The Measurable Difference BioPhotonic Scanner lifepak® nano g3™ Superfruit Blend

The Pharmanex® BioPhotonic Scanner

Health depends on the balance between free radicals and antioxidants Free Radicals & Antioxidants Health depends on the balance between free radicals and antioxidants Free Radicals Anti-oxidants

Antioxidant Health Benefits Journal of the American Medical Association “… low levels of the antioxidant vitamins (vitamins A, E, and C) may increase risk for several chronic diseases. Most people do not consume an optimal amount of all vitamins by diet alone.” “It appears prudent for all adults to take vitamin supplements.” As a result of nationwide nutritional intake surveys, and research in the last decade on antioxidant vitamins, the Journal of the American Medical Association released a landmark editorial in June of 2002 recommending that ALL adults take vitamin supplements. Robert H. Fletcher, MD, MSc; Kathleen M. Fairfield, MD, DrPH, Harvard University Journal of the American Medical Association 2002; 287: 3127-3129

Pharmanex BioPhotonic Scanner Extraordinary Science… Personalized Measures your personal antioxidant protection Measure antioxidant effect of LifePak & G3 in your own body! Easy & non-invasive Scientifically and clinically validated Gold standard – superior to blood measurement and ORAC testing Another validation of LifePak, which you are probably more familiar with, is the BioPhotonic scanner. This is a way that our distributors and contacts can prove the effects of LifePak in their own body. Pharmanex has completed three clinical studies, with more in progress, to validate the biophotonic measurement as an important health indicator, and to validate the effect of LifePak on Scanner scores. Scanner is superior to ORAC. ORAC is not measured in vivo (inside the body), biased towards water-soluble antioxidants, does not measure synergistic effects, does not measure indirect effects on intrinsic antioxidant defense system, more ORAC is not always better

Extraordinary Science… Revolutionized Invented by Physicists at U. Utah Patent rights licensed to Pharmanex Measures carotenoid antioxidants in skin important group of antioxidants part of the antioxidant defense system in the body good indicator of your overall antioxidant status Based on Raman spectroscopy

“I see a future where the BioPhotonic Scanner becomes the gold standard for measuring antioxidant status.” – Dr. Joseph Chang President of Pharmanex February 2003

Carotenoid Correlation Study June 2004 Less variable than gold standard!

Cumulative data suggests scanner is superior to blood testing and ORAC Major University clinical study confirms what we’ve all been waiting for: Skin carotenoid Score (SCS) is an indicator of overall antioxidant status and oxidative stress in the body is a better indicator of fruit and vegetable intake than blood carotenoids Cumulative data suggests scanner is superior to blood testing and ORAC

Double-Blind, Placebo-Controlled LifePak Supplementation Study Question: Does Scanner score reflect increases of all antioxidants in the body? 53 subjects for 6 weeks LifePak or Placebo Measure Scanner response and blood antioxidants Study just finished (summer 2005). To be published next year.

Blood Vitamin C Scanner Response Blood Carotenoids Blood Vitamin E In only 6 weeks, a 7,000 unit increase in scanner score was observed with LifePak (dark blue), and no changes in placebo (light blue). The blood antioxidants (vitamins C and E, and carotenoids) all increased together with the scanner score. Therefore, the scanner is a good reflection of not only carotenoids but also other antioxidants in the body when taking LifePak. But also note that the scanner response occurs a little later (6-week), while blood levels already reach their maximum at 3 weeks. This is what we want to see, because we are interested in the long-term antioxidant status of a person, not in what they just ate a few days ago. This is another reason why the scanner is better than blood measurements. p<0.05 p<0.05 Blood Carotenoids Blood Vitamin E

Accepted by the Scientific Community New York Academy of Sciences, Feb 2003 Oxygen Club of California, Feb 2003 and Feb 2004 FASEB/American Society of Nutritional Sciences - April 2003 and April 2004 Gordon Research Conference, Jan 2004 American College of Nutrition, October 2004 Society for Free Radical Research (ISNA-SFRR), June 2005 Pharmanex Scientists have presented the science behind LifePak and the BioPhotonic scanner and attended a number of scientific meetings this past year. At all of these prestigious scientific meetings, our presentations were well received by even the most critical scientists. In fact, we never received any criticism of our research. Instead, researchers are begging us for supplying scanners for their own laboratories and clinics.

