Thank you for viewing this presentation. We would like to remind you that this material is the property of the author. It is provided to you by the ERS.

Slides:

Advertisements

Similar presentations

HIV TB. World wide TB is the most common cause of death in people with HIV About 1/3 of HIV infected people worldwide are co-infected with TB (co-infection.

Advertisements

Utility of IGRAs in children when used as per Canadian Guidelines Winsley Rose Wanatpreeya Phongsamart Kerry Chong Ray Lam Ian Kitai No conflicts of interest.

A typical day in the TB clinic You see the following patients in the TB clinic. All have normal CXRs: 1. A 35 year old man from Hartford with a 16 mm positive.

QuantiFERON®-TB Gold Test

ARE CAP AND HCAP TWO SEPARATE ENTITIES? Francesco Blasi Department Pathophysiology and Transplantation, University of Milan, Italy.

Anti-TNF, Immunosuppression and Renal Disease: Approaches in TB Dr Heather Milburn Consultant Respiratory Physician Guy’s & St Thomas’ NHS Foundation Trust.

Continuity Clinic Tuberculosis. Continuity Clinic Objectives Know current epidemiologic trends in TB Know indications for testing for TB exposure and.

1 Tuberculosis: The Epidemiology, Diagnosis and Prevention Assisted Living Residence Advisory Committee Meeting Mary Goggin, RN, MPH April 28,2011.

TB chemoprophylaxis Graham Bothamley Clinical Director, NE London TB Network.

Latent Infection of Tuberculosis in China HUASHAN HOSPITAL, FUDAN UNIVERSITY, Shanghai, China Wenhong Zhang, M.D & PhD.

Screening of Latent Tuberculosis before treatment with TNF  blockers Ori Elkayam M.D Tel Aviv Medical Center.

Prevention Bacille Calmette Guerin (BCG) Vaccine Live attenuated strain of Mycobacterium bovis; 1921 Efficacy Clinical trials UK: protective effect of.

Dr R.Reesaul Chest Physician Chest Clinic P. D`or Hospital

Thank you for viewing this presentation. We would like to remind you that this material is the property of the author. It is provided to you by the ERS.

Thank you for viewing this presentation.

Thank you for viewing this presentation. We would like to remind you that this material is the property of the author. It is provided to you by the ERS.

S AFETY OF I SONIAZID P REVENTIVE T HERAPY A MONG HIV- INFECTED P REGNANT W OMEN IN H IGH TB I NCIDENCE S ETTINGS : STUDY UPDATE OF IMPAACT P1078 (APPRISE)

“Diagnosis and treatment of latent TB ” Update – Internal Medicine

New Tools for Diagnosing Latent TB

Elizabeth A. Talbot MD Associate Professor, Deputy State Epi Infectious Disease & International Health Geisel School of Medicine at Dartmouth Latent TB.

Jean-Pierre Zellweger Swiss Lung Association Berne, Switzerland

Update on Interferon Gamma Release Assays for the Laboratory Detection of Mycobacterium tuberculosis Infection David Warshauer, Ph.D., D(ABMM) Deputy Director.

October 3, Serial Testing of Health Care Workers for Tuberculosis Using Interferon-γ Assay Madhukar Pai, et. al. American Journal of Respiratory.

TB or not TB ? Mahmoud Abu-Shakra Rheumatic disease Unit

Christoph Lange & Giovanni Sotgiu Principles of designing a TB and MDR-TB drug regimen.

Allen Kraut, MD, FRCPC Medical Director, Occupational Health WRHA

New Entrant TB Screening Dr. John P. Watson Consultant Respiratory Physician.

1 Tuberculosis: Basics Rick Speare Anton Breinl Centre School of Public Health, Tropical Medicine and Rehabilitation Sciences James Cook University 16.

Update on Tuberculosis contact investigation

Isoniazid preventive therapy for people living with HIV: Public health challenges and implementation issues Peter Godfrey-Faussett UNAIDS (with thanks.

بسم الله الرحمن الرحيم. A 25 year old Saudi male applied to work as paramedic. He has no symptoms or history of contact with sick patients. His physical.

Epidemiology of Tuberculosis Prof. Ashry Gad Mohamed MBChB, MPH, DrPH.

HIV/TB – Case Studies David Schlossberg, MD, FACP Medical Director, TB Control Program Philadelphia Department of Health.

IGRAs: Should they replace the TST in the identification of latent tuberculosis? Objectives Describe how interferon-gamma release assays (IGRAs) work.

Tuberculosis in North Dakota 2011 Craig Steffens, MPH TB/HIV Surveillance Coordinator.

TUBERCULOSIS Pyrexia, fatigue, night sweats, weight

Thank you for viewing this presentation. We would like to remind you that this material is the property of the author. It is provided to you by the ERS.

Maria N. Gamaletsou 1,2, David Denning 1, and Nikolaos V. Sipsas 2 1 The National Aspergillosis Centre, University Hospital of South Manchester and The.

Tuberculosis August 17, 2010 Tuberculosis Mycobacterium tuberculosis – Fastidious, aerobic, acid-fast bacillus Tremendous increase in incidence over.

Contact Investigation Dr. Essam Elmoghazy. Contact Investigations – A Crucial Prevention Strategy On average, 10 contacts are identified for each person.

GERIATRIC TUBERCULOSIS: ISSUES Dr. (Prof.)Vijay Kumar Arora Vice Chancellor Ex Director NITRD Delhi,Ex Director-professor JIPMER, Ex Additional DGHS GOI.

More information © 2015 Denver Public Health Michelle K Haas, Kaylynn Aiona, Pete Dupree, Ellen Brilliant, Robert Belknap Improving access to Tuberculosis.

