FDA-MANDATED ALTERNATIVE TO BISPHENOL-A Kristina Lenn Kevin Miles Gregory Jackett Isaac Norton August 5, 2010

Foreshadow  Introduction  Effects of BPA on Human Physiology  Possible Alternative Plastics to BPA  Manufacturing Analysis  Conclusion/Recommendation  Questions

Introduction  Nalgene water bottles  BPA usage  FDA regulations

Meet the Team  Kristina Lenn  Project Manager  Bachelor of Science in chemical engineering with an emphasis in biological engineering  Research on molecular modeling and computer simulation  Worked with Nalgene for one year

Meet the Team  Kevin Miles  Team Leader during the Project Proposal  Bachelor of Science in chemical engineering with an emphasis in biological engineering  Research on tissue engineering  Worked with Nalgene for one year

Meet the Team  Gregory Jackett  Team Leader during the Final Presentation  Bachelor of Science degree in chemical engineering with emphasis in molecular engineering and nanotechnology  Research on fatigue-induced muscle injury  Worked with Nalgene for one year

Meet the Team  Isaac Norton  Team Leader during the Final Report  Bachelor of Science in chemical engineering with an emphasis in product and process design  Work experience in quality control  Worked with Nalgene for one year

Background  BPA=Bisphenol-A  Polycarbonate  Chemical in water bottles and pop cans

Problem  Recognized by the human body as estrogen  Absorbed by breast tumor cells  Promote breast and prostate tumor growths

Task  BPA effects  Harmless Alternatives  Manufacturing Techniques

BPA EFFECTS ON HUMAN PHYSIOLOGY Kevin Miles

A Look Ahead…  Previous Statements  Enviornmental exposure to BPA  BPA Leeching  The Endocrine system  BPA linked to cancer  Conclusion

~ 25 ng/kg/day 50,000 ng/kg/day onwardstate.com/wp- content/uploads/2008/12/water_bottle- 300x300.jpg&imgrefurl= /2008/12/20/water-water-everywhere-but-a- storage- dilemma/&usg=__qNetutbQEJVjtGWRfq72AO1L wVU=&h=300&w=300&sz=11&hl=en&start=0&t bnid=WsPcp- pgT6AipM:&tbnh=115&tbnw=114&prev=/imag es%3Fq%3DWater%2BBottle%26um%3D1%26hl %3Den%26sa%3DN%26rlz%3D1G1GGLQ_ENUS 367%26biw%3D740%26bih%3D411%26tbs%3Di sch:1&um=1&itbs=1&iact=rc&dur=244&ei=xTV PTOe5HZKlnQemi6CQBw&page=1&ndsp=10&ve d=1t:429,r:6,s:0 Human Exposure: 52-74ng/kg/day

How does the endocrine system work?

 BPA increased the level of hormone receptors produced by a prostate gland cell  Some dosages of BPA were environmentally relevant

 An increase in cell receptors fuels growth of the cell  Cells can proliferate out of control, resulting in cancerous tumor cells.

Conclusions  BPA is harmful in lower doses  BPA can leech into food/beverages at relevant levels  BPA exposure increases risk of cancer

ALTERNATIVE POLYMERS Gregory Jackett

The Line up  The Candidates  Strength  Toughness  Liquid Stability  UV Stability  Thermal Stability  The Ranking

PETE(Polyethylene terephthalate)

Atactic Polystyrene(PS)

Eastman Tritan Copolyester

Strength

Toughness

Liquid Stability

UV Stability Copolyester?

Thermal Stability

The Ranking Copolyester PETE Polystyrene

MANUFACTURING ANALYSIS Isaac Norton

Forecast  Polymerization Method  Safety  Quality  Retooling  Ranking

Method

Safety

Reaction Heat Runaway

Quality

The Ranking Copolyester PETE Polystyrene

Conclusions  Hazardous in small concentrations  Carcinogenic developmental changes  Copolyester’s better material properties  PETE’s better safety and quality properties

Our Solution Is… PETE

Just a Reminder…  The Problem  BPA Effects  Possible Alternatives  Manufacturing Comparison  The Solution

References B0DF5064/0/example_lrg_camelbak1.jpg

References /middle/middle14.jpg Taylor & Francis Group. (2010) Polymers, a property database. Retrieved from

QUESTIONS?