- D A N I S H A G I N G R E S E A R C H C E N T E R - www.sdu.dk/darc Why do we age so differently? VELUX FONDEN Funded by: Social Inequality in Health.

Slides:

Advertisements

Similar presentations

ESRC Gender Equality Network GeNet Project 2: Biographical Agency and Developmental Outcomes Ingrid Schoon, Andy Ross, Peter Martin, and Steven Hope City.

Advertisements

How would you explain the smoking paradox. Smokers fair better after an infarction in hospital than non-smokers. This apparently disagrees with the view.

The importance of life course research in an aging population ESRC International Centre for Life Course Studies in Society and Health UC London, Imperial,

The Postponement of Childbearing, Completed Fertility and Subjective Well-being Hans-Peter Kohler Axel Skytthe and Kaare Christensen University of Pennsylvania.

Plan for the coming years VELUX FONDEN - D A N I S H A G I N G R E S E A R C H C E N T E R - Why do we age so differently?

The Copenhagen Group 1st year evaluation meeting 18 – 19 May 2009 Hotel Marienlyst, Helsingor D anish A ging R esearch C enter VELUX FONDEN - D A N I S.

Congenital malformations and birth weight: a family perspective Dr. Kari K.Melve Department of Public Health & Primary Health Care University of Bergen,

Meet the Author Webcast Public Health Reports Meet the Author Webcast Socioeconomic Status and Risk of Diabetes-Related Morality in the United States With.

Ethnic and socioeconomic trends in testicular cancer incidence in New Zealand Diana Sarfati, Caroline Shaw, June Atkinson, James Stanley, Tony Blakely.

Background: Self-rated health (SRH) is widely used in research on health inequalities by socioeconomic status. However, researchers must be certain that.

Revisiting causal neighborhood effects on individual ischemic heart disease risk: a quasi-experimental analysis among Swedish siblings Juan Merlo In collaboration.

School of Social and Community Medicine University of BRISTOL Environmental and genetic influences on childhood growth trajectories Laura D Howe.

Socioeconomic factors in relation to Autism Spectrum Disorders Dheeraj Rai and Selma Idring 17 March 2014

The Relationship Between Weight Status During Early Adulthood And Successful Aging In Elderly Canadian Males: The Manitoba Follow-up Study Dennis J. Bayomi,

 What Problems Cause Distress and Impair Functioning?  What Problems Cause Distress and Impair Functioning?  Why do People Behave in Unusual Ways?

April 6, o What is cancer? o Cancer statistics o Cancer prevention and early detection o Cancer disparities o Cancer survivorship o Cancer research.

Purposes and uses of cancer registration E.E.U. Akang Department of Pathology University College Hospital Ibadan, Nigeria.

Social Aspects of Diseases. Dr. Mostafa Arafa Associate Prof. of Family and Community medicine Faculty of medicine, medical sciences King Khaled University,

- D A N I S H A G I N G R E S E A R C H C E N T E R - Socioeconomic position (SEP) and ageing Why do we age so differently? Merete Osler.

Plan for the coming years VELUX FONDEN - D A N I S H A G I N G R E S E A R C H C E N T E R - Why do we age so differently?

Biology in Focus, HSC Course Glenda Childrawi, Margaret Robson and Stephanie Hollis A Search For Better Health Topic 11: Epidemiology.

Descriptive Epidemiology

Presented by: Caitlin Cleary. Depression Depression is among the top five leading causes of disability and disease burden throughout the world Stressful.

ScandinaviaOdense, home town of Hans Christian Andersen.

報告者王瓊琦. postpartum depression : identification of women at risk.

Prescription registers in Denmark Morten Andersen Senior Researcher, PhD Clinical Pharmacologist Nordic Congress of General Practice Copenhagen, May 2009.

Description of fracture with endocrine therapy use in older breast cancer survivors in a population-based setting Taryn Becker 123, Geoff Anderson 123,

International Standard Classification of Education (ISCED) IGCSE Global Perspectives.

© 2010 Pearson Prentice Hall. All rights reserved Chapter Data Collection 1.

Diabetes incidence and long-term exposure to air pollution: a cohort study Zorana Jovanovic Andersen ISEE.

Multiple Choice Questions for discussion

Successful Ageing Influence of socio-economic factors, gender and health service provision Shah Ebrahim London School of Hygiene & Tropical Medicine CADENZA.

The Relationship of Surgeon and Hospital Volume with Long-Term Survival For Women with Breast Cancer Patrick J. Roohan New York State Department of Health.

