Requirements for Presentation Length = 10 minutes/person Must have at least 5 sources – limit of 3 online sources (not Wikipedia) Background on the condition; ie: Is the cause of the condition genetic or environmental, etiology of condition, population distribution, pathology, lifestyle impacts, etc. Are there other forms of treatment other than diet alone; ie: surgery or pharmaceutical intervention? 3 day diet plan to meet the specific needs of a patient with the condition you are studying 3 questions that are able to be answered in 1-3 sentences

Scurvy: Not just for Pirates Will Brown 1/31/2012

What is scurvy? Scurvy Caused by Vitamin C Deficiency – Completely dietary, no genetic Vitamin C is required for mature collagen formation Without vitamin C the collagen precursor molecules are unstable and breakdown or disassemble Pathology of scurvy Early symptoms: malaise, lethargy, and myalgia can occur Progresses to loosening of teeth, reopening of scars, epidermal rashes and “corkscrew” hairs Late stage scurvy results in neuropathy, jaundice and eventually death.

Background Was not seen until long voyages on ships began to limit diets of fresh fruits and vegetables Epidemiology – usually restricted to poverty stricken countries with little access to fresh fruits and vegetables Also affects elderly patients who are unable to provide for themselves Can also affect people with restricted diets or those with gastrointestinal disorders such as ulcerative colitis or celiac

Background Does not show male or female preference nor does it show age preferences Minimum daily intake of vitamin c is 10 mg RDI for vitamin C = 90-100mg There is no surgical intervention Collagen is required for wound healing so surgery is not advisable Therapeutic intervention is high dose vitamin C

Breakfast Meal Plan Day 1 Vit C Day 2 Day 3 Yogurt with fresh strawberries 2/84.7 Cantelope 67 Kiwi 164 Whole wheat toast Granola Cereal w/ 1% milk 0.7/0 Scrambled eggs Glass of orange juice 124 Total: 210.7 197.7 288 Vitamin C reported in mg

Lunch Menu Day 1 Vit C Day 2 Day 3 Spinach Salad w/mandarin oranges and pecans 103.2 . Whole wheat turkey Sandwich w/watercress 43 Tomato Soup 14 Vinaigrette dressing Strawberries 84.7 Papaya 234.8 Glass of V8 juice 108 Papaya/ orange smoothie 304.5 Cantelope strawberry smoothie 151.7 Total: 211.2 432.2 400.5

Dinner Menu Day 1 Vit C Day 2 Day 3 BLT w/ spinach and whole wheat bread 28 Chili w/ beans and turkey 21.4 Fish tacos w/ cabbage 19 Fruit salad w/ papaya 300 Spinach and watercress side salad 71 Fresh Salsa 20.7 Glass of 1% milk Orange juice 124 Total: 328 216.4 339.7 Daily Totals 749 846 1028

Questions What is the cause of Scurvy? Vitamin C deficiency Vitamin C is required for the formation of ________. Keratin Bone Collagen What is the RDI for Vitamin C? 90-100 mg/day

Resources http://www.nlm.nih.gov/medlineplus/ency/article/000355.htm Adult Scurvey; Hirschmann and Raugi; J AM ACAD DERMATOL DECEMBER 1999 Food Composition Table; McGraw-Hill 2009 http://www.v8juice.com/Products.aspx www.nutrtion.gov