Tuberculosis in Children and Young Adults

Diagnosis of pulmonary tuberculosis

IFN-γ Release Assays in the Diagnosis of Latent Tuberculosis Infection among Immunocompromised Adults Gil Redelman-Sidi and Kent A. Sepkowitz Am J Respir.

Depart. of Pulmonology R4 백승숙. 1. INTRODUCTION 2. BACKGROUND 3. DIAGNOSIS OF LATENT TB INFECTION 4. CHEMOPROPHYLAXIS 5. RISKS OF TUBERCULOSIS AND OF DRUG-INDUCED.

TB PREVENTION by Assoc. Prof. Dr. Nik Sherina Haidi Hanafi 1.

Depart. of Pulmonology 백승숙. More than 80% of cases of tuberculosis in the United States –The result of reactivated latent infection –Nearly all these.

TB: The Elispot In The Room Dr Jessica Potter TB Research Registrar Barts Health NHS Trust.

Institute for Health Service Research for Healthcare Workers (CVcare)

Tuberculosis Screening and Case Finding Among Migrants

Figure 1. Paradigm for evaluation of those with latent tuberculosis infection (LTBI) based on risk of infection, risk of progression to tuberculosis, and.

QuantiFERON® Blood Test for the Detection of

Volume 142, Issue 1, Pages (July 2012)

The intersection between diabetes and tuberculosis: a perspective

Latent Tuberculosis Infection: An Update on Diagnosis

Cryptococcosis: Epidemiology of cryptococcal disease

Cryptococcosis: Epidemiology of cryptococcal disease

PPD status of CZP-treated patients with RA in the pooled RA safety database (N=4049) at baseline and TB incidence by INH treatment. †One patient who developed.

Latent TB Infection among Diabetic patients

Cumulative incidence of tuberculosis (TB) in certolizumab pegol (CZP)-treated patients with rheumatoid arthritis (RA) in the pooled RA safety database.

Entry, Randomization, and Follow-up of Patients in the Hypertension in the Very Elderly Trial Of the 461 patients who did not meet the protocol criteria,

3-year survival of lung cancer patients in the general population and in those with a prior diagnosis of chronic obstructive pulmonary disease (COPD).

Immune reconstitution inflammatory syndrome (IRIS) associated with Mycobacterium tuberculosis (TB) infection. a) In healthy individuals in response to.

Latent TB Infection (LTBI)

Treatment algorithm for chronic thromboembolic pulmonary hypertension.

A) Chest computed tomography image showing left upper lobe cavitary lesion consistent with invasive pulmonary aspergillosis (IPA) in an allogeneic haematopoietic.

Presentation transcript:

Thank you for viewing this presentation. We would like to remind you that this material is the property of the author. It is provided to you by the ERS for your personal use only, as submitted by the author.  2012 by the author

Christoph Lange IGRAs for the diagnosis of tuberculosis:... is the party over?

Incidence of tuberculosis in Germany Robert-Koch-Institute 2011

Robert-Koch-Institute 2020? Incidence of tuberculosis in Germany

Global incidence of tuberculosis WHO 2010

8. position of leading causes of deaths 1/3 of the world´s population could be infected > 80% can be cured prevention can be > 90% effective Tuberculosis WHO 2011

Lin P et al. J Immunol 2010 Clearance Pulmonary TB Low grade TB “percolating“ Dormant infection Septic TB Miliary TB Extrapulmonary TB LTBI active TB Spectrum of M. tuberculosis infection

x Prevention Diagnosis Treatment

v Pirquet C; Wien Med Wschr 1907 An allergy-test for the diagnosis of tuberculosis

v Pirquet C; Wien Med Wschr 1907 An allergy-test for the diagnosis of tuberculosis

TB cowboys

Proteom of M. tuberculosis und M. bovis BCG Jungblut PR et al.; Mol Microbiol 1999 M. tuberculosisM. bovis BCG

LTBI is defined by a positive reaction in the TST or IGRA

The risk for tuberculosis Horseburgh et al. NEJM 2011

The risk of tuberculosis in TST +ve individuals Comstock GW et al.; Am J Epidemiol 1974

Diel R et al.; AJRCCM 2011 Contact tracing

Aichelburg MC et al.Clin Infect Dis 2009 HIV-seropositives

Kim SH et al. Am J Transplant 2011 Transplantation

Leung CC et al. AJRCCM 2010 Silicosis

Diel R et al. Eur Respir J 2011 NPV of the TST and IGRAs for the development of tuberculosis TestNPV TST99.7 QFT-G-IT99.8 T-Spot.TB97.8

Diel R et al. Eur Respir J 2011 PPV and NPV of the TST and IGRAs for the development of tuberculosis TestPPVNPV TST QFT-G-IT T-Spot.TB

Unadjusted cumulative incidence risk ratios for positive vs negative IGRA test results including studies with possible bias Rangaka M et al. Lancet 2011

Unadjusted incidence rates by test result Rangaka M et al. Lancet 2011

„Intention to test is intention to treat“

IsoniazidRifampicin Prevention of tuberculosis

Sterling T et al. NEJM 2011

FZB Retreat Nov

What is the predictive value of IGRAs for the diagnosis of tuberculosis? n = european centers Update May 2012: n= 4500

APC T cell cytokine induction cytokine induction cytokine induction ELISAELISPOT assaySkin test IGRA IFN-  release assay PPD ESAT-6/CFP-10/TB7.7 Negative controls Positive control IGRAs and skin-testing in immunocompromised patients: a multicenter study

What is the predictive value of IGRAs for the diagnosis of TB in immunosuppressed individuals? Patientgrouptotal chronic renal failure275 control225 HIV infected patient786 rheumatoid arthritis206 solid organ transplant recipient197 stem cell transplant recipient103 total european centers