Production of Urine David Taylor

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Presentation transcript:

Production of Urine David Taylor

 When you have worked through this you should be able to explain  Auto regulation of renal blood flow  Formation of urine and its composition  Filtration, tubular reabsorption and secretion  Filtration membrane  Glomerular filtration rate (GFR) – what is this and its regulation Production of Urine

 These slides are available with all my other lectures on my website  In the text books: Chapters 25,26, 27 and 28 in Preston and Wilson (2013) Chapter 14 in Naish and Court (2014) Resources

Auto regulation of renal blood flow  Kidney blood flow remains constant over a range of mean arterial blood pressure between 80 and about 180mmHg  This is autoregulation, and we have covered it before! pp in Preston and Wilson (2013) pp in Naish and Court (2014)

Formation of urine and its composition

Filtration Fig in Preston and Wilson (2013) p. 665 in Naish and Court (2014)

 There are many (copyrighted) pictures of the basement membrane in the glomerulus.  The capillary endothelial cells are surrounded by a basement membrane, which is supported by podocytes.  The podocytes interdigitate, leaving filtration spaces between them through which the filtrate passes under pressure. Filtration membrane p.317 in Preston and Wilson (2013) p. 661 in Naish and Court (2014)

Glomerular filtration rate (GFR) p.319 and in Preston and Wilson (2013) pp and Fig in Naish and Court (2014)