1 Testing and developing statistical models for adoption studies of genetic and environmental influences of premature death Introduction and summary Paper.

‘STROKE’ February 2011 Dr Amer Jafar ABHB/Gwent. Decreased Kidney Function  Chronic kidney disease is an important risk factor for development and progression.

Old, Sick and Alone ? Living arrangements, health and well- being among older people RGS-IBG Annual International Conference London, 2006 Harriet Young.

1 Representations of the Childhood Overweight Problem in Los Angeles County June 24, 2007 County of Los Angeles Public Health Department Nutrition Program.

Goldstein (1988) Gottesman & Shields (1966)

Parents’ basic skills and children’s test scores Augustin De Coulon, Elena Meschi and Anna Vignoles.

Long-term exposure to air pollution and asthma hospitalisations in older adults: a cohort study Zorana Jovanovic Andersen ERS Conflict of interest.

Impact of Socioeconomic Status on Cardiovascular Disease and Mortality in 24,947 Individuals With Type 1 Diabetes Featured Article: Araz Rawshani, Ann-Marie.

Causes of schizophrenia

Socio-economic inequalities in the pathway of care for pancreatic cancer James Brown, Jean Adams, Martin White & Mark Pearce Institute of Health & Society.

1 ‘Intergenerational Mobility in UK, life chances and the Role of Inequality and Education Paul Gregg Presentation to IFS Poverty Review Workshop 7 th.

MARC Project 4: Australian Children of Alcoholic Female Twins Wendy S. Slutske, Valerie S. Knopik, Theodore Jacob, Michael T. Lynskey, & Anne Glowinski.

HARMONY Study of Dementia in Swedish Twins health Hälsa genes ARv environment Miljö and Och newNY NIA grant R01AG08724 and the Alzheimer’s Association.

A short introduction to epidemiology Chapter 4: More complex study designs Neil Pearce Centre for Public Health Research Massey University Wellington,

Chapter 2 Nature of the evidence. Chapter overview Introduction What is epidemiology? Measuring physical activity and fitness in population studies Laboratory-based.

Do Instrumental Activities of Daily Living Predict Dementia at 1- and 2- Year Follow-Up? Findings from the Development of Screening Guidelines and Diagnostic.

MRC/CSO Social and Public Health Sciences Unit Socioeconomic gradients in coronary heart disease - the relative role of lifestyle Linsay Gray 1, Julie.

1 Lecture 6: Descriptive follow-up studies Natural history of disease and prognosis Survival analysis: Kaplan-Meier survival curves Cox proportional hazards.

Predicting Stage Transitions in the Development of Nicotine Dependence Carolyn E. Sartor, Hong Xian, Jeffrey F. Scherrer, Michael Lynskey, William True,

Danish National Birth Cohort (DNBC) I4C_Lyon 2009 Methods and Data collection Population sample Years of recruitment: Sampling method:

Workshop II Health inequalities among children and adolescents Matthias Richter University of Bielefeld School of Public Health Department of Prevention.

SIMONE CROFT USING PUBLICLY AVAILABLE COHORT STUDIES.

Obesity, Nutrition and Nutri-genonmics

Incidence and prognosis of hepatocellular adenoma in Denmark Lars Bossen Departments of Hepatology and Gastroenterology and Clinical Epidemiology Aarhus.

Performance assessment A performance assessment framework is a collation of statistics across a district or within a hospital and is far removed from.

Use of lung function tests in paediatric asthma care A nationwide registry study Grete Moth, MHSc, Ph.D Danish Paediatric Asthma Centre Aarhus University.

Distribution of health and Illness Social Class. Aims & Objectives Analyse data that demonstrates health inequality (class, gender, ethnicity) Analyse.

BREAST CANCER BY STAGE OF DISEASE AT DIAGNOSIS, CENTRAL OKLAHOMA Arthur Owora, MPH; Aaron Wendelboe, PhD; David Thompson, PhD; Janis Campbell, PhD The.

1 Overview of presentation 1.Context 2.Objectives 3.Methods 4.What has been achieved 5.What has to be done NCSI-CYP – Risk Stratification Investigation.

A guide to the statistics used in the ScotPHO profiles.

Depressed mood and cause-specific mortality: a 40-year general community assessment 박세진.

Parent-Child Interactions in Children with Advanced and Non-Advanced Cancer: Children’s Perspectives during the First Year Post-Diagnosis 1 The Research.

