Progressione centri attivati vs pz. trattati

Time delay (median min) Italy All centres Onset to treating hospital/door time Door to imaging study time Door to treatment/needle time Onset to treatment/needle time Time logistics

VariablesItalyAll centres Age6970 Male56%54% Female44%46% NIHSS Median NIHSS 0-732%34% NIHSS %33% NIHSS >1534%33% Current smoker17%16% Previous smoker14%11% Atrial fibrillation18%21% Congestive heart failiure7%8% Systolic Diastolic Demographic and baseline data

Clinical outcome at 3 months mRS 0-2Recovered patients Proportion recovered Lower Confidenc e Limit Upper Confidence Limit Italy971/159461,358,963,7 All centers3033/528658,35759,7 mRS 0-1 Italy781/159449,346,951,8 All centers2262/528643,542,244,9 MortalityDead within 3 months Proportion Dead Lower Confidenc e Limit Upper Confidence Limit Italy174/169410,38,911,8 All centers760/611012,411,613,3

Symptomatic intra-cranial hemorrhage SICH definition SICH patients Proportion SICH Lower Confidence Limit Upper Confidence Limit SITS-MOST Italy36/18961,91,42,6 All centers90/61231,51,21,8 ECASS Italy74/182843,25,1 All centers263/524254,55,6 NINDS Italy123/18286,75,78 All centers367/524276,37,7

Clinical outcome at 3-months (bNIHSS≥10; median 16) mRS 0-2N° of patients ProportionLower Confidenc e Limit Upper Confidenc e Limit Italy335/83440,537,243,8 All centers1055/276238,83740,6 mRS 0-1 Italy233/83428,125,231,3 All centers713/276226,224,627,9 MortalityDead within 3 months Proportion Dead Lower Confidenc e Limit Upper Confidenc e Limit Italy149/90716,414,219 All centers622/329018,917,620,3

Quanti pazienti dovremmo trattare? ~50% non trattabili ≤ 4.5 h 50% ~ ~ ≤ 3 h 30% ≤ 4.5 h 50% ~ ~ ~ ~ Range ~ – pz./anno ≤ 3 h 30% ~ Trattabili con tPA per RCP ~ 25% ~ Nuovi casi Totale Recidive Incidenza Ictus ischemico in Italia 30% / = 14.5%