«Technological device for industrial solid-phase synthesis of peptides» “SynChro” Ltd. «Biomac-Innovation» General director “SynCho” Ltd. Dr. Arkavy Igor , Moscow, Klara Zetkin str.4, Phone/fax:

“SynChro” Ltd. Founded in 2004 Team is 8 peoples: 3 scientists 2 engineers 1 technician 1 economist 1 manager

“SynChro” Ltd. Founders of “SynChro” Ltd. are: Authors of project from the Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS, (Pushchino Moscow region) «Biomac-Innovation» “SynChro” Ltd. legal form is a small enterprise.

Synthesis of peptides The automatic solid-phase method for peptides synthesis in automated synthesizers : is the most perspective for manufacturing of peptides; is used by the leading manufacturers of substances and drugs all around the world; is complied with GMP requirements.

Advantages of continuous-flow synthesizer Reduction in price of synthesized product by 30% due to: decrease in solvent consumption by more than ten times; decrease in reagent consumption by more than 2-4 times.

Laboratory unit The pilot batch of laboratory units for automatic solid- phase peptides synthesis was released in 1999, passed all tests and is using in a work till now days.

Key consumers Peptides substances manufacturers for pharmaceutical industry Solid-phase synthesis of peptides with following chromatographic purification Manufacturers of immunobiological drugs Purification of drug substances produced using another methods Use of accessories (column- reactors, taps, pumps) in different technological processes. Research and development organizations and universities Utilization of analytical synthesizer and accessories Rendering of services for solid- phase synthesis and purification of analytical quantities of peptides

Russian analogues Positioning on the market Foreign industrial synthesizers of peptides with batch reactors Price: USD Preparative peptides synthesizer with continuous-flow reactor (model) Estimated price is USD

Basic segments of the world market SegmentQuantity of potential customers Quantity of peptides produced (kg) Annually costs on acquisition of equipment, (million USD) Industrial synthesizers Laboratory synthesizers Organic compounds’ synthesizers –210 Scientific equipment8 000–300 Rendering of preparative solid-phase synthesis services Purification of analytical quantity of peptides Total:

Basic segments of the market in Russia SegmentQuantity of potential customers Quantity of peptides produced (kg) Annually costs on acquisition of equipment, (million USD) Industrial synthesizers ,5 Laboratory synthesizers ,1 Organic compounds’ synthesizers 2 300–9,5 Scientific equipment550–10 Rendering of preparative solid-phase synthesis services ,96 Purification of analytical quantity of peptides ,54 Total: ,6

The present stage of the project Present stageRealization of research and development work (R & D) Present financingThe Foundation for assistance to Small Innovative Enterprises (FASIE) – financing of the first year of research and development work “Biomac-Innovations” (business-incubation of the project) Perspective financing The negotiations are carrying out with a Venture fund about financing the manufacture and creation of technical basis for industrial synthesis and purification peptides custom services. Structural organization of the project The realization of the project is carried out by special founded company ”SynChro” Ltd. Intellectual propertyThe patents for laboratory synthesizer are present. It is planned to take out patents for useful model and key components of the industrial column-reactor synthesizer till May 2005.

The present stage and future outlook for project financing Required volume of investments for 3 years $ Real financing Perspective financing $ FASIE Fund (1-st year of R&D) $ FASIE Fund (2-nd and 3-rd years of R&D) $ Selling of unexceptional licenses $ Commercial credit From German Bank $ Other Russian investments $ Subventions from Land Brandenburg

The structure of expenditures $ $ Licensing Certification Marketing Promotion $ – 3 year $ – 2 year $ – 1 year $ R&D $ – 3 year $ – 2 year $ – 1 year $ Application to production $ Peptides purification and technical services $ – 2-3 year

Suggested business-plan Manufacturing and selling of industrial synthesizers Manufacturing and selling of laboratory synthesizers Rendering services for industrial peptides synthesis and puriffication Rendering services for synthesis and purification of peptides for laboratories Rendering services for purification of olypeptides obtained by another methods (interferon, insulin, oxytocin, etc.) Manufacturing and selling of accessories, having separate application (columns, pumps, etc.) Technologies transfer

Next step in project realization There are certain problems with manufacturing and assembling some parts of device in Russia SynChro Ltd. ZABBrainshell Biomac- Innovation Consulting Team Biotechnopark in Berlin/Bran- denburg Technological partner in Germany Russian marketGerman market Joint manufacturing

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