Why you need this App Sean Ekins 1, Alex M. Clark 2 1 Collaborations in Chemistry, 5616 Hilltop Needmore Road, Fuquay Varina, NC 27526, U.S.A. 2 Molecular Materials Informatics, 1900 St. Jacques #302, Montreal, Quebec, Canada H3J 2S1.

Why you need this App What if you need to find out about the latest news on a neglected or rare disease fast What if you are tired of the status quo and want to do rare and neglected disease research differently What if you want to share your ideas with the world Where do you go? Look no further – you are about to find out the solution

1. Intro What is a rare disease?

How do parents or patients find out about a disease?

Commonalities Both neglected and rare disease research have a problem Too many diseases without cures Too little money to go around Too little collaboration Too many people dying and suffering Long term cost to mankind is immense

How could scientists collaborate on rare or neglected diseases?

Enter – Open Drug Discovery Teams – the first free mobile app for rare and neglected disease information

2. Why not create an app? Can we connect researchers and patients? Can we create Open Drug Discovery Teams How do we bring information on diseases to the people that need it Can we centralize the data that matters? Bring social media into rare diseases

3. What influenced design? Simple user friendly design concept Flipping through topics, big buttons, easy to see on phone and app Crowdsourcing – use feedback to vote on topics Why is there no Flipboard for Science?

9 Panels includes one on ODDT information Can use multiple Twitter accounts Here is my icon Stats summary About App

4. Topics We picked topics we had an interest in scientifically We picked topics suggested by parents of children with rare diseases We picked topics we felt could benefit from open sharing of data We picked topics that needed a new way of thinking

Disease Topics Sanfilippo Syndrome Giant Axonal Neuropathy Tuberculosis Malaria Chagas Disease Leishmaniasis Huntingtons Disease HIV/AIDS H5N1 flu

Other Topics Drug Repurposing – News on FDA approved drugs that can be used for diseases other than those they were originally intended for – Faster way to cure diseases? Green Chemistry – Make chemical synthesis better for the environment – Use safer chemicals to find cures for diseases

5. How to use the app Use it to publish links to your blogs on the topic Publish your chemistry, Structure activity data that could help others Use it to raise awareness of a new paper Parents / researchers can find out about the disease – what is current, what has published Use it to collaborate openly – an open labnotebook You can curate the data – vote on what matters to you Share the important findings Use it for inspiration that crosses diseases and topics Get rare and neglected disease researchers to use green chemistry.

6. What can it do? Collects Twitter feeds on hashtags for topics Collects Google Alerts on topics Allows you to see tweets of molecules and structure activity data If you contribute to a topic you are visible in the app It can track your contributions to topics All of the above happens in one App

Click here to endorse or disapprove Click here to follow hyperlink Look at a topic and see the content

Endorse or disapprove content

Look at endorsed content

See molecules in the app Click on image to open it Ranked content

Interact with other Apps

Find Structure activity relationship data that is published for diseases

Stats summary

7. Future The App becomes a “notebook” for science Integrate other data sources PubMed, Google Scholar etc Add annotation around diseases Becomes a database of chemistry and biology data around the diseases that is open Link to tools that enable drug discovery by anyone

8. Why we need funding

9. Vision 4 future

10. Acknowledgments Antony Williams, RSC