Male genital pathology Pathology pictures

62 year old male SCC of the penis, spreading through the vessels of the corpora cavernosa

Malignant penile carcinoma

59 year old male with haemochromatosis and cirrhosis Testicular atrophy

Atrophic testis Low power: tunica albuginea (long arrow); seminiferous tubules (short arrow) High power: Leydig cells (long arrow); atrophic tubules (short arrows); thickened basement membrane; lack of spermatogenesis Low power High power

A: normal testis B: testicular atrophy  tubules have Sertoli cells but no spermatogenesis; thickened basement membrane; apparent increase in interstitial Leydig cells

30 year old man with dystrophia myotonica Advanced testicular atrophy

Epididymitis and orchitis

71 year old male with prostatic hyperplasia Chronic granulomatous epididymo-orchitis Blue arrows: cream nodules comprising lipid-laden macrophages Black arrows: hydrocoele

Tuberculous epididymo-orchitis Predominantly affecting the epididymis (arrows)

Tertiary syphilis Gumma (arrows) of the testis Multiple irregular areas of necrosis surrounded by a zone of dense fibrosis No recognisable testicular tissue remains

Haemorrhagic infarction of testis due to torsion of spermatic cord

Testis which has recently undergone infarction Low power: tunica albuginea (long arrow); infarcted tubule (small arrow) High power: necrotic seminiferous tubules (long arrows); oedema separating tubules (short arrows)

Haemorrhagic necrosis of the testis and epididymis due to torsion of the spermatic cord

Testicular torsion

Torsion of the testicular appendix

Bilateral cysts of epididymis

40 year old male Seminoma of the testis Homogeneous cream colour Testicular tumours are usually a mixture of seminoma and teratoma components

Seminoma of the testis Fairly well circumscribed, pale, fleshy, homogeneous mass

Embryonal carcinoma Haemorrhagic mass

Choriocarcinoma Small size; marked haemorrhage and necrosis

17 year old male Malignant teratoma of the testis Varied macroscopic appearance from one area to another

High power view of seminoma component: tumour cells (arrows) have large central nuclei and clear cytoplasm; fibrous connective tissue septae infiltrated with chronic inflammatory cells (arrowheads) Immature testicular teratoma Low power: tunica (A); residual seminiferous tubules (B); varied picture within and between fields High power: immature mesenchyme (A); immature cartilage (B); seminoma (C)  seminoma can form a component of a mixed germ cell tumour

Man aged 35 with ‘cannon ball’ secondaries in the lungs and a positive pregnancy test Immature teratoma of the testis with a choriocarcinoma component Haemorrhagic necrosis of choriocarcinoma component (characteristic  due to tumour cells invading blood vessels) Homogenous white areas: seminoma

Teratoma of the testis Variegated cut surface with cysts

Mature teratoma

Immature teratoma

72 year old male Hydrocoele (blue arrows) with atrophic testis (red arrows)

6 year old male Hydrocoele of the spermatic cord

Chronic haematocoele (blue arrows) with testicular atrophy (red arrows)

Man aged 58 Varicocoele (blue arrows) Appendix of epididymis (red arrows) Hydatid of Morgagni (black arrow) with twisted pedicle

72 year old male with DM complicating haemochromatosis Prostatic abscess Blue arrows: pyogenic membrane (abscess contents removed)

83 year old male Nodular hyperplasia of the prostate and muscle hypertrophy and trabeculation of the bladder

Low power High power Low power: increased stroma and proliferated glands (arrows) High power: double layer of nuclei (long arrows); regular nuclei and inconspicuous nucleoli (arrowheads) Medium power

Prostatic hyperplasia Hypertrophy of bladder muscle Cystitis Bilateral hydroureter and hydronephrosis Suppurative pyelonephritis

BPH Well-define nodules compress the urethra into a slit-like lumen Histology: nodules of hyperplastic glands on both sides of the urethra

Carcinoma in the posterior prostate

Adenocarcinoma of the prostate Low power: proliferation of closely-packed small glands; infiltrating into surrounding stroma High power: glands are closely applied (long arrows); enlarged, hyperchromatic nuclei; nuclei are irregularly arranged in the cells (arrowheads) Low power High power

Poorly differentiated prostatic adenocarcinoma Almost complete loss of the glandular architecture, pleomorphic nulei, prominent nucleoli

Advanced carcinoma of the prostate

Adenocarcinoma of the prostate Lower left is posterior aspect (where carcinomatous tissue is) Solid white tissue of cancer  unlike spongy appearance of benign peripheral zone