TIMETABLE 1 BIOINFORMATICS_14 (Advanced Biological Chemistry) 1. Introductory remarks on biochemical information resources

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Assisted by: Andrea Bernini Ottavia Spiga Simone Gardini Powerpoint slides to be downloaded from: BIOINFORMATICS_14 (Advanced Biological Chemistry) Academic year Neri Niccolai 3 1. Introductory remarks on biochemical information resources

4 BIOINFORMATICS_14 (Advanced Biological Chemistry)

5 syllabus: 1.Introductory remarks on biochemical information resources 2.Nucleic acids and proteins in one and more dimensions 3.Retrieving information from nucleotide and amino acid sequences 4.3D structure predictions of RNAs and proteins 5.Bioinformatics for pathogen protection 6.Practicals on Immuno-Bioinformatics BIOINFORMATICS_14 1. Introductory remarks on biochemical information resources written test

6 TEXTBOOK BIOINFORMATICS_14 1. Introductory remarks on biochemical information resources

7 TEXTBOOK BIOINFORMATICS_14 1. Introductory remarks on biochemical information resources

Automatic procedures Robotics exploring Life in post-genomic era 8 1. Introductory remarks on biochemical information resources

Databank 1 Databank 2 Databank 4 Databank 5 Databank 3 Databank n Bioinformatics Bioknowledge huge amount of data distributed in databank exploring Life in post-genomic era 9 1. Introductory remarks on biochemical information resources

10 1. Introductory remarks on biochemical information resources exploring Life in post-genomic era

11 1. Introductory remarks on biochemical information resources exploring Life in post-genomic era databanks+Bioinformatics= biological knowledge

Bioinformatics genome + algorithm * Sequence Alignment Gene localization Genome reconstruction from fragments Protein structure alignment protein structure prediction prediction of gene expression prediction of protein-protein interaction * algorithm = an algorithm is a step-by-step procedure for calculations. Algorithms are used for calculation, data processing, and automated reasoning. An algorithm is an effective method expressed as a finite list of well-defined instructions for calculating a function Nucleic acids and proteins in one and more dimensions

millions or billions of times 13 (deoxy)nucleotide base DNA 4 bases base TACTG…… 1. Introductory remarks on biochemical information resources

From tens to thousands 14 RNA 4 bases base Uracil U 1. Introductory remarks on biochemical information resources

15 1. Introductory remarks on biochemical information resources

16 1. Introductory remarks on biochemical information resources

hydrogen carbon oxygen sulphur nitrogen amino acid …… …… 3 M L K 4 A 5 W 6 R 7 F 8 D 9 Q Thousands of times more often Introductory remarks on biochemical information resources

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Introductory remarks on biochemical information resources

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21 1. Introductory remarks on biochemical information resources Guided tour of NCBI portal

22 1. Introductory remarks on biochemical information resources Guided tour of NCBI portal

23 1. Introductory remarks on biochemical information resources Guided tour of NCBI portal

24 1. Introductory remarks on biochemical information resources Guided tour of NCBI portal

25 1. Introductory remarks on biochemical information resources Guided tour of NCBI portal

26 1. Introductory remarks on biochemical information resources Guided tour of NCBI portal

27 1. Introductory remarks on biochemical information resources Guided tour of NCBI portal

28 1. Introductory remarks on biochemical information resources Guided tour of NCBI portal