Auburn University MRI Research Center

Facility Overview ● Three story – 45,000 SF building ● MRI systems ■ 3 Tesla (T) open-bore whole body ■ 7T whole body ● Designed to support research and clinical operations ■ Animal facilities Short-term holding facility Minimally-invasive procedures area ■ Training for faculty/staff/students ● Funded by a $21M State bond issued in 2007

Auburn University Objectives ● Increase AU research funding ■ Establish AU as a leader in MRI research ■ Enhance AU’s reputation as a major research university ■ Attract businesses/industries to the AU Research Park ● Provide additional healthcare capabilities for the region

AU MRI Research Center ● Partnership between ■ Auburn University ■ Siemens Healthcare ■ East Alabama Medical Center ■ Alabama Imaging Inc. ■ University of Alabama at Birmingham (UAB) ■ International Central South University (China) Siemens Corporate Technology (China)

Auburn Research Park

First Floor

Second Floor AU Research The Orthopaedic Clinic USAARL

Third Floor Rehab Works – EAMC AU Kinesiology Auburn Neurosurgery

Proposed Operating Scenario ● EAMC/AI controls 3T and clinical area ■ 8 hours/day (8AM-4PM) Mon-Fri ■ Lease at market value ● AU controls 3T ■ 16 hours/day (4PM-8AM) Mon-Fri ■ 24 hours/day Sat, Sun, holidays ● 7T is research only ■ AU control 24/7

Timeline ● June ‘09 – Order equipment ● July ‘09 – Building design ● July ‘09 – Begin seminar series ● Jan ‘10 – Begin construction ● Summer ‘10 – Begin training ● Sept ‘10 – Construction complete ● Oct ‘10 – 3T/7T install ● Oct ‘10 – Begin 3T operations ● Spring ‘11 – Begin 7T operations

Current and Potential Research Projects ● Coil design & Manufacture ■ Technology commercialization ■ Wireless technology ● Orthopedic Injury/Rehab ■ Auburn Athletics / Andrews Orthopedics ● fMRI/Cognitive Neuroscience ■ Autism ■ Psychology / Human Sciences ● Communication Disorders ■ Audiology ■ Speech Pathology ● Advanced cardiac imaging ■ UAB collaboration (NIH) ● Fat Imaging ■ Diabetes and obesity ● Metabolic/Molecular imaging ■ MRS/MRSI ■ Alzheimer’s disease (NIH)

3T Open-Bore MRI ● FDA certified for clinical use ● 70 cm bore ● 173 cm length

3T Open-Bore MRI

Standard Applications ● Neurology ● Angiography ● Cardiac ● Body ● Oncology ● Orthopedic ● Pediactric ● Scientific

Spine Imaging at 3T ● 4-channel neck coil ● 24-channel spine coil

Axially-Loaded Lumbar Spine MRI

Advanced Applications - DESS ● Increased cartilage/fluid contrast

Advanced Neuro Applications ● fMRI acquisition/analysis ● Diffusion ● Perfusion ● BOLD Imaging ● Advanced Functional Neuro

InVivo Esys fMRI System

7T MRI

MAGNETOM UHF Community (22 sites): 1.Massachusetts General Hospital, Boston, USA Imaging since 08/ Institute for Neuro-Biology, Magdeburg, Germany Imaging since 02/ New York University, NYC, USA Imaging since 03/ Center for MR Research, Minneapolis, USA Imaging with Siemens console since 12/ Gachon Medical School, Seoul, Korea Imaging since 04/ Oregon Health, Portland, USA First images 12/06 7.Erwin Hahn Institute for Magnetic Resonance, Essen, Germany Imaging since 09/ Center for Imaging in Biomedicine, Lausanne, Switzerland Imaging since 11/ Max Plank Institute, Tübingen, Germany (9.4T)  Imaging since 07/ CEA, Paris, France  Imaging since 02/ CEA, Paris, France, 11.7T  to be installed UPMC, Pittsburgh, USA former GE system converted to Siemens Imaging since 05/ Max Plank Institute, Leipzig, Germany Imaging since 07/ Medical University of Vienna, Vienna, Austria Imaging since 04/ DKFZ, Heidelberg, Germany Imaging since 08/ Forschungszentrum Jülich, Germany (9.4T/900) Imaging since 17. HUP, Philadelphia, PA, USA Imaging since 06/ MDC, Berlin, Germany Imaging since 12/ CAS, Beijing, China To be installed in Fall Oxford University, Oxford, UK To be installed in spring Auburn University, Auburn, Alabama, USA To be installed Fall CMRR, Minneapolis, USA To be installed in fall 2010

Other Siemens 7T Installations in USA ● MGH/ Harvard/ MIT ● NYU ● Penn ● Minnesota ● Portland, Oregon ● Pittsburgh

High-Field Imaging T2-weighted imaging of the human hippocampus 1.5T7.0T

Functional MRI (fMRI)

Van der Zwaag, et al, Neuroimage May 14 fMRI at 1.5T, 3.0T, 7.0T

Van der Zwaag, et al, Neuroimage May 14 fMRI at 1.5T, 3.0T, 7.0T

7.0T1.5T Behr, et al, Skeletal Radiol Sep;38(9):911-7

7.0T1.5T Behr, et al, Skeletal Radiol Sep;38(9):911-7

Spatial Resolution 3T7T fMRI BOLD3.0 / 2.5 mm / 3.0 mm 3 Brain 0.5 / 1.0 mm / 1.0 mm / 2.0 mm / 0.7 mm 5 Musculoskeletal0.30 / 2.0 mm / 1.0 mm 1 1.Regatte, et al, JMRI Vol.25, 2 Pages: Kuhl, et al, Radiology Apr;247(1): Yacob, et al, Neuroimage October 1; 37(4): 1161– Nakada, Brain and Development,29 (6), July 2007, Thomas, et al, JMRI 2008 November; 28(5): 1266– Miller, et al, J Neurophysiol 99: , Wiggins, et al, Magn Reson Med, 56(1), , 2006

Spectroscopy ● Proton spectroscopy (3T and 7T) ■ Single voxel ■ Chemical shift imaging ● Multinuclear spectroscopy (7T only) ■ 7 Li, 13 C, 17 O, 19 F, 23 Na, 31 P

MRI - Coils

Small Rodent MRI

Small Animal MRI

Fat Imaging

Fat Detection & Quantification