2005 American Business Awards The 2005 American Business Awards is the first national, all-encompassing business awards show, governed by a board of distinguished judges and advisors. The award has been called "the business world's own Oscar Awards" by The New York Post. Pharmanex was awarded a 2005 American Business Award at the annual American Business Awards ceremony in New York City on June 6. Nu Skin Enterprises won the award in the Most Innovative Company category for the Pharmanex® BioPhotonic Scanner, a unique nutritional testing tool developed by Nu Skin Enterprises' Pharmanex division. The award was given in recognition of the Pharmanex® BioPhotonic Scanner for the Most Innovative Company among contenders with more than 2,500 employees, competing against other finalists Oracle Corporation and PACCAR Inc. Last year's winner in the same category was United Parcel Service (UPS). Nu Skin Enterprises was recognized among other top companies that included AT&T, Procter & Gamble, Sprint, and Intuit and was the only direct selling company to receive a 2005 American Business Award. Biophotonic Scanner wins in the Most Innovative Company category

Coming Soon: The New S2

Extraordinary Science… Simplified 50 % lighter 60 % smaller

Extraordinary Science… Simplified Warm up time 30 min 5 min Calibration time 17 min 4 min Calibration steps 9 scans 3 scans Weight of scanner 10 lbs ~5 lbs Scan time 3 min ~2 min Temperature range 70 – 75 °F 50 – 95 °F Scan more people in more places in no time at all.

LifePak Nano takes LifePak to a completely new level LifePak Nano takes LifePak to a completely new level. Pharmanex is raising the bar for multi-nutrient supplements.

What is lifepak nano? A comprehensive nutritional wellness program delivering the optimum amounts of all essential and generally beneficial nutrients for long-term health and well-being. LifePak is not a typical multivitamin. LifePak is much more than that, as you will see in this presentation. LifePak is a comprehensive nutritional wellness program delivering the optimum amounts of all essential and generally beneficial nutrients for long-term health and well-being. LifePak is unique, because it is a complete wellness supplement!

lifepak nano: 8 Formulas in 1 Complete, Balanced and Convenient Multi Vitamin Mineral Anti- oxidant Formula Glucose Metabolism Formula Bone Formula > Anti Aging Formula Immune Nutrient Formula Cardio- Vascular Formula Finally, LifePak is a highly convenient and comprehensive product. It has many more benefits than these supplements together, and ultimately costs a lot less too. If you go into a health food store and try to match LifePak’s composition with individual products, you can easily spend more than $200/month, and you still will not achieve the balance and quality of LifePak. (Explain each health benefit/formula…)

New Vitamin E Minerals Red Wine Polyphenols Nano- Nutrients Nano-CoQ10 Highly Effective Minerals Red Wine Polyphenols Nano- Nutrients Nano-CoQ10 Here is an easy way to summarize what LifePak Nano is all about. (click animation) We basically start with the formula of LifePak Prime, (click animation) then we added the highly bioavailable nano-antioxidants, (click animation), included a full dose of MarineOmega (click animation), new and highly effective sources of vitamin E and bone minerals, (click animation) and finally we added all the benefits of red wine.

What is Nanotechnology? Nano-Switch Most people have heard about nanotechnology, but few really know what the term means. My shirt claims to use nanotechnology and Apple’s new iPod is so small that they called it nano. True nanotechnology must fulfill two requirements. First it must be smaller than 100 nanometers. A nanometer is one billionst of a meter long. Most molecules are between 1 and 100 nm in size. The second requirement of nanotechnology is that substances are manipulated at the molecular level. So simply grinding up vitamin C to nano-size does not qualify. And the iPod nano won’t either. iPod nano? Nanotube Wires nanotech shirt

A Matter of Size Red Blood Cell 100 nanometers 6000 nanometers Nanotechnology first has to do with size. 1 nanometer is one billionth of a meter. To illustrate this, here is an electron microscopic image of a human red blood cell. It is 6000 nanometers in diameter. This small yellow dot here is 100 nm in diameter, and anything smaller than this dot is in the nanotechnology range. True nanotechnology must fulfill two requirements. First it must be smaller than 100 nanometers. A nanometer is one billionst of a meter long. Most molecules are between 1 and 100 nm in size. The second requirement of nanotechnology is that substances are manipulated at the molecular level. So simply grinding up vitamin C to nano-size does not qualify. 100 nanometers

Pharmanex Nanotechnology To increase intestinal uptake of poorly absorbed fat-soluble nutrients: Carotenoids (lycopene, alpha+beta-carotenes, zeaxanthin, astaxanthin) Coenzyme Q10 Pharmanex is leading the industry by using nanotechnology to improve the intestinal uptake of certain nutrients, which are typically difficult to absorb, such as coenzyme Q10 and carotenoids.

