Cytokine Signaling. Types of receptors Protein tyrosine kinase receptors with intrinsic kinase activity –Insulin, EGF, PDGF, CSF-1 etc. Protein serine.

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Presentation transcript:

Cytokine Signaling

Types of receptors Protein tyrosine kinase receptors with intrinsic kinase activity –Insulin, EGF, PDGF, CSF-1 etc. Protein serine kinase receptors with intrinsic kinase activity –MIS, TGF , activin, inhibin etc. Receptors without intrinsic kinase activity –This is the large, heterogeneous group called the cytokine receptor super family G-protein coupled receptors and ion-gated receptors

Types of receptors

Protein tyrosine kinase receptors

PTK receptor activating MAP kinase pathway

PTK receptor activating Pi-3 kinase pathway

SH2 domain containing protein: recognition of phosphotyrosines

PTK signaling: 1 o and 2 o signals

Cytokine signaling mechanisms Cytokines represent a diverse number of molecules. The super family of cytokine receptors more specifically refers to those cytokines that signal via the Jak-STAT pathway These include Interleukins 2, 3, 4, 5, 6, 7, 9, 11, 12, 13, & 15, and G-CSF, LIF and the interferons In addition, growth hormone, prolactin, erythropoietin, leptin, thrombopoietin Many growth factor signal pathways cross-communicate with the STAT pathway.

General scheme for all MAP- kinase pathways

Receptor activation of intracellular signaling pathways

PTK vs. cytokine pathways

G-protein coupled receptors

Cytokines and Leydig cells Overview and significance of Immune-endocrine interactions in the regulation of Leydig cell function Immune-Endocrine control of Leydig cell function