Yeast - why it simply has a lot to say about human disease.

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Presentation transcript:

Yeast - why it simply has a lot to say about human disease

Genetic mutations identified in human disorders

A richness of data allows yeast to tell a multi-dimensional story Zhu, et al. (2012), Stitching together multiple data dimensions reveals interacting metabolomic and transcriptomic networks that modulate cell regulation. PLoS Biology metabolites genes genes w/cis-eQTLs Leu3p binding sites

Human connections into SGD Homology & Disease X Functional Complementation Phenotypes & Orthology Literature Drug Interactions

Searchable Connections gene name

Searchable Connections yeast gene

Searchable Connections human gene

disorder Searchable Connections

A real and present connection

NGLY1 SGD’s Advanced Search

A real and present connection yeast PNG1 phenotypes function pathways literature protein properties genetic interactions NGLY1 SGD’s Advanced Search

Connection start points Human genes Yeast homologs Function known, human homologs Yeast genes 4500 genes 1340 diseases 2750 genes

SGD: Powering Connections