The Nanotechnology Difference Coenzyme Q10 and carotenoids are not easily dissolved in the intestine, because they are fat-soluble, and tend to clump together in big particles. We already know from our studies on g3 that dissolving these fat-soluble nutrient in lipids helps improve absorption. This is what we call Lipocarotenes. But we know now that we can improve upon this using nanotechnology. We actually perform a nano-encapsulation of individual molecules with a very special ring-shaped molecule, called cyclodextrin. This nano-encapsulated nutrient no longer tends to clump together. Instead it disperses well inside the intestine, and is much easier to absorb. It’s just like the ping-pong balls Joe showed you yesterday; they easily get into small spaces and disperse quickly. We have applied this type of nanotechnology to 2 new Pharmanex products: NanoCoQ10 and LifePak Nano. Small nano-particles are easily dispersed and absorbed

The Nanotechnology Difference 5-fold increase in absorption! This bioavailability study shows that human intestinal cells absorb over 5 times the amount of coQ10, when it’s present in the nano-form, compared to conventional chewable tablet or powder forms. That means that our 30 mg dosage in NanoCoQ10 is equivalent to about 150 mg doses of regular coQ10.

lifepak nano: CR-6 LipoNutrients New, broader-spectrum nano-carotenoid formula: alpha-carotene beta-carotene lycopene lutein zeaxanthin (new): Eye health benefits* astaxanthin (new): Inflammatory balance* plus LipoNutrients (proprietary process) Here are all the carotenoids in LifePak Nano. We also added 2 new carotenoids: zeaxanthin, which recently has been shown to improve eye health with lutein, and astaxanthin, which is helps promote a normal balance of pro- and anti-inflammatory factors in the body. Finally, we also include Liponutrients which also enhance absorption. Can you imagine what this would do to your antioxidant scanner scores? *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Lifepak nano: 60+ Antioxidants All 8 forms of natural vitamin E: 200 IU a-tocopherol + 75 mg g-toc. + 26 mg other toc. + tocotrienols Buffered vitamin C: 500 mg Selenium, Copper, Zinc, Manganese (for SOD, GPX) 11 Carotenoids, now with astaxanthin and zeaxanthin: as found in 5-10 fruits & vegetables per day 35 polyphenols: green tea (catechins), red wine (resveratrol), grape seed, krill, etc. Alpha-Lipoic Acid, Coenzyme Q10, N-Acetyl-L-Cysteine LifePak provides many different types of antioxidants to combat many different types of free radicals - this is how LifePak promotes your entire antioxidant defense network. It provides clinically-significant doses of your antioxidant vitamins, mineral cofactors, multiple sources of carotenoids and their isomers (11), 35 polyphenols, and novel antioxidants, such as alpha-lipoic acid. Highlighted in red are the nano-antioxidants, carotenoids and coq10.

Ongoing placebo-controlled clinical study lifepak® nano Study 60+ Antioxidants Ongoing placebo-controlled clinical study lifepak nano Better antioxidant response than LifePak! 57 subjects 20 week study LifePak Currently, we have a study ongoing to see how LifePak Nano with its over 60 antioxidants increases Biophotonic Scanner scores in 20 weeks. For reference, I show here the results of a previous scanner study on regular LifePak. You can see how in 6 weeks, regular LifePak (in dark blue) increases the scanner score by about 7,000 units compared to the placebo (in light blue). Now I am super-imposing the preliminary 4-week scanner increases we are seeing with LifePak Nano (click animation). Although LifePak regular and LifePak Nano have fairly similar levels of total carotenoids, we are seeing a 50% higher scanner response with LifePak Nano. This demonstrates the power of nanotechnology and Lipocarotene delivery! Placebo

lifepak nano: Omega-3 Lipids Delivers MarineOmega benefits: 600 mg EPA, 400 mg DHA Antarctic Krill oil Helps normalize omega 6/3 ratio:* helps restores normal inflammatory balance* promotes cardiovascular health* promotes healthy joints and cartilage* supports brain & nervous system* (read through), then: Notice the two-chamber packet; the omega-3 lipids are in the dark soft gel capsules, separated from the other capsules to guarantee maximum stability. *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Other lifepak nano Innovations New high g-tocopherol vitamin E blend synergistic antioxidant effects with alpha-tocopherol* helps restore normal inflammatory balance* New calcium & magnesium sources 100 % soluble and organic (GI tolerance) Red wine polyphenols resveratrol, proanthocyanidins and quercetin New 2-chamber packet design Improved protection *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

lifepak nano Health Benefits* Optimum supplementation for general well-being Effectively addresses all nutrient deficiencies Comprehensive cardiovascular benefits Complete bone nutrition Promotes healthy immune function Supports blood sugar metabolism Helps protect eye function Raises your antioxidant defense Protects against the normal symptoms of aging Promotes a healthy balance of pro- and anti-inflammatory signals (prostaglandins) in the body Excellent gastro-intestinal tolerance Because LifePak provides optimum supplementation, it has many more health benefits than typical multivitamins: It addresses (read…) *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The New Dimension! For All Adults (age 18-121) Proprietary Science Broadest Health Benefits LifePak Nano is the ultimate supplementation program for all adults. LifePak Nano is built on cutting-edge, proprietary science! LifePak Nano has by far the broadest health benefits of any Pharmanex product ever produced! With LifePak Nano, Pharmanex is entering into a new dimension of dietary supplements. It’s truly a monumental product! Please notice that all other LifePak’s will remain available. But how can anyone resist LifePak Nano?

