VUOS COMPANY PROFILE PARTNER FOR COOPERATION

2 22VUOS – PARTNER FOR COOPERATION Where you can find us

3 33 VUOS – PARTNER FOR COOPERATION VUOS ownership AGROFERT HOLDING, a.s. SYNTHESIA, a.s. VUOS, a.s. 100%

4 44 VUOS – PARTNER FOR COOPERATION History

5 55 VUOS – PARTNER FOR COOPERATION VUOS main businesses 2. Toxicology and Analytics 1. R&D and Production of Fine Chemicals EmployeesSales in %

6 6 The Certificates of VUOS ISO 9001:2008 Certificates of Good Laboratory Practice Certificate of Accreditation for Certification of Products No. 229/2002 (EN 45011:1998) Certificate of Accreditation No. 230/2002 Testing Laboratory No (EN ISO/IEC 17025:2005) Certificate on Compliance with Principles of Good Manufacturing Practice in laboratory 6 VUOS – PARTNER FOR COOPERATION

7 77 Strong Points Education structure of employees VUOS is located in area of long-lasting chemical tradition and complete infrastructure Cooperation with University of Pardubice

8 88 VUOS – PARTNER FOR COOPERATION R&D, up scaling Pharmaceutical intermediates Intermediates for microelectronics Custom syntheses of chemical specialities Dyes and pigments for special application

9 9 R&D, up scaling 9 VUOS – PARTNER FOR COOPERATION Wide range of quantities Grams – in laboratory Kilograms – in kilolab unit Metric tons – in VUOS production plant Hundreds of MT –

10 VUOS ’s key chemistry VUOS ’s key technology 10 VUOS – PARTNER FOR COOPERATION Adamantane derivatives N-Heterocycles API Building Blocks Phosgenation Hydrogenation

11 VUOS – PARTNER FOR COOPERATION VUOS ’s technology/manufacture expertise includes: acetylation aldolisation amidation alkylation amination amoxidation alkali fusion arylhydrazines syntheses azocoupling benzoylation chiral synthesis chlorination chlorosulfonation cyclisation claisen condensation decarboxylation dehydrohalogenation diazotisation elimination esterification Friedel-Crafts reaction heterocyclic synthesis hydrolysis reactions neutralisation nitration nitriles syntheses oxidation – catalytic/chemical oxidation in liquid phase rearrangement reduction with hydrazine and sodium borohydride sulfonation

12 VUOS – PARTNER FOR COOPERATION Kilolab Unit 2x reactors, 250 and 650 l 2x High performance rectification columns Laboratory phosgenation units from 1 to 30 litres Phosgenation

13 VUOS – PARTNER FOR COOPERATION Kilolab Unit 3x autoclaves 100 l each, 60, 120 and 130 bar, up to 200 ˚C, Hastelloy C clad 1x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad 1x autoclave 700 l, 100 bar, 200 ˚C, stainless steel 1x autoclave l, 10 bar, 140 ˚C, stainless steel many autoclaves up to 10 l Hydrogenation

14 VUOS – PARTNER FOR COOPERATION Kilolab Unit 1 x glass reactor 50 l cooled down to – 80 ˚C 1x glasslined reactor for NaH reactions (250 l) 3x glass reactors 100l for RLi, Grignard reactions Low temperature, RLi, RMgX, NaH

15 VUOS – PARTNER FOR COOPERATION Kilolab Unit 20x glass reactors, 100 l each 6x glass lined reactors (200–1 500 l) 2x evaporators 50 l / h 4x stainless steel reactors (300–1 500 l) sufficient filtration and distillation capacity Multipurpose chemistry

16 45x glass lined reactors, total vol l (500–5 000 l) 13x stainless steel reactors, total vol l (1 000–3,000 l) 8x High performance rectification columns sufficient filtration capacity (nutsches, centrifuges) computer controlled Production Equipment 16 VUOS – PARTNER FOR COOPERATION Production Unit

17 VUOS – PARTNER FOR COOPERATION Toxicology, Ecology and Analytics

18 VUOS – PARTNER FOR COOPERATION REAC H and other legislative provisions Complete Offer of Services by VUOS CONSULTING TESTING – Physico – chemical tests – Toxicological tests – Ecotoxicological tests EXPERT WORKS REGISTRATION

19 VUOS – PARTNER FOR COOPERATION Analytical techniques: NMR Spectroscopy Mass Spectrometry (LC/GC-MS) ICP-AES IR Spectroscopy Chromatography (HPLC, GC) UV-Vis Toxicology, Ecology and Analytics

20 VUOS – PARTNER FOR COOPERATION Toxicology, Ecology and Analytics Toxicology: In vivo and in vitro testing according to the OECD or EU methods: Acute toxicity test Skin and eye irritation Sensibilisation Repeated dose tests Reproduction toxicity tests Carcinogenicity Mutagenicity

21 VUOS – PARTNER FOR COOPERATION Toxicology, Ecology and Analytics Ecotoxicological testing: In vivo and in vitro testing according to the OECD or EU methods: Aquatic toxicity Biotic degradation – Ready biodegradability Inherent biodegradability Abiotic degradation

22 VUOS – PARTNER FOR COOPERATION Contacts General Manager: Dr. Karel Novák Phone: , fax: Sales Manager: Miloš Jesenský,Ph.D. Phone: , fax: R&D: Alois Koloničný, Ph.D. Phone: , fax: Toxicology and Analytics: Viktor Mejstřík, Ph.D. Phone: , fax: Process Engineering: Luboš Víšek Phone: , fax:

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