HST 722 Descending Systems Chris Brown From Slama, unpublished Ascending System: Solid Descending System: Dashed.

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Presentation transcript:

HST 722 Descending Systems Chris Brown From Slama, unpublished Ascending System: Solid Descending System: Dashed

Huge Cortico-Thalamic Projection Injection of HRP In MGB (thalamus) Cortical Labeling: Terminals of thalamo- cortical axons in layer IV (Ascending System) Cell bodies of cortico- thalamic neurons in layers VI and Vb (Descending System) From Peterson and Winer, 1993

Injection SiteTracer CortexFluoroRuby (red) (to label axons & terminals of descending system) Inferior Colliculus (to label cell bodies of the ascending system) contraFast Blue ipsifluorescein dextran (green) Cortical Descending Projections to cochlear nucleus neurons that project to inferior colliculus - studied with multiple tracers From Schofield and Coomes (2005)

From Winer, 2006 Descending Projections of Auditory Cortex

Methods for studying descending systems: 1.Anatomical tracings 2.Activate - electrical stimulation, sound 3.Inactivation - lesion, temporary block (cooling), gene deletion 4.Record responses

From Yan & Suga, 1998 Electrical Stimulation of Cortex changes frequency responses of neurons in the Inferior Colliculus

Lateral (L) OC Neurons Medial (M)OC neurons Originlateral regions near LSOmedial regions near MSO Axon caliberthinthick Peripheral Target auditory-nerve dendritesouter hair cells Olivocochlear (OC) Neurons are a Descending System that Projects from the Olive (superior olivary complex) to the Cochlea

MOC Efferent Fibers Terminate on Outer Hair Cells ResponseAction of MOC Efferents OAEsusually decreased Cochlear Microphonic (CM)increased Afferent Fiber Responsesusually decreased (including compound action potential, CAP) Alpha 9/10 cholinergic receptor on OHCs

SPL Other MOC Functions: 1) Reduce Masking 2) Protection from overstimulation 3) Selective Attention Firing Rate of Auditory Nerve Fiber Activation of MOC Neurons Shifts Rate-Level Functions This shift adjusts the dynamic range of nerve fibers, enabling better signaling at higher levels

OC Activation Reduces Masking in Auditory-Nerve Response

Behavioral experiments suggest tones in noisy backgrounds become harder to detect after lesion of the OC system From May and McQuone, 1995

Recordings from single MOC neurons: Ipsi vs. Contra Response and locations of Neurons

Response of Single MOC Neuron From Brown, 2001

Recordings from single MOC Neurons: Sharp Frequency TuningTonotopic Cochlear Frequency Map Brown, unpublished

What is the pathway of the MOC Reflex?

PVCN Lesions Interrupt the MOC Reflex From Brown et al., 2003

Interneurons are probably PVCN Choppers

Plasticity of OC System?

MOC Postsynaptic Target in Cochlear Nucleus From Benson & Brown, 1990

Auditory Brainstem Reflexes 1.MOC Reflex 2.Middle Ear Muscle Reflex 3.Acoustic Startle Reflex (all are under descending control of higher centers)

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