Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man.

Slides:



Advertisements
Similar presentations
1978 Fibronectin shown to colocalize with fibrillar actin. Proposed a transmembrane relationship between microfilaments and FN First evidence of affinity.
Advertisements

CELL COMMUNICATION. YOU MUST KNOW… THE 3 STAGES OF CELL COMMUNICATION: RECEPTION, TRANSDUCTION, AND RESPONSE HOW G-PROTEIN-COUPLED RECEPTORS RECEIVE CELL.
Embryology Behrouz Mahmoudi Molecular Signaling 1.
Cell Communication Chapter 11. Types of Cell Signaling  Local Regulators – molecules released travel short distances to other cells in the area  Examples:
Chapter 5 Ligand gated ion channels, intracellular receptors and phosphorylation cascades.
CELL CONNECTIONS & COMMUNICATION AP Biology Ch.6.7; Ch. 11.
Lecture 23 Signal Transduction 2
Signaling and the Signal Transduction Cascade. Question?????? External Stimulus Inside cell Nucleus, Gene transcription Other cellular effects.
BioSci 145A lecture 18 page 1 © copyright Bruce Blumberg All rights reserved BioSci 145A Lecture 18 - Oncogenes and Cancer Topics we will cover today.
Hedgehog signaling pathway Indian hedgehog: expressed in gut and chondrocytes Desert hedgehog: expressed in sertoli cells of the testes Sonic hedgehog:
Targil – Signal transduction.
Signal Pathways in Eukaryotic Cells Overview. Lipid Soluble Hormones.
Cell Communication III. G-protein linked receptor.
RET Proto- Oncogene in The Development of Thyroid Cancer: Multiple Endocrine Neoplasia Type 2 Courtney Brooks.
Cell Signaling A __________________________is a series of steps by which a signal on a cell’s surface is converted into a ________________________________________________.
Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer
The 3 Steps.  Intracellular Receptors ◦ Proteins in the cytoplasm or in the nucleus ◦ Example: transcription factors  Receptors in the Plasma Membrane.
Manifestation of Novel Social Challenges of the European Union in the Teaching Material of Medical Biotechnology Master’s Programmes at the University.
B. Signal Transduction Pathway (cell signaling)
Cell-cell Communications in Development
Β-Catenin, Cancer, and G Proteins Not Just for Frizzleds Anymore Ming Yang et al. PNAS Maria Domenica Castellone et al. Science
Wnt signaling in development and disease Vítězslav Bryja, PhD. Institute of Experimental Biology Faculty of Science, Masaryk University Brno, Czech Republic.
Copyright © 2005 Pearson Education, Inc. publishing as Benjamin Cummings PowerPoint Lectures for Biology, Seventh Edition Neil Campbell and Jane Reece.
 Regulation of Cell Number and Cancer Cells Special Limited Edition Packet Tuesday, November 10,
Extracellular signal molecule
Hybrid Functional Petri Net model of the Canonical Wnt Pathway Koh Yeow Nam, Geoffrey.
Chapter 11 Cell Communication. Concept Check Questions Chapter 11 Cell Communication.
Cell Communication.
Cell Communication Chapter 11.
Cell Signaling. Local Signaling Paracrine Paracrine Synaptic Synaptic.
 Signaling molecules that function within an organism to control metabolic processes within cells, the growth and differentiation of tissues, the synthesis.
Signaling Machinery The Signals The Receivers
Cell Communication (Chpt. 11) Chapter 11. Overview of Cell Signaling Signaling evolved early in history of life Communicating cells may be close together.
JAK-STAT Signaling Pathway.
Specialized cell signaling pathways 2
Chapter 11: Cell Communication. Cell to cell recognition: Yeast cells: secrete chemical signals which bind to specific receptors Start to grow towards.
You Must Know  3 stages of cell communication Reception, transduction, & response  How G-protein-coupled receptors receive cell signals & start transduction.
Chapter 11 Cell Communication. Cell communication signal cells communicate by direct contact or by secreting local regulators ex: growth factors, neurotransmitters.
Chapter  Differentiate between the following:  Paracrine  Endocrine  Autocrine.
Please turn in the Unknown Solutions Lab Remember: We will vote on T-shirt designs on Monday.
Fibroblast Growth Factors (FGFs)
Chapter 14: Signaling Pathways That Control Gene Activity
Negative regulation of cell cycle by intracellular signals Checkpoint p53 detects DNA damage & activates p21 p21 inhibits cdk2-cyclinA Intracellular Regulation.
Genes in development Signal transduction pathways and
Responding to environmental signals Inter-cellular communication—driving cell division.
Signaling Pathways Ligands, Receptors, Binding, and Cascades Naralys Batista January 7, Funding for this workshop was provided by the program “Computational.
16:00 PM on Jan 08 (Tue) Engineering Building 1, Room711 Prof. Tae Joo Park(2582) Speaker : Cheol-Hee Kim, Ph.D. Department of Biology,
Epidermal growth factor receptor tyrosine kinase inhibitors as initial therapy for non- small cell lung cancer: Focus on epidermal growth factor receptor.
Cell Communication Chapter 11.
Cellular Signaling Ch. 11.
Chapter 11 – Cell Communication
Cell Communication Review
Concept 4: Analyzing Cell Communication
Figure 2 Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis Figure 2 | Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis.
Cell Communication Lecture 4 Fall 2008
Cell Communication.
Cell Communication REVIEW.
Signaling Machinery The Signals The Receivers
Cell Communication (1.4) – Part 1
Cell to Cell Communication via Enzyme Linked Receptors
Cell Communication.
Figure 5 Drugs that target WNT signalling
Figure 1 WNT signalling pathways
Cell Communication CHAPTER 11.
Cell Communication (Signaling) Part 3
The LDL Receptor Gene Family
Cell Communication (Signaling) Part 3
11.2 Cell Communication.
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
Presentation transcript:

Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

Wnt pathway Ligands Receptors Intracellular components Transcription factors Interactome

Wnt “Wnt” is a combination of Wg (wingless) gene in Drosophila and Int gene in MMTV, two homologous genes Wnt are secreted proteins 19 Wnt genes in humans and mice

Wnt Receptors Receptor tyrosine kinase Derailed/RYK ROR Frizzled-transmembrane receptor LRP (lipoprotein-receptor related protein) Single-pass Tm proteins Cytoplasmic tail phosphorylated by GSK3 and CK1 

Wnt Pathway

Wnt signaling

Interactions: Intracellular Components

Intracellular Components

Canonical/Non-canonical Wnt pathway

Wnt Pathway Interactome

Wnt pathway interactions

Role of Wnt signaling

Development Neural development: CNS Neural crest Limb Tumor formation Cellular growth and proliferation

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2025 SlidePlayer.com. Inc. All rights reserved.