Hematology. Functions of blood Transportation O 2 & CO 2 Nutrients Waste products Hormones etc. Regulation pH Body temperature Protection Immunity Blood.

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Hematology

Functions of blood Transportation O 2 & CO 2 Nutrients Waste products Hormones etc. Regulation pH Body temperature Protection Immunity Blood coagulation

Blood composing Blood composing: plasma + blood cells

Components of blood : - Plasma - Blood cells (Formed elements)

serum proteins Albumins (60-80%) Most important in maintenance of smotic balance Produced in liver Globulins (α 1, α 2, β & γ) Important in transport of materials through the blood (eg: Iron (transferrin), thyroid hormone Clotting factors Produced by liver, except γ-globulins which are immunoglobulins synthesized by lymphocytes

فرآیند خونسازی 1- همانندسازی سلولهای بنیادی و سلولهای اجدادی خونساز 2- متعهد شدن سلولهای بنیادی جهت تولید یک رده سلولی 3- تکثیر و تمایز سلولهای اجدادی و پیش‏ساز به سلولهای بالغ

Introduction Stem cells Self renewal Plasticity Progenitor cells Developmentally-restricted cells Mature cells Mature cell production takes place from the more developmentally-restricted progenitors

Hematopoiesis PLURIPOTENT STEM CELL COMMITTED PROGENITOR CELL RECOGNIZABLE BONE MARROW PRECURSOR CELL MATURE BLOOD CELL myeloblast monoblast pronormoblastred cell neutrophil monocyte basophil platelet CFU-Baso CFU-Eos CFU-GM BFU-E/CFU-E eosinophil pre-T pre-B myeloid progenitor cell lymphoid progenitor cell lymphoblast T-cell B-cell & plasma cell MIXED PROGENITOR CELL CFU-Megmegakaryocyte pluripotent stem cell

19-13 Hematopoiesis

محل‏های خونسازی 1. خونسازی رویانی و جنینی 2. خونسازی بعد از تولد

Development of Hematopoietic Organs Fetal hematopoiesis Mesoblastic Hematopoiesis Hepatic Hematopoiesis Myeloid Hematopoiesis Hematopoiesis after birth Myeloid Hematopoiesis

خونسازی رویانی و جنینی

خونسازی بعد از تولد در بدو تولد  تمام استخوانهای نوزاد با افزایش سن  بافت چربی جایگزین بافت خونساز می‏شود از 18 سالگی به بعد  تنها استخوانهای تخت و پهن و نواحی پروکسیمال استخوانهای بلند

ساختمان مغز استخوان

Interaction of stromal cells, growth factors and haemopoietic cells

HEMOGLOBIN SYNTHESIS

فاکتورهای رشد خونساز 1. اریتروپویتین (EPO) 2. فاکتور محرک کلنی گرانولوسیت – ماکروفاژ (GM- CSF) 3. فاکتور محرک کلنی گرانولوسیت (G-CSF) 4. فاکتور محرک کلنی منوسیت – ماکروفاژ (M-CSF) 5. ترومبوپویتین (TPO) 6. انواعی از اینترلوکین‏ها (IL 1,2,3,4,5,6,7,….) 7. کیت لیگاند (KL) 8. لیگاند FLT-3 (FL)

Role of growth factors in normal haemopoiesis

Maturation Sequence

Hemopoietic process

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