Glycoproteins and Proteoglycans Eric Niederhoffer SIU-SOM Glycoproteins Proteins conjugated to saccharides lacking a serial repeat unit Proteoglycans Proteins.

Slides:

Advertisements

Similar presentations

ESSENTIALS OF GLYCOBIOLOGY LECTURE 14 DEGRADATION AND TURNOVER OF GLYCOCONJUGATES Hud Freeze.

Advertisements

Lecture 6 O-GalNac Glycans C-type Lectins. The Glycome is Rich.

CARBOHYDRATES: STRUCTURE AND FUNCTION

CARBOHYDRATES Chemistry (Chapter 7).

Discussion 8 Hyaluronan, Sulfated Glycosaminoglycans & Glycosaminoglycan Binding Proteins.

Carbohydrates: Oligosaccahrdes and Polysaccharides.

Essentials of Glycobiology Lecture 5 April 6, 2004 Ajit Varki N-Glycans Asparagine (N)-linked oligosaccharides N-linked Glycans N-linked Sugar Chains.

CARBOHYDRATES: STRUCTURE AND FUNCTION By Dr. Amr S. Moustafa, MD, PhD.

Biochemistry Sixth Edition

Carbohydrates Polysaccharides Dr. Nikhat Siddiqi.

Prentice Hall c2002Chapter 81 Chapter 8 - Carbohydrates Carbohydrates (“hydrate of carbon”) have empirical formulas of (CH 2 O) n, where n ≥ 3 Monosaccharides.

Glycoconjugates Carbohydrates covalently linked to a protein or lipid act as informational carrier in: cell-cell recognition, cell-cell adhesion, cell.

Cell Surface Heparan Sulfate Proteoglycans O O OX CH 2 OX NHY O COOH O OH O Cells adapt structures of surface HS chains in response to their environment.

Chapter 8 (part2) Carbohydrates: oligo- and polysaccharides.

Carbohydrates. 1. Energy source for plants and animals 2. Source of carbon in metabolic processes 3. Storage form of energy 4. Structural elements of.

Carbohydrates Polysaccharides Dr. Nikhat Siddiqi.

Extracellular Macromolecules

STRUCTURE AND FUNCTION OF CARBOHYDRATES (SUGARS) Azin Nowrouzi (PhD)

Glycosaminoglycans Dr Amena Rahim.

L/O/G/O Polysaccharides By Dr. Batoul Izzularab 4 3.

Essentials of Glycobiology March 30th, 2004 Ajit Varki Lecture 1 Course Overview & General Introduction.

Carbohydrates (also called saccharides) are—on the basis of mass—the most abundant class of biological molecules on Earth. Although all organisms can.

Dental Biochemistry Lecture 45 Carol Lutz, PhD Complex Carbohydrates: Glycoproteins and Proteoglycans.

Carbohydrates II; Lipids I Andy Howard Introductory Biochemistry 28 February 2008.

SYNTHESIS OF GLYCOPROTEINS Dr. Nasim AP BIOCHEMISTRY.

Dr. Saidunnisa Professor of Biochemistry Carbohydrates-II.

Carbohydrate structure and function PTT 103: Biochemistry Department of Chemical Engineering Technology, UniMAP Semester 1, 2013/2014

FOOD CHEMISTRY BY PONDICHERRY UNIVERSITY II lecture 2/August/2012

Carbohydrates and Glycobiology

Carbohydrates. Structure and Function How do we define a carbohydrate? aldehydes or ketones with multiple hydroxyl groups “hydrate” of carbon – C-H 2.

Chapter 7 Carbohydrates and Glycobiology. Carbohydrates are everywhere

THE STRUCTURE OF CARBOHYDRATES

Carbohydrates are polyhydroxy aldehydes or ketones. They are represented with general formulae C n (H 2 O) n. They are the chief source of energy in human.

Ch. 8: Carbohydrates Ch. 10: Metabolism (intro) Ch. 11: Glycolysis Ch. 12: Other pathyways in carbo. metabolism Exam: Tues Mar 2nd Diseases associated.

Prentice Hall c2002Chapter 81 Chapter 8 - Carbohydrates Carbohydrates (“hydrate of carbon”) have empirical formulas of (CH 2 O) n, where n ≥ 3 Monosaccharides.

LAB. EXERCISE NO. 4 DR. ANSARI CONNECTIVE TISSUE PRELAB.4. BY PROF. DR.ANSARI 1 Sunday, November 22, 2015.

09/22/2009 Biochem: Carbohydrates II Carbohydrates II Andy Howard Introductory Biochemistry, Fall September 2009.

GLYCOPROTEINS Dr Amina Tariq Biochemistry. Glycoproteins Glycoproteins are proteins that contain oligosaccharide (glycan) chains covalently attached to.

Sugar acids Prof. Sylvester L.B. Kajuna

Glycosaminoglycans and

CARBOHYDRATES PART 2 ECDA Aug DISACCHARIDES.

BIOCHEMISTRY OF CARTILAGE

Glycoproteins and Mucins B.Sopko. Content Glycoproteins: Structures and Linkages Interconversions and activation of dietary sugars Other pathways of sugar.

Lecture 12 Web: pollev.com/ucibio Text: To: Type in:

Carbohydrates: structure and Function

Carbohydrates serve a variety of functions Energy storage and food Structure and support Lubrication Protection Recognition and signaling Component of.

POLYSACCHARIDES 1. Homopolysaccharides D-glucose Amylose

EXTRACELLULAR MATRIX. Extracellular matrix (ECM)  cells (mesenchymal origin) - fibroblasts - smooth muscle cells - chondroblasts - osteoblasts and epitelial.

Sugars Alice Skoumalová.

Refresher of the structure of carbohydrates

CARBOHYDARTE II Done By :Nisreen Moh’d

Lecture 12 Web: pollev.com/ucibio Text: To: 37607

Glycobiology Introduction to Glycobiology Glycan structures

Glycosaminoglycan Modulates Growth Factor Signaling (Heparan Sulfate and VEGF) Glycobiology 2007 Cholrate is an inhibitor of activated sulfate synthesis.

EXTRACELLULAR MATRIX Jana Novotná.

CONJUGATED PROTEINS.

Carbohydrates: structure and Function

Glycobiology resources

Proteoglycans are conjugates of proteins and glycosaminoglycans

Carbohydrates Harini Chandra

Carbohydrate Chemistry Part 2: Other Carbohydrates

Glycosyltransferases and Glycosidases

Macromolecules & Carbohydrates

Macromolecules & Carbohydrates

Figure 16.1 Oxidative phase of the pentose phosphate pathway: formation of pentose phosphate and NADPH. Textbook of Biochemistry with Clinical Correlations,

Sheet #7 Lecture (Glycoproteins Lecture Part 1) Lecture Date :

Complex Carbohydrates Glycosaminoglycans(GAGs)

Rahul Raman, V. Sasisekharan, Ram Sasisekharan Chemistry & Biology

Profiling the Sulfation Specificities of Glycosaminoglycan Interactions with Growth Factors and Chemotactic Proteins Using Microarrays Eric L. Shipp,

Sugars 10/29/09.

Presentation transcript:

Glycoproteins and Proteoglycans Eric Niederhoffer SIU-SOM Glycoproteins Proteins conjugated to saccharides lacking a serial repeat unit Proteoglycans Proteins conjugated to polysaccharides with serial repeat units Protein >> carbohydrate Carbohydrate >> protein Glycosaminoglycans Mucopolysaccharides Repeat unit HexN and HexUA

Glycopeptide bonds Type I Type IIType III N-Glycosyl linkage to Asn O-Glycosyl linkage to Ser (Thr)O-Glycosyl linkage to 5-HOLys Glc NAc Asn Glc NAc Ser HOLys Glc

Glycosaminoglycans Hyaluronate No protein link No sulfate  -1,3 glycosidic linkage GlcUAGlcNAc  -1,3  -1,4

Glycosaminoglycans Chondroitin sulfate GlcUA-Gal-Gal-Xyl-O-Ser link Sulfate at 4 or 6 C of GalNAc  -1,3 glycosidic linkage GlcUAGalNAc  -1,3  -1,4

Glycosaminoglycans Dermatan sulfate IdUA with some GlcUA Sulfate at 4 or 6 C of GalNAc  -1,3 glycosidic linkage IdUAGalNAc  -1,3  -1,4

Glycosaminoglycans Heparin GlcN and GlcUA or IdUA N and O sulfate (C2,3,6)  -1,4 glycosidic linkage GlcUAGlcNAc  -1,4 Heparan sulfate > NAc < N and O sulfate

Glycosaminoglycans Keratan sulfate I GlcNAc and Gal (no UA) Sulfate on C6 of Gal or HexN  -1,4 glycosidic linkage GlcUAGlcNAc  -1,4  -1,3 Keratan sulfate IIGalNAc-O-Ser or Thr