ANTIMUTAGENS in food. FOOD Foods are comlex mixtures containing both carcinogenic and anticarcinogenic substances. It is our choice – HEALTHY x NOT HEALTHY.

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Presentation transcript:

ANTIMUTAGENS in food

FOOD Foods are comlex mixtures containing both carcinogenic and anticarcinogenic substances. It is our choice – HEALTHY x NOT HEALTHY Prevention against cancer - ANTIMUTAGENS

Carcinogenesis Carcinogenesis: TWO STAGE PROCESs a) Initiation b) Promotion Inhibitors of mutagenesis = inhibitors of carcinegenesis

Antimutagens REDUCE NUMBER OF MUTATIONS Clasification: a) Desmutagens – they inactivate mutagens b) Bioantimutagens – reduce effect of mutagens Antioxidants „catch free radicals“

ASCORBIC ACID Water soluble The strongest antioxidant in body Cofactor of many enzymes dopamin - andrenalin

VITAMIN E It contains 8 substances (90%  -tokoferol). Fat soluble – inhibition of oxidation of unsaturated fatty acids. The richest natural source- plant oil

 - Karotene Lipid soluble pigment Enzymatically hydrolyzed – Vitamin A Antioxidant – fat stores and lipid membranes Treatment of some genetic diseases

SULFIDES Diallyl sulfide, diallyl disulfide – garlic React with nirosoamines Reduce level of LDL cholesterol and triacylgycerols

Glutathion Tripeptide Reducing agent, soluble in cellular plasmas Defence against toxic compounds (aflatoxin….)

Selenium Toxic x antimutagens, antioxidant Mechanism not clearly defined, depends on concetration PRECISE (Prevention of Cancer through Intervation with Selenium)

FLAVONOIDS Large group of substances Antioxidants, antimutagens, regulation of cholesterol

CATECHINS Up to 30% weight of dry tea 1. green tea, 2. white tea, 3. black tea The effect depends on preparation

What have I forgotten..? I know, that there many other antimutagens I haven´t talked about. Magnesium, Unsaturated fatty acids, glukosinates …etc. I hope they will excuse me..;-)

+ AND THAT IS ALL THANK YOU FOR YOUR ATTENTION …