The Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Linda-Gail Bekker The implementation of this project was made possible through an unrestricted grant from ViiV Healthcare. The content and structure of the project has been guided by paediatric experts convened by the IAS.

CIPHER Vision Goal Optimizing clinical management and delivery of services to infants, children and adolescents affected by HIV in resource- limited settings, through advocacy and research promotion. Objectives  Addressing targeted research gaps to optimize service delivery and clinical management  Strengthening paediatric HIV cohort collaboration to inform policy decisions  Advocacy and outreach to support evidence-informed clinical, policy and programmatic decision making (new 2014)

Background 2012: CIPHER founded as 2-year flagship IAS paediatric initiative  Unrestricted educational grant from ViiV Healthcare of £1.5 M  Guided by paediatric HIV experts convened by the IAS Activities developed 2012 – 2013  Needs Assessment: –clinical and operational research gaps  Research Grant Programme  Global Cohort Collaboration  Online Paediatric HIV Cohort Database  JIAS Special Issue: Perinatally HIV-infected Adolescents End 2013: Paediatrics an IAS priority, branded as CIPHER  CIPHER re-funded for : £1.5 M from ViiV Healthcare : Continue and build on current activities, new activities

Research Grant Programme Clinical and Operational research projects with the potential to contribute to the optimization of HIV diagnosis, prevention, treatment and care for infants, children and adolescents affected by HIV in resource-limited settings For early stage investigators Research in resource- limited settings 75,000 USD/year - up to two years This programme was made possible thanks to support of an unrestricted educational grant form ViiV Healthcare.

2014 CIPHER GRANTEES Tavitiya Sudjaritruk, Research Institute for Health Sciences, Chang Mai University, Thailand, for research in Thailand Liver injury and long-term metabolic complications among perinatally HIV-infected children and adolescents receiving antiretroviral therapy Eric McCollum, John’s Hopkins School of Medicine, USA, for research in Malawi Bubble CPAP treatment in hospitalized African infants failing standard pneumonia care in a high HIV prevalence country

CIPHER is pleased to announce a new round of PAEDIATRIC HIV RESEARCH GRANTS For 2015 Applications open from 1 to 31 October The implementation of this project is made possible through an unrestricted grant from ViiV Healthcare. The content and structure is guided by experts in paediatric HIV convened by the IAS.

CIPHER Cohort Collaboration  Paediatric HIV Cohort Investigator Consultation, May 2013  Participating cohorts/networks  IeDEA (Southern, Central, West and East Africa; CCASAnet; TREAT Asia)  EPPICC (including PMTCT and Eastern European cohorts)  Médecins Sans Frontières (MSF)  Baylor International Pediatric AIDS Initiative (BIPAI)  International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1074  Pediatric HIV/AIDS Cohort Study (PHACS)  Optimal Models/ICAP

CIPHER Cohort Collaboration  Priority research topics  Time on first-line ART: Estimate incidence of treatment switch to second-line ART and associated factors; describe regimen use and durability  Adolescent epidemiology: Describe the global epidemiology of perinatally HIV-infected adolescents and compare outcomes across regions  To be studied through a new, global pediatric cohort collaboration, supported by CIPHER ( )  Data and analysis centres  CIDER (IeDEA Southen Africa), South Africa  MRC UCL (EPPICC), UK  CBAR HSPH (PHACS), USA ~ 250,000 infants, children and adolescents affected by HIV

Paediatric HIV Cohort Database  Online, searchable database  Platform for cohort collaboration  Source of information for researchers, funders, policy makers Launched on World AIDS Day, Dec 2013 To date:  30 cohorts/networks, representing ~250,000 infants, children and adolescents in 59 countries  389 unique visitors, 742 total visits, from 50 different countries Next steps and ideas:  Analysis tools: Summary tables, epidemiology tool...  Additions: Link to online paediatric HIV resource library (with UNICEF)

Future directions and next steps  Continue and build on current programmes  Grant programme  Global cohort collaboration  Online database  JIAS Special Issue  Adolescent Working Group: Paediatric and adult cohort investigators  Viral Load Monitoring Working Group and Early Infant Diagnosis (paediatric focus)  IAS/ILF-CIPHER Roundtable Discussions  IAS 2015/ work-up to AIDS 2016