Institute of Exercise Physiology & Wellness University of Central Florida Muscular Adaptations to Strength Training ExeRcise in Seniors Maren Fragala, PhD, CSCS*D Preventing Sarcopenia

2 Irwin H. Rosenberg, MD (1989)“Sarcopenia” Greek words sarx (flesh) and penia (loss) = the process of age-related loss of skeletal muscle mass and size Reason for creating term: “…no decline with age is as dramatic or potentially more significant than the decline in lean body mass.” “…if this phenomenon were to be taken seriously, we had to give it a name.” Rosenberg IH. Sarcopenia: origins and clinical relevance. J Nutr May;127(5 Suppl):990S-991S.

3 Prevalence of Sarcopenia 14% in those aged 65–69 y New Mexico Elder Health Survey ( ) >50% in those 80 y or older asm/m 2 < 2 SD Baumgartner et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am. J. Epidemiol (8): 755–763.

4 Physical disability was ~ 4X greater in sarcopenic older men and women than in older persons with a normal muscle mass Baumgartner et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am. J. Epidemiol (8): 755–763.

5 No diagnosis NO accepted clinical criteria for diagnosis NO pharmaceutical interventions to treat symptoms Our Objective: To determine if a novel blood biomarker relates to muscle adaptations Implications: Treatment of the debilitating condition Implications: Treatment of the debilitating condition

6 Muscular Adaptations to Strength Training Exercise in Seniors (MASTERS) MASTERS Study Video

7 Skeletal Muscle

8 Blood test

9 Results: (Part 2) Blood Test Fragala MS, et al. Biomarkers of Muscle Quality: N-Terminal Propeptide of Type III Procollagen and C-terminal Agrin Fragment Responses to Resistance Exercise Training in Older Adults. Journal of Cachexia, Sarcopenia and Muscle (In Press). (r = 0.422, p = 0.045) (baseline = to post = )

10 Special Thanks The motivated and dedicated participants! Graduate Students!