David J. Grelottia, Ami J. Klina, Isabel Gauthierb, Pawel Skudlarskic, Donald J. Cohena, John C. Gored, Fred R. Volkmara, Robert T. Schultz fMRI Activation.

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Presentation transcript:

David J. Grelottia, Ami J. Klina, Isabel Gauthierb, Pawel Skudlarskic, Donald J. Cohena, John C. Gored, Fred R. Volkmara, Robert T. Schultz fMRI Activation of the Fusiform Gyrus and Amygdala to Cartoon Characters but not to Faces in a boy with Autism Laura Kwon

What is Autism?  Pervasive Developmental Disorder (PDD)  social impairments  deficits in language development  stereotypic or repetitive behaviors  Face perception deficit  Relates to social impairments  Different way of perceving faces  Hypoactivation in the Amygdala and Fusiform Face Area (FFA)

Autistic person - Smaller and more densely packed neurons Damage in Amygdala - Deficits in emotion perception Fusiform Face Area (FFA) Amygdala Composed of… - Middle fusiform gyrus (FG) - Occipito-temporal visual cortical area Most activated by the human face Damage in FFA - Prosopagnosia

Hypothesis FFA & Amygdala of autistic individuals would respond to their special interests despite a lack of activation to faces Previous findings - expertise

Methods  Participants  DD (Autism+Digimon) – 11 yrs - Expertise in Digimon  CC (Autism) – 17 yrs - No expertise/ interest in digimon/ pokemon  TDC (No Autism+Pokemon) – 10 yrs - Expertise in Pokemon, but knew of digimon  Procedure 1. Forced-choice verification task (Behavioural Response) 2. Neuroimaging task (fMRI)

Method - Neuroimaging task  2 sessions  (E1) DD & CC - Unfamiliar faces - Digimon - Nonface objects  (E2) DD & TDC - Familiar faces - Unfamiliar faces - Digimon - Nonface objects

( ) 3.9s 0.3s Stimulus ( ( ( ( 12s 1 Block Same or Different

Results - DD  FFA - No activation to unfamiliar faces - Significant activation to Digimon  Amygdala - Showed bilateral activation for Digimon

Results  DD; FFA & Amygdala responded more to Digimon than to faces or objects  Neither TDC nor CC had greater activation to Digimon than objects or faces

Discussion  FFA  “Face Module” damaged  Expertise  Amygdala  DD found Digimon emotionally meaningful (more salient and rewarding than human face)

Conclusion FFA and Amygdala of Autistic individuals function normally under certain conditions

Personal Opinion  Strengths  Real life application  Various approach  Limitations  Subjects – small #, not well matched  Technical difficulty – part of results lost due to malfunction of the devices  Next Step?  Other special interest or expertise?  Explore possible treatment for autism?

Thank you for listening! Questions?