THE BODY’S DEFENSE CHAPTER 43

Figure 43.4 The human lymphatic system

Figure 43.0 Specialized lymphocytes attacking a cancer cell

Figure 43.2 First-line respiratory defenses. Inside the lining of the trachea. Yellow cells are ciliated. Orange cells secrete mucus.

Figure 43.1 An overview of the body's defenses

NONSPECIFIC DEFENSE Skin Mucus Secretions

CELLS: Nonspecific Neutrophils - engulf microbes (phagocytosis); self-destruct after destroy microbes Monocytes - develop into macrophages which can migrate into tissues and engulf microbes

Figure 43.x1 Anabaena (a blue-green algae that makes a toxin, which causes cell death) phagocytosed by a human neutrophil Anabaena

Figure 43.3x Macrophage

Figure 43.3 Phagocytosis by a macrophage Bacilli Pseudopodia of macrophage

Esinophils - destroy parasitic worms Natural killer cells - destroy viral-infected cells

INFLAMMATORY RESPONSE Arterioles dilate to increase blood flow to damaged area Increased WBC in damaged area Histamine and prostaglandins released to dilate arterioles Chemokines - chemical signals for cells to follow

Figure 43.5 A simplified view of the inflammatory response

SPECIFIC DEFENSE Response is to a specific microbe Antigen - foreign molecule Antibody - proteins made to attach to specific antigens

CELLS:Specific B lymphocytes - develop in bone marrow; differentiate into plasma cells which secrete antibodies; also make memory cells T lymphocytes - develop in thymus; activate B cells and other WBC; also make memory cells

Figure 43.8 The development of lymphocytes

Figure 43.8x B lymphocyte

Figure 43.6 Clonal selection

Primary immune response - first exposure; days; make antibodies Secondary immune response - already been exposed; days; memory cells make antibodies quickly

Figure 43.7 Immunological memory

TOLERANCE FOR SELF Major histocompatibility complex (MHC) on cells –Class I MHC on all nucleated cells –Class II MHC on macrophages, B cells and activated T cells –Biochemical fingerprint –As your cells develop, if fingerprint is wrong then cell death occurs

–MHC molecules cradle foreign antigens. They present the antigen to other cells. MHC I presents antigens to Cytotoxic T cells which kill bad cells MHC II presents antigens to Helper T cells –Cells that present antigens are called antigen presenting cells. These include macrophages and B cells.

Figure 43.9 The interaction of T cells with MHC molecules

HUMORAL VS. CELL MEDIATED IMMUNITY Humoral - B cells activated by free antigens (free bacteria, toxins, viruses) Cell mediated - depends on T cells; active against cells infected with viruses and bacteria; as well as free fungi, protozoa, and worms

Figure 43.9 The interaction of T cells with MHC molecules

Figure An overview of the immune responses (Layer 4)

T Helper Cells Antigen presenting cells (APC) include B cells and macrophages Present antigen on class II MHC T helper cell binds to MHC II with antigen CD4 on T h cell holds APC cell and T h cell together

T h then activates T cytotoxic cells T cytotoxic cells can then lyse infected cells

Figure The central role of helper T cells: a closer look

Figure 43.12a The functioning of cytotoxic T cells

Figure 43.12b A cytotoxic T cell has lysed a cancer cell

ANTIBODY PRODUCTION T-dependent antigens - B cell must be activated by T h cell; most protein antigens T-independent antigens - directly stimulate B cells to make antibodies; mostly polysaccharide antigens

Figure Humoral response to a T-dependent antigen (Layer 3)

ANITBODY MEDIATED DISPOSAL OF ANITGEN Opsonization - many antibodies bound to antigen enhance macrophage phagocytosis Agglutination - antibodies attach to many antigens; clumping them together to enhance phagocytosis

Figure Effector mechanisms of humoral immunity

ACTIVE IMMUNITY Depends on response of infected person’s immune system May be artificially induced by vaccinations

Figure 43.x2 Vaccination

PASSIVE IMMUNITY Antibodies transferred from one individual to another Some antibodies can move across placenta to baby in pregnant women Nursing

HEALTH AND DISEASE Review ABO blood types and Rh MHC causes tissue and organ rejections In bone marrow transplants, donated marrow (with WBC) will react against recipient

Allergies - overproduction of certain antibodies causes histamine to be released –Runny nose –Teary eyes –Smooth muscle contractions = hard breathing

Figure 43.x4 Alternaria spores, a cause of allergies in humans

Anaphylactic shock - life- threatening reaction; abrupt dilation of arteries causes serious drop in blood pressure Autoimmune diseases - attack own body –Lupus, rheumatoid arthritis, MS Immunodeficiency Diseases –Severe combined immunodeficiency (SCID), Hodgkin’s

Figure 43.x3 X-ray of hands with arthritis

AIDS - acquired immunodeficiency syndrome –Two major strain: HIV I and HIV II –Bind to CD4 and therefore T h cells –Insert its RNA and reverse transcriptase makes viral DNA that is inserted into host’s DNA

–Exists as provirus so antibodies can’t get rid of it easily –Mutates often –May cause T h cell death –HIV positive = presence of HIV antibodies

Figure A T cell infected with HIV

Figure 43.19x1 HIV on a lymphocyte, detail

Figure The stages of HIV infection

Figure 43.x5 AIDS posters