Avian Influenza A(H5N1) and Risks to Human Health Technical Meeting on Highly Pathogenic Avian Influenza and Human H5N1 infection Rome 27 - 29 June 2007.

Slides:

Advertisements

Similar presentations

Dr S Aboobakar Regional Public Health Superintendent.

Advertisements

Regional Health Focus Rome | 27 – 29 June |1 | Health Focus WHO Regional Perspective FAO/ OIE/ WHO Technical Meeting on Highly Pathogenic Avian.

U.S. Pandemic Influenza Preparedness and Response: Planning and Activities “The pandemic influenza clock is ticking. We just don’t know what time it is.”

Communicable Disease Surveillance & Response WHO-WPRO Pandemic (H1N1) 2009 situation and response in the Western Pacific Region Takeshi Kasai Communicable.

FDA H5N1 Update: Classification of H5N1 Viruses and Development of Vaccine Reference Strains FDA H5N1 Update: Classification of H5N1 Viruses and Development.

Avian Influenza – The Bird Flu

Avian Influenza / Pandemic Influenza Neyla Gargouri Darwaza, M.D. Surveillance Department Directorate of Disease Control Ministry of Health, Jordan.

So Far Primarily an Avian Disease Considering geographic spread and lethality in birds – very little human disease Fear that the virus may develop the.

Avian influenza A simple introduction.

Mmmmm Mohamed M. B. Alnoor CHP400 COMMUNITY HEALTH PROGRAM-II Avian Influenza H5N1 Epidemiology & Control mmmmm.

Bird Flu.  Bird flu, also known as Avian Influenza, is a type A influenza virus. It is fatal to humans. Bird flu spreads between both wild and pet birds.

Andrew Pelletier, MD, MPH Maine Department of Health and Human Services June 26, 2006 Pandemic Influenza.

Nicole J. Cohen, MD, MSc Chicago Department of Public Health

Seasonal Influenza and Swine-Origin Influenza A (H1N1) Virus

SARS Timeline Nov 16 ‘02 Feb 11 ‘03 Feb 28 March 11 March 12 March 19 March 27 April 5 April 9 April 14 April 17 April 28 First cases Hong Kong WHO Sequence.

By Andrew Garaniel University of California, Irvine

ONE WORLD. ONE HEALTH Rockefeller University New York – 29 September 2004 "History of zoonotic avian influenza" By F.X. Meslin Co-ordinator, Strategy development.

Preparing for an Influenza Pandemic in Westminster Health and Community Services Overview and Scrutiny Committee 9 Oct 2006 Dr Margaret Guy Director of.

DR. JULIE LOUISE GERBERDING DIRECTOR CENTERS FOR DISEASE CONTROL AND PREVENTION CURRENT STATUS OF AVIAN INFLUENZA AND PANDEMIC THREAT PRESENTATION TO IOM,

Technical support provided by: Highly Pathogenic Avian Influenza Control Programme Threats and Problems of Bird Flu Market chain cleaning and disinfection.

Developing a vaccine and how a pandemic could occur.

Influenza Surveillance at IRID Immunization and Respiratory Infections Division Centre for Infectious Disease Prevention & Control Public Health Agency.

Novel Coronavirus and H7N9 Influenza Infections Situation update May 2013 Craig Roberts, PA-C, MS ACHA Emerging Public Health Threats & Emergency Response.

Progress Report Global Pandemic Preparedness Beijing Conference January 2006 Dr Margaret Chan Assistant Director-General Communicable Diseases Representative.

Pandemic Influenza. Guidance for Pandemic Influenza: Infection Control in Hospitals and Primary Care Settings UK Pandemic Influenza Contingency Plan Operational.

GAP Risk Assessment June Avian Influenza (Bird Flu) Three continents affected (Asia, Africa and Europe) Worrying situation in Indonesia, Egypt and.

Avian Flu. Simplified Bird flu timeline (HONG KONG) - 18 Hong Kong people infected by Avian influenza - Epidemic of bird flu in local poultry.

Surveillance Activities during Pandemic Phases Anne-Luise Winter APHEO-COMOH Workshop Toronto February 1, 2007.

Global H5N1 Epidemiology Status of Pandemic Preparedness 29 January 2007 Beijing Keiji Fukuda Global Influenza Programme.

Lessons from the European Experience with A(H1N1) 2009 Angus Nicoll CBE European Centre for Disease Prevention and Control 3 rd meeting of the National.

Responding to SARS John Watson Health Protection Agency Communicable Disease Surveillance Centre, London.

Planning for Pandemic Influenza Name Organization.

