Cysteine
SMELLY STUFF
Organic compounds having SH or Sulfhydryl functional group with strong and disagreeable odors. “ Also called mercaptans “ Derivatives of hydrogen sulfide.
In 1834, W. C. Zeise discovered THIOLS. ZEISE named THIOLS as MERCAPTANS because they readily react with mercury to form an insoluble salt.mercury The term MERCAPTAN comes from the Latin mercurius captans, meaning 'laying hold of mercury,' because the –SH group binds tightly to the element mercury. Latinmercury
CH 3 – SH methanethiol CH 3 CH 2 – SH ethanethiol methyl mercaptan IUPAC IUPAC COMMON COMMON IUPAC IUPAC COMMON COMMON ethyl mercaptan
dibutylaminotriazinethiol
Glutathione
2-amino-5-{[2-[(carboxymethyl)amino]-1-(mercaptomethyl)-2-oxoethyl]amino}-5-oxopentanoic acid
CH 3 CH 2 CH 2 – SH propanethiol
CH 2 ═ CH – CH 2 – SH 2 – propene – 1 – thiol CH 2 ═ CH – S – CH ═ CH 2 Divinyl sulfide
CH 3 – CH – CH 2 – CH 2 – SH CH 3 3 – methyl – 1 – butanethiol C ═ C H H CH 2 – SH 3 HC Trans – 2 – butene – 1 – thiol
THIOLS tend to be a clear liquid or white crystalline form. Characteristic of other sulfur-containing compounds, THIOLS have a stench that smells similar to rotten eggs. The odor of THIOLS is often strong and repulsive, particularly for those of low molecular weight. THIOLS show little association by hydrogen bonding.hydrogen bonding They have lower boiling pointsboiling points Less soluble in water and other polar solvents than alcohols of similar molecular weight.solublepolar solvents
When a thiol group is a substituent on an ALKANE, there are several ways of naming the resulting THIOL: The preferred method (used by the IUPAC) is to add the suffix -thiol to the name of the alkane. The common name is obtained by writing the alkyl group name followed by the word mercaptan.
CH 3 – SH CH 3 – CH 2 – SH CH 3 – CH 2 – CH 2 – SH
CH 3 – CH 2 – C – CH 2 – CH 2 – SH OH CH 3
SH CH 2 ═ CH – CH 2 – CH 2 – SH
SH CH 2 ═ CH – C – C ≡ CH SH NO2
SH OH
Thiol + Thiol Disulfide + Water (O) Pt/Ni CH 3 – CH 2 – SH + HS – 2 HC – CH CH 3 CH 2 – S – S – 2 HCCH 3 + H2O (O)(O) Pt/Ni
SH + HS – CH3 --- (O) Pt/Ni S – S – CH 3 H2OH2O
Organic compounds containing – S – S – functional group.
CH 3 – CH 2 – CH 2 – S – S – CH 2 – CH 3 CH 3 – CH – S – S – HC – CH 3 CH 3
SS SSNO 2
Disulfides + Hydrogen → 2 Thiols Pt/Ni SS + H → Pt/Ni SHSH H – H 2
CH 3 – CH – S – S – HC – CH 3 CH 3 + H → Pt/Ni H – H HS – HC – CH 3 CH 3 2 SS + H → Pt/Ni H – H SHSH + CH 3 SH
Sulfur analogs of ETHER containing the – S – functional group and they are name by using the word SULFIDE to show the presence of the - S – group.
CH 3 – CH 2 – CH 2 – S – CH 2 – CH 3 S(CH 2 ) 3 – CH 3
S(CH 2 ) 5 – CH 3 S