A fluid–structure interaction model to characterize bone cell stimulation in parallel-plate flow chamber systems by T. J. Vaughan, M. G. Haugh, and L. M. McNamara Interface Volume 10(81): April 6, 2013 ©2013 by The Royal Society

(a) Parallel plate flow chamber system under investigation: (i) syringe-driven pump; (ii) inlet tubing; (iii) inlet reservoir; (iv) channel region; (v) outlet reservoir; (vi) outlet tubing; (vii) atmospheric outlet and (b) Cox-2 expression in MLO-Y4 mouse o... T. J. Vaughan et al. J. R. Soc. Interface 2013;10: ©2013 by The Royal Society

(a) Global CFD model of the PPFC system and (b) local FSI model that considers fluid–solid interactions between fluid media and osteoblast cell. T. J. Vaughan et al. J. R. Soc. Interface 2013;10: ©2013 by The Royal Society

Flow characteristics of the global CFD model: (a) WSS profile (b) pressure profile along the X- direction and (c) velocity profile in the Y-direction. T. J. Vaughan et al. J. R. Soc. Interface 2013;10: ©2013 by The Royal Society

Effect of volumetric flow rate in the local FSI model: (a) WSS profile and (b) pressure profile along the X-direction. T. J. Vaughan et al. J. R. Soc. Interface 2013;10: ©2013 by The Royal Society

Effect of outlet pressure in the local FSI model: (a) WSS profile and (b) pressure profile along the X-direction. T. J. Vaughan et al. J. R. Soc. Interface 2013;10: ©2013 by The Royal Society

Effect of WSS in the local FSI model: (a) WSS profile and (b) pressure profile along the X- direction. T. J. Vaughan et al. J. R. Soc. Interface 2013;10: ©2013 by The Royal Society

Isolated pressure and WSS cases in the local FSI model: (a) WSS profile and (b) pressure profile along the X-direction. T. J. Vaughan et al. J. R. Soc. Interface 2013;10: ©2013 by The Royal Society