HHS Pandemic Influenza Preparedness Planning Julie Louise Gerberding, MD, MPH.

Dr. Zhen XU Branch of Respiratory Disease Prevention and Control Division for Disease Control and Emergency Response Chinese Center for Disease Control.

Avian Influenza "bird flu" Contagious disease of animals caused by viruses that normally infect only birds and pigs H5N1 can infect people (very rarely)

2008 Avian Flu 1. Avian influenza is an infection caused by (bird) influenza viruses naturally occurring among birds. Wild birds worldwide carry the viruses.

Protecting American Agriculture 1 Avian Influenza: Agricultural Perspectives & Interventions March 2006.

World Health Organization, Regional Office for The Western Pacific Regional Activities Report and Preparation for the Upcoming Influenza Seasons THE 3rd.

Preparing for a Influenza Pandemic in Utah Robert T. Rolfs, MD, MPH Utah Department of Health December 4, 2006.

Severe Acute Respiratory Syndrome (SARS) and Preparedness for Biological Emergencies 27 April 2004 Jeffrey S. Duchin, M.D. Chief, Communicable Disease.

Food and Drug Administration

US Situation Update and CDC International Response H1N1 Pandemic US Situation Update and CDC International Response Peter Nsubuga, MD, MPH On behalf of.

SARS. What is SARS? Severe Acute Respiratory Syndrome Respiratory illness Asia, North America, and Europe Previously unrecognized coronavirus.

1 Novel Influenza A H1N1 Outbreak: The Florida Response Epidemiology Perspective: Situation Update.

© 2005 Prentice Hall Inc. / A Pearson Education Company / Upper Saddle River, New Jersey “Bird flu”  Caused by avian influenza virus (AIV)  Endemic.

Pandemic Influenza: What Is It and Why Should We Care? Dr. Judith A. Monroe, MD State Health Commissioner.

OBJECTIVES Pandemic Influenza Then and Now Public Health Pandemic Influenza Planning –What to expect –What not to expect Individual/Employee Pandemic.

The Vermont Department of Health Overview of Pandemic Influenza Regional Pandemic Planning Summits 2006 Guidance Support Prevention Protection.

Communicable Disease Surveillance and Response, WHO Avian Influenza Credit: WHO Viet Nam.

Pandemic Preparedness Rome | June |1 | Pandemic Preparedness FAO/ OIE/ WHO Technical Meeting on Highly Pathogenic Avian Influenza, June,

1 |1 | Situation Update Influenza A (H1N1), 26 May 09.

Conclusions 3 rd Meeting of National Influenza Centres in the Western Pacific and South East Asia Regions 18 – 20 August 2009 Beijing, China.

Wrap-up Day 2. Plenary Four: Pandemic and avian influenza updates Pandemic H1N1 – Origin of pandemic H1N1 virus – Genetically and antigenically homogenous.

Pandemic Vaccines Current and Future Issues 30 January 2007 Beijing Keiji Fukuda Global Influenza Programme.

It’s Just Not the Flu Anymore Rick Hong, MD Associate Chairman CCHS EMC Medical Director, PHPS.

The Vermont Department of Health Update on Pandemic Threat Cort Lohff, MD, MPH State Epidemiologist Guidance Support Prevention Protection.

The bird flu 刘真北京师范大学生命科学学院

Avian Influenza - The Human Health Perspective Dr. Andrew Larder FRCPC.

Avian Influenza H5N1 The Next Pandemic? May 9, 2006.

Agilent Restricted Influenza H1N1 A (Swine Influenza) Information for Agilent’s Employees.

Text WHO Regional Office for Europe Long wait for vaccine Influenza epidemic, New York, Times photograph Influenza Pandemic Preparedness Porto, October.

Preparing for Pandemic Flu Algean Garner II, Psy.D. Director, Health and Human Services Village of Hoffman Estates.

Chapter 11: Nursing in Pandemics and Emergency Preparedness.

AHI + Humanitarian Action

Avian Influenza A (H5N1) “Bird Flu”

Animal-Human Interface

World Health Organization

وبائية أنفلونزا الطيور والإجراءات المتخذة لمواجهة الوباء العالمي

The Role of NICs in Influenza Surveillance

Avian Influenza Prevention and Control from an OIE Perspective

Presentation transcript:

Avian Influenza A(H5N1) and Risks to Human Health Technical Meeting on Highly Pathogenic Avian Influenza and Human H5N1 infection Rome June 2007 Keiji Fukuda Global Influenza Programme World Health Organization

