EpitheliumEpithelium Michael Hall PhD University of California Los Angeles University of California Los Angeles.

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Presentation transcript:

EpitheliumEpithelium Michael Hall PhD University of California Los Angeles University of California Los Angeles

Features common to all epithelia 1.The cells are closely packed together 2.The cells are polarized 3.The apex always faces an open space 4.The base always sits on a basement membrane

Epithelial cells are closely packed

Free Surface Lamina propria Epithelial cells always have a free surface and sit on a basement membrane

Epithelium Basementmembrane Epithelium Basementmembrane Note that both of the epithelia face a free surface

Types of Epithelium Simple One cell layer Stratified More than one cell layer

Types of Epithelium 1.Simple squamous 2.Simple cuboidal 3.Simple columnar 4.Stratified squamous 5.Stratified cuboidal 6.Stratified columnar 7.Pseudostratified 8.Transitional

Simple squamous epithelium Basement membrane Connective tissue Free space

Simple squamous epithelium (endothelium) lining an arteriole endothelium

Simple cuboidal epithelium (kidney) Free surface Basement membranes

ss q sc u sc u* Simple epithelia in kidney medulla

Simple columnar epithelium (duodenum)

Stratified Squamous Epithelium (cornea) bm ct free surface

Stratified Squamous Epithelium free surface basement membrane squamous cells

Stratified Cuboidal Epithelium Duct of sweat gland Basement membrane Connective tissue

Stratified Columnar Epithelium (urethra) lp bm Columnar cells

PseudostratifiedEpithelium

Basement Membrane Pseudostratified Columnar Epithelium (duodenum) Basal cells

Transitional Epithelium (Urinary system)

TransitionalEpithelium (relaxed -top layer of cells is cuboidal) TransitionalEpithelium (stretched-top layer of cells is squamous) basement membrane

Mesothelium endothelium Endothelium Mesothelium is the name given to the simple squamous epithelium that lines the closed cavities of the body

Basement membranes

Simple squamous epithelium Basement membrane Connective tissue

Basement Membrane of epithelium

Molecular structure of extracellular matrix forming the basement membrane forming the basement membrane Inside of cell

Junctional Complexes

‘Terminal Bars’ between epithelial cells

Epithelial Junctional Complex Z. occludens Z. adherens Desmosome Cell 1 Cell 2

Components of the Epithelial Junctional Complex 1.Z. occludens 2.Z. adherens 3.Macula adherens (desmosome) 4. Gap junction 5. Hemidesmosome

Generalized Structure of a Junctional Complex Cell 1 Cell 2

< 1,500 Da > 1,500 Da Connexon 2 Connexon 1 Gap Junction

Surface Specializations of Epithelial Cells

Myosin Actin Spectrin Structure of a microvillus Fimbrin Villin

Stereocilia in the Epididymis Stereocilia

Cilia in the Respiratory Mucosa Cilia

cilia microvilli

Basement membrane Mucosa Components of a Mucosa

The End Whoopee !!