History of the Dan L. Duncan Cancer Center 1997Strategic plan recommendation 2002Successful P20 application Programs, shared resources, organizational structure, infrastructure 2006P30 CCSG submitted Duncan gift 2007NCI Cancer Center grant awarded

Mission of the Dan L. Duncan Cancer Center To provide exceptional patient care To provide outstanding education for students To conduct innovative research into the causes, prevention and treatment of cancer To provide community outreach and education, especially to the underserved To prevent and ultimately cure cancer in all of its forms

Hospital Partnerships and Patient Care Programs Harris County Hospital District

BCM Affiliates & Facilities BCM Clinic Rice Consortium Texas Children’s Hospital St. Luke’s Hospital Alkek Research Tower Baylor College of Medicine Ben Taub General Hospital Michael E. DeBakey VA Medical Center

Parkwood RICE UNIVERSITY VAMC The Texas Medical Center

Research Programs Cancer BiologyFranko DeMayo, PhD Molecular CarcinogenesisJanet Butel, PhD Nuclear ReceptorsOrla Conneely, PhD Breast CancerDan Medina, PhD Cell and Gene TherapyMalcolm Brenner, MD, PhD Prostate CancerTim Thompson, PhD Cancer PreventionPowel Brown, MD, PhD Pediatric CancerDavid Poplack, MD

Membership and Grant Support Total members270 NCI Grant Support ≈$ 40M Total Cancer Funding ≈$100M SPOREs3 Program Projects5 U01 Mouse Models4 U542 U192 LLS SCOR1 U01 Redes en Accion1

Developing Program Working Groups Gastrointestinal Cancer Pancreas Cancer Lymphoma Melanoma Gene sequencing of human tumors

Shared Resources Genetically Engineered Mouse Franco DeMayo, PhD Integrated MicroscopyMike Mancini, PhD Protein Expression/Proteomics Genomic Profiling ……………………… Biostatistics/Data Management Clinical Trials Support Unit Cell Processing/Vector Production Dean Edwards, PhD Lisa White, PhD and Eastwood Leung, PhD Sue Hilsenbeck, PhD Martha Mims, MD, PhD Adrian Gee, PhD Cytogenetics Core Flow Cytometry Rizwan Naeem, MD Dorothy Lewis, PhD Tissue Acquisition/ PathologyTom Wheeler, MD

Other Baylor Core Facilities Bioinformatics Research Center Blot Analysis DNA Sequencing Interdepartmental Deconvolution Microscope Vector Development Mouse Phenotyping

Clinical Research 4,000 new cancer patients diagnosed annually in partner hospitals 40% minority; 55% female 90 Investigator-initiated trials NCI-funded cooperative group membership - SWOG- COG - NSABP- PBTC - ACOSOG- CALGB

Nanoshell Treatment of U373 Glioma Cells Bare-NSAnti-IL-13r-NS Live Dead PEG-NS In press, Neuro-Oncology, 2007

Future Plans of the DLDCC in Nanotechnology & Nanomedicine Continue ongoing collaborations on nanotechnology projects with Rice and UT High priority for ongoing/future research Encourage faculty participation in the Keck Center Nanobiology Training program Encourage trainees to participate in training programs/projects in nanotechnology Commitment to space in the Rice Consortium building