Major Public Health Threats of Influenza Seasonal –Greatest health impact over time Avian influenza H5N1 virus –Most often direct/indirect zoonotic infection from infected birds –Infrequently direct contact with an infected person –Other exposures not clearly established Emergence of a human pandemic strain –H5N1 most concern due to spread & pathogenicity –Another novel subtype possible

Laboratory-confirmed human H5N1 cases, since cases 190 deaths

Hong Kong/156/97 Vietnam/JP14/05 ck/Cambodia/013LC1b/05 Vietnam/1194/04 Vietnam/1203/04 Vietnam/HN30408/05 Thailand/16/04 Vietnam/JPHN30321/05 Clade 1 Hong Kong/213/03 Indonesia/CDC523/06 Indonesia/CDC699/06 Indonesia/CDC326/06 Indonesia/5/05 Indonesia/CDC184/05 Indonesia/7/05 dk/KulonProgoBBVET9/04 ck/Indonesia/CDC25/05 Indonesia/6/05 ck/Brebes/BBVET2/05 Indonesia/CDC594/06* ck/Dairi/BPPVI/05 Clade 2.1 ck/Yunnan/374/04 ck/Yunnan/115/04 ck/Yunnan/493/05 ck/Yunnan/447/05 dk/Guangxi/13/04 ck/Guangxi/12/04 whooping swan/Mongolia/244/05 bar headed gs/Qinghai/1A/05 * Turkey/65596/06 Turkey/15/06 Iraq/207NAMRU3/06 ck/Nigeria/641/06 mld/Italy/332/06 turkey/Turkey/1/05 Egypt/2782NAMRU3/06 Djibouti/5691NAMRU3/06 ck/Nigeria42/06 migratory dk/Jiangxi/2136/05 gs/Kazakhstan/464/05 ck/Krasnodar/01/06 Azerbaijan/011162/06 swan/Iran/754/06 Clade 2.2 dk/Laos3295/06 Anhui/1/05 Anhui/2/05 Japanese white-eye/Hong Kong/1038/06 ck/Malaysia935/06 Vietnam/30850/05 Guangxi/1/05 dk/Hunan/15/04 qa/Guangxi/575/05 dk/Vietnam/Ncvdcdc95/05 Clade 2.3 migratory dk/Jiangxi/1653/05 gs/Guangdong/1/96 * Karo cluster Indonesia/CDC625/06* Phylogenetic tree based on H5 HA Strains in yellow: vaccine strains Vietnam Thailand Cambodia Indonesia Middle east Europe Africa China Laos

Characteristics of confirmed H5N1 human cases M:F = 0:9 All age groups affected –Higher incidence in age group < 40 years Case fatality ~ 63% Median duration of illness –Onset - hospitalization 4 days –Onset - death 9 days Clinical features –Severe cases feature pneumonia, ARDS –Asymptomatic infection appears rare

Risk factors and exposures H5N1 in humans Primary known exposures associated with infected birds –Unprotected handling –Sharing living areas Route of virus entry into humans uncertain Risk appears highest in countries with infected birds where –Human contact with poultry is frequent –Animal disease detection and/or control is a challenge No identifiable exposures for some cases

Human-to-Human H5N1 Transmission Epidemiological diagnosis of exclusion –Plausible epidemiological link –No other probable exposures –Viruses consistent –" Limited human-to-human transmission cannot be ruled out" Typically associated with very close prolonged contact between susceptible and severely ill person No occurrence of human-to-human transmission capable of sustained community outbreaks

Prevention and treatment of human H5N1 infection One H5N1 vaccine licensed but not yet field tested –Others applications in submission Optimal antiviral treatment regimen is yet unknown –Early oseltamivir treatment might reduce H5N1-associated mortality Antiviral resistance requires monitoring Limited evaluation of other therapies –E.g, immuno-modulators, convalescent sera

WHO Strategic Action Plan Pandemic Influenza Strengthen Early Warning system Reduce Human Exposure to H5N1 virus Intensify Rapid Containment operations Build Capacity to cope with pandemic Coordinate Global Scientific Research and Vaccine Development

WHO Global Influenza Surveillance Network

Important Current Activities l Implementation of IHR l Continuing development of framework to facilitate sharing of influenza viruses and related benefits l Maintain rapid global threat assessment & response l Clearer operating terms & conditions l Greater access of developing countries to benefits l Short to long term solutions for improving pandemic & H5 vaccine situation l Stockpiles l Global Pandemic Influenza Vaccine Action Plan

H5N1 Cluster Graph Cluster –Two or more epidemiologically linked cases –At least one has a lab-confirmed H5N1 infection –Inclusion of fatal probable cases Unexplained deaths linked epidemiologically to a confirmed case (probable case) Cases in clusters