VUOS PARTNER FOR COOPERATION 2 Where you can find us

VUOS PARTNER FOR COOPERATION 3 VUOS ownership AGROFERT HOLDING,a.s.. SYNTHESIA, a.s. VÝZKUMNÝ ÚSTAV ORGANICKÝCH SYNTÉZ a.s. (VUOS 100%

VUOS PARTNER FOR COOPERATION 4 History Foundation of Research Laboratories Voucher Privatisation New name – VUOS Affiliation of Synthesia´s R&D 100% daughter company of Synthesia a.s.

VUOS PARTNER FOR COOPERATION 5 VUOS main businesses 1.R&D and Production of Fine Chemicals 2.Toxicology and Analytics EmployeesSales in %

VUOS PARTNER FOR COOPERATION 6 The Certificates of VUOS ISO 9001:2008 Certificates of Good Laboratory Practice Certificate of Accreditation for Certification of Products No. 229/2002 (EN 45011:1998) Certificate of Accreditation No. 230/2002 Testing Laboratory No (EN ISO/IEC 17025:2005) Certificate on Compliance with Principles of Good Manufacturing Practice in laboratory

VUOS PARTNER FOR COOPERATION 7 Education structure of employees VUOS is located in area of long-lasting. chemical tradition with complete infrastructure Cooperation with University of Pardubice Strong Points

VUOS PARTNER FOR COOPERATION 8 R&D, up scaling pharmaceutical intermediates intermediates for microelectronics custom syntheses of chemical specialities dyes and pigments for special application

VUOS PARTNER FOR COOPERATION 9 R&D, up scaling Wide range of quantities Grams – in laboratory Kilograms – in kilolab unit Metric tons – in VUOS production plant Hundreds of MT –

VUOS PARTNER FOR COOPERATION 10 VUOS's key chemistry VUOS's key technology Adamantane derivates N-Heterocycles Hydrogenation Phosgenation API Building Blocks

VUOS PARTNER FOR COOPERATION 11 VUOS's technology/manufacture expertise includes: acetylation aldolisation amidation alkylation amination amoxidation alkali fusion arylhydrazines syntheses azocoupling benzoylation chiral synthesis chlorination chlorosulfonation cyclisation Claisen condensation decarboxylation dehydrohalogenation diazotisation elimination esterification Friedel-Crafts reaction heterocyclic synthesis hydrolysis reactions neutralisation nitration nitriles syntheses oxidation – catalytic/chemical oxidation in liquid phase rearrangement reduction with hydrazine and sodium borohydride sulfonation

VUOS PARTNER FOR COOPERATION 12 Kilolab Unit Phosgenation 2x reactors, 250 and 650 l 2x High performance rectification columns Laboratory phosgenation units from 1 to 30 litres

VUOS PARTNER FOR COOPERATION 13 Kilolab Unit Hydrogenation 3x autoclaves 100 l each, 60, 120 and 130 bar, up to 200˚C, Hastelloy C clad 1x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad 1x autoclave 700 l, 100 bar, 200 o C, stainless steel 1x autoclave 1,000 l, 10 bar, 140˚C, stainless steel many autoclaves up to 10 l

VUOS PARTNER FOR COOPERATION 14 Kilolab Unit Low temperature, RLi, RMgX, NaH 1 x glass reactor 50 l cooled down to – 80 ˚ C 1x glasslined reactor for NaH reactions (250 l) 3x glass reactors 100l for RLi, Grignard reactions

VUOS PARTNER FOR COOPERATION 15 Kilolab Unit 20x glass reactors, 100 l each 6x glass lined reactors (200 – 1,500 l) 2x evaporators 50 l / h 4x stainless steel reactors (300 – 1,500 l) sufficient filtration and distillation capacity Multipurpose chemistry

VUOS PARTNER FOR COOPERATION 16 Production Unit Production Equipment 45x glass lined reactors, total vol. 70,000 l (500 – 5,000 l) 13x stainless steel reactors, total vol. 22,000 l (1,000 – 3,000 l) 8x High performance rectification columns sufficient filtration capacity (nutsches, centrifuges ) computer controlled

VUOS PARTNER FOR COOPERATION 17 Toxicology, Ecology and Analytics

VUOS PARTNER FOR COOPERATION 18 Toxicology / ecotoxicology testing Sampling, analysing, evaluation of production waste streams (air pollution, effluents, solid wastes hazards) Environmental Impact Assessment Development/validation of new specialised analytical methods Toxicology, Ecology and Analytics

VUOS PARTNER FOR COOPERATION 19 Analytical techniques: NMR Spectroscopy Mass Spectrometry (LC/GC-MS) ICP-AES IR Spectroscopy Chromatography (HPLC, GC) UV-Vis Toxicology, Ecology and Analytics

VUOS PARTNER FOR COOPERATION 20 Toxicology, Ecology and Analytics Toxicology: In vivo and in vitro testing according to the OECD or EU methods: Acute toxicity test Skin and eye irritation Sensibilization Repeated dose tests Reproduction toxicity tests Carcinogenicity Mutagenicicty

VUOS PARTNER FOR COOPERATION 21 Toxicology, Ecology and Analytics Ecotoxicological testing: In vivo and in vitro testing according to the OECD or EU methods: Aquatic toxicity Biotic degradation – Ready biodegradability Inherent biodegradability Abiotic degradation

VUOS PARTNER FOR COOPERATION 22 Complete Offer of Services by VUOS  CONSULTING  TESTING  EXPERT WORKS  REGISTRATION REACH and other legislative provisions

VUOS PARTNER FOR COOPERATION 23 Contacts General Manager: Dr. Karel Novák Phone: fax: Sales Manager: Miloš Jesenský,Ph.D. Phone: fax: R&D : Alois Koloničný, Ph.D. Phone: fax: Toxicology and Analytics: Viktor Mejstřík,Ph.D. Phone: fax: Process Engineering: Luboš Víšek Phone: fax: