Presented By Patrick Wen at 2014 ASCO Annual Meeting

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Presentation transcript:

Presented By Patrick Wen at 2014 ASCO Annual Meeting A randomized, double‑blind, placebo-controlled phase 2 trial of dendritic cell (DC) vaccination with ICT-107 in newly diagnosed glioblastoma (GBM) patients Presented By Patrick Wen at 2014 ASCO Annual Meeting

Rationale for Immunotherapy in GBM Presented By Patrick Wen at 2014 ASCO Annual Meeting

ICT-107 is an Autologous Six-antigen DC Vaccine Presented By Patrick Wen at 2014 ASCO Annual Meeting

ICT-107 Phase I Highlights from ASCO 2013 Presented By Patrick Wen at 2014 ASCO Annual Meeting

Presented By Patrick Wen at 2014 ASCO Annual Meeting ICT-107 Ph II Trial Design Presented By Patrick Wen at 2014 ASCO Annual Meeting

Eligibility Criteria and Objectives Presented By Patrick Wen at 2014 ASCO Annual Meeting

Presented By Patrick Wen at 2014 ASCO Annual Meeting Patient Disposition<br />October 2013 and April 2014 Data Analysis Presented By Patrick Wen at 2014 ASCO Annual Meeting

Presented By Patrick Wen at 2014 ASCO Annual Meeting Patient Demographics Presented By Patrick Wen at 2014 ASCO Annual Meeting

Safety – Common Adverse Events Presented By Patrick Wen at 2014 ASCO Annual Meeting

Presented By Patrick Wen at 2014 ASCO Annual Meeting Safety – SAEs Above Grade 3<br />Active Patients and Control Patients Presented By Patrick Wen at 2014 ASCO Annual Meeting

Presented By Patrick Wen at 2014 ASCO Annual Meeting OS (From Randomization) for ITT and PP Populations<br />Updated in April 2014 Presented By Patrick Wen at 2014 ASCO Annual Meeting

Presented By Patrick Wen at 2014 ASCO Annual Meeting PFS for the ITT and PP Populations <br />(Central Radiology Review)<br />Updated in April 2014 Presented By Patrick Wen at 2014 ASCO Annual Meeting

Presented By Patrick Wen at 2014 ASCO Annual Meeting MGMT Status Creates Two Different Patient Populations From the Survival Perspective<br />Per-Protocol Population with April 2014 Survival Data Presented By Patrick Wen at 2014 ASCO Annual Meeting

Presented By Patrick Wen at 2014 ASCO Annual Meeting OS in the Unmethylated MGMT and HLA-A2† Subgroup<br />Per-Protocol Population with April 2014 Survival Data Presented By Patrick Wen at 2014 ASCO Annual Meeting

Presented By Patrick Wen at 2014 ASCO Annual Meeting PFS in the Unmethylated MGMT and HLA-A2 Subgroup (Central Radiology Review)<br />Per-Protocol Population with April 2014 PFS Data Presented By Patrick Wen at 2014 ASCO Annual Meeting

Presented By Patrick Wen at 2014 ASCO Annual Meeting OS in the Methylated MGMT and HLA-A2 Subgroup<br />Per-Protocol Population with April 2014 Survival Data Presented By Patrick Wen at 2014 ASCO Annual Meeting

Presented By Patrick Wen at 2014 ASCO Annual Meeting PFS in the Methylated MGMT and HLA-A2 Subgroup<br />(Central Radiology Review)<br />Per-Protocol Population with April 2014 PFS Data Presented By Patrick Wen at 2014 ASCO Annual Meeting

Quality of Life Assessed via FACT-BR and Performance Status Presented By Patrick Wen at 2014 ASCO Annual Meeting

Proportion of Steroid Usage During Trial Presented By Patrick Wen at 2014 ASCO Annual Meeting

Presented By Patrick Wen at 2014 ASCO Annual Meeting Relationship between Indicators of Vaccine Potency and Survival<br />Cox Proportional Hazards Model – Assessments of DC Maturity and Activation in Vaccine Prior to Administration Presented By Patrick Wen at 2014 ASCO Annual Meeting

Antigen-Specific Vaccine Response Presented By Patrick Wen at 2014 ASCO Annual Meeting

Presented By Patrick Wen at 2014 ASCO Annual Meeting Antigen Presentation in Primary Tumors<br />Percent of Patients Expressing Antigens via qPCR<br /> Presented By Patrick Wen at 2014 ASCO Annual Meeting

Conclusions for ICT-107 Ph II Presented By Patrick Wen at 2014 ASCO Annual Meeting

Presented By Patrick Wen at 2014 ASCO Annual Meeting Acknowledgements Presented By Patrick Wen at 2014 ASCO Annual Meeting