Association between GDP and old-age mortality in seven European countries, A life-course perspective F.Janssen, A.E.Kunst, J.P.Mackenbach Department.

Rhematoid Rthritis Respiratory disorders

Investigation Response Team: Descriptive Health Data

Mendelian Randomization (Using genes to tell us about the environment)

Dr Luis E Cuevas – LSTM Julia Critchley

Presentation transcript:

- D A N I S H A G I N G R E S E A R C H C E N T E R - Why do we age so differently? VELUX FONDEN Funded by: Social Inequality in Health – Causation and Selection: A Twin Approach Ph.D. Student Mia Madsen DARC: Odense & Copenhagen, Project start June 2008 Supervisors Kaare Christensen, Merete Osler, Anne-Marie Nybo Andersen

- D A N I S H A G I N G R E S E A R C H C E N T E R - Research question  A strong and consistent association between socioeconomic position and health is well-established, but is this association a true causal relationship or a spurious one, produced by underlying background factors?

- D A N I S H A G I N G R E S E A R C H C E N T E R - Matched on genotype (partly or fully) and childhood environment Do they differ significantly with respect to health outcomes? Discordant on adult SEP Analytical approach Causation or selection?

- D A N I S H A G I N G R E S E A R C H C E N T E R - The principal of twin studies: Three comparisons CohortDZMZ Early environmental confounding ↑↑-- Genetic confounding↑↑↑- No confounding by genes or common environment ↑↑

- D A N I S H A G I N G R E S E A R C H C E N T E R - The evidence so far…  Contradictory findings  Generally, no association between SEP and health when genetic constitution and rearing environment are controlled for. Osler et al. 2007, Osler et al & Behrman et al. (work in progress) (Danish data)  Persisting association between SEP and health in intra-pair analyses (Krieger et al & Lundborg 2008) (American data)

- D A N I S H A G I N G R E S E A R C H C E N T E R - Social Science and Medicine, 2009

- D A N I S H A G I N G R E S E A R C H C E N T E R - Evidence continued…  Societal context seems to play a role  Results seem to depend on the social indicators used  Results seem to vary according to health outcomes studied  Power limitations?  Chance findings?

- D A N I S H A G I N G R E S E A R C H C E N T E R - Editorial IJE  ”...These are important findings that now require replication in larger twin data sets using a wider range of health outcomes…” (Ebrahim, S)  Aim: In nation-wide registers to investigate the effect of different social indicators during the life course on survival and a wide range of different health outcomes in a twin population matched on early life experiences and genetic make-up (partly or fully)

- D A N I S H A G I N G R E S E A R C H C E N T E R - Data sources & information  Danish Twin Registry (1870 and onwards, N=75,000+)  Statistics Denmark (Information on all twins + 5% sample of all birth cohorts from the general population)  Health  Causes of death ( )  Hospitalizations (incl. diagnoses, operations, and accidents causing admission to hospital ( ))  Cancer registry (soon)  Social data  Income ( )  Occupation ( )  Socio-economic position ( )  Civil status ( )  Education ( )

- D A N I S H A G I N G R E S E A R C H C E N T E R - 1st paper – initial analyses  Educational status and all cause and cause- specific mortality  Follow-up:  Education: 1980, International Standard of Classification (ISCED) (Primary/Secondary, Upper secondary/Post- secondary non-tertiary, Tertiary)  Mortality: All cause, CVD (+ischemic and stroke), Cancer, Smoking-related cancer, Respiratory causes, External causes, Abnormal findings/insufficiently defined symptoms

- D A N I S H A G I N G R E S E A R C H C E N T E R - Study population

- D A N I S H A G I N G R E S E A R C H C E N T E R - Descriptives, education Educational status (ISCED)N% Primary/secondary13, Post-secondary9, Tertiary3, Missing Total cohort27,  Discordant twin pairs  Primary/secondary & Post-secondary: N=6000 (900 MZ)  Primary/secondary & Tertiary: N=3060 (402 MZ)  Post-secondary & Tertiary: N=1456 (198 MZ)

- D A N I S H A G I N G R E S E A R C H C E N T E R - Educational status and selected causes of death Cox regression analysis

- D A N I S H A G I N G R E S E A R C H C E N T E R - Summary of results  The effect of education seems to persist in the intrapair analyses for all cause mortality and CVD. For cancer the pattern is less clear.  Results are compatible with an independent effect of educational status in adulthood above and beyond genetic constitution and other background factors.