagen type I

Dermis of Skin

Achilles Tendon Fibroblasts

Fibroblast EM: constitutive secretion

Collagen Fibers Fibroblasts

Collagen Fibrils - periodicity

Reticular Fibers Collagen type III

Lymph Node with Reticular Fibers

Elastic Fibers

Whole Mount of Mesentery: Elastic Fibers

Small Artery Elastic lamina

Aorta: elastic fibers

Ligament Dense elastic fibers Vertebra

Elastic fibers Collagen fibrils

Cartilage

Hyaline Cartilage: Type II Collagen Matrix Chondrocytes

Hyaline Cartilage

Elastic Cartilage: Elastic Fibers Type II Collagen (pinna of ear)

Fibrocartilage Type I collagen

Adipose Tissue

White Fat

Brown Fat

Brown Adipose Tissue Lipid droplet Mitochondria

Basement Membranes

Basement Membrane: Silver Stain (kidney tubules)

Basement Membrane: Kidney Tubules (PAS stain for glycoproteins)

Epithelial cell Basement membrane Fibroblast

Cells of the Immune/Inflammatory System in the Extracellular Matrix

Intestinal Villus; XS Plasma Cells PMN

Plasma Cell

Loose Connective Tissue: Tongue with Mast Cells

Mesentery with Mast Cells

Mast Cell EM: Resting

Mast Cell: Itching

Macrophage

Some pathology to think about.

Chondrosarcoma

Ehlers-Danlos Syndrome What connective tissue molecular defects might result in this picture?

Ehlers-Danlos Syndrome What connective tissue molecular defects might result in this picture?

Lipoma in Small Intestine Submucosa

Submucosal Lipoma