Do you nano?

= gâc fruit + 3 superfruits = 3 years of Pharmanex research = 3 Pharmanex research labs Gâc fruit (Chinese Bitter Cucumber) Chinese Lycium (Wolfberry) Cili fruit Siberian Pineapple (Seabuckthorn)

Gâc - “Fruit From Heaven” Indigenous to Southern Asia Bangladesh, Burma, Cambodia, China, India, Japan, Laos, Malaysia, Philippines, Thailand, and Vietnam Traditionally used internally and externally Topical: wound healing Internally: eye health, and to promote growth in children Many people asked us . . .

Antioxidants in Gâc Pulp Extraordinarily rich in antioxidants, esp. lycopene: 70x more than tomatoes beta-carotene: 10x more than carrots Unique fatty acids → Lipocarotenes™ 40% improved bioavailability of carotenoids! Pulp (aril) Fruit flesh (mesocarp) Seeds

Gâc Fights Vitamin A Deficiency Vitamin A deficiency: Leading cause of blindness in the world In So. Asia, Gâc discovered as potent indigenous source of highly bioactive provitamin A (b-carotene) 10 years of research by Dr. Le Vuong, Univ. of California, Davis, Nutrition Department *Vuong LT et al., Am J Clin Nutr 2002;75:872-879.

Other Ingredients Siberian Pineapple (sea buckthorn, Hippophae rhamnoides) 2000-year history of traditional use in Siberia, Tibet, China and Europe rejuvenating tonic, for skin health, blood purifier Over 130 modern research studies: Cardiovascular health* Healthy liver function* Periodontal health* Eye health* Immunity* High in vitamins A,C, E, B-vitamins and minerals, and 190 other actives! *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Other Ingredients Chinese Lycium (Wolfberry; Lycium chinense) 2000 years TCM history in China Longevity, wellness, vision Cellular rejuvenation: protects DNA* antioxidant (SOD, GPX)* Immunity (polysaccharides)* Eye health: 40x more zeaxanthin than yellow corn! *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Other Ingredients Cili Fruit (Rosa roxburghii) China, esp. Guizhou mountains Cardiovascular and antioxidant benefits: ↓ oxLDL, ↑ SOD* Addresses symptoms of Aging* Unique Polyphenols Roxburghic Acids “King of C”: 60x more vitamin C than oranges! *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is Catalytically Active g3 activates SOD and Catalase the body's catalytic antioxidant system antioxidant protection inside the cell, where it is needed the most. SOD: Superoxide Dismutase most important antioxidant enzyme requires copper, zinc & manganese (LifePak) *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Vulnerable to Oxidation Lutein Lycopene Betacarotene Vitamin C Vitamin E

Internal Antioxidants SOD Catalase Vitamin E SOD CAT

- 303 studies

Clinical Study 34 Subjects consumed for 8 weeks: 6 fl oz g3 (maximum recommended intake) 6 fl oz Noni Juice (6x’s recommended dose) 6 fl oz Xango Juice (2x’s recommended dose) Measure antioxidants using BioPhotonic Scanner

Increased Antioxidant Scores 4x More than Xango or Noni #, * * 2,000 4,000 6,000 8,000 10,000 Week 0 Week 2 Week 4 Week 6 Week 8 Antioxidant Score Noni Xango g3 Small increase with xango and noni at week 8 could have been due to changes in baseline diet (no placebo in this study). Note that when expressed per maximum recommended usage, g3 (6 fl oz) is 8x more effective than Xango (3 fl oz) and 24x more effective than noni (1 fl oz), in terms of antioxidants. The 9500-unit increase with g3 in 8 weeks is about 50% higher than what we would have expected based on data from tablet or capsule forms. This confirms the higher bioavailability of Lipocarotenes, which was also shown by Dr. Vuong (40% better, AJCN study). *p<0.05 compared to wk 0 #p<0.05 compared to other juices

Proprietary Patent pending, 100%-juice formula First juice with Gâc worldwide

The Measurable Difference You have the 3 most powerful tools of the entire nutritional supplement industry worldwide: lifepak nano: The best multi-nutrient supplement. : The best functional fruit juice. BioPhotonic SCANNER: The best consumer test for antioxidant nutrition.

For More Information Presentations www.pharmanexusa.com My Office  Marketing Tools Product Resources www.pharmanexscanner.com Product Support E-Mail: productsupport@pharmanex.com Phone: 1-800-487-1000