High resolution SFOV gamma camera systems

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Presentation transcript:

High resolution SFOV gamma camera systems John Lees University of Leicester

UoL Space Research Centre Technologies and Expertise Optical, UV, X-rays, gamma rays Charge Coupled Devices: CCD XMM-Newton: EPIC

Gamma Cameras and Probes A dual head gamma camera A nuclear probe detector

Mini Gamma Ray Camera (MGRC) Scintillator coated CCD Complementary to “standard” Gamma Camera High spatial resolution (<1mm) Energy range 30-160 keV. International Patents Hand held potential Point of care testing

Mini Gamma Ray Camera (MGRC) e2v CCD 97 BI 16 µm pixels 512 x 512 pixels 8 mm x 8 mm Pinhole collimators: FOV 40mm x 40mm

Camera Schematic The mini gamma camera Columnar CsI Each column acts as a “light pipe” The mini gamma camera

Phantoms

Mini-Phantom

Phantoms 99mTc image of leg and hips Mouse phantom

Comparison with WBGC Hot spot Phantom 99mTc 15 mm

MGRC performance Sub-mm spatial resolution ~0.9mm @ 25mm Interesting Energy Resolution

Clinical Applications & Evaluation lacrimal drainage (eye) Sentinel node detection (breast) Sentinel node detection skin (melanoma) Joint imaging Nasal clearance (drug delivery studies) General surgical exploration in bone (osteoid osteoma) tumour detection, (colon, ovary). thyroid morphology

Sentinel Node Detection RCS New Start Programme 2007-2008: Sentinel Lymph Node Biopsy Training Programme Regionally run programme aimed at all members of the breast care team.

Design evolution - MGRC

Clinical prototype design

Clinical prototype design MGRC in clinical setting MGRC prototype

Clinical trial, QMC Nottingham Tc-99m-HDP bone imaging in patient Conventional gamma camera HR Mini gamma camera

Tc-99m-MIBI Parathyroid Study

Multi-wavelength approach The Milky Way Man Near-Infrared Optical X - rays Gamma rays

Hybrid camera Minimises parallax Minimises image registration problems A combined optical and gamma camera system Co-aligned optical and gamma camera Minimises parallax Minimises image registration problems

Lymph node phantom

Hybrid Imaging

Benefits of SFOV Cameras High spatial resolution (<1mm) Energy range 30-160 keV. Hand held potential Point of care imaging Intra-operative imaging will Improve patient management Increase surgical confidence Reduce surgery time Reduce cost of treatment

Acknowledgements Space Research Centre, Leicester David Bassford, Oliver Blake, Tony Abbey, George Fraser, Duncan Ross, Chris Bicknell Massimiliano Canali University of Nottingham Alan Perkins and Elaine Blackshaw De Montfort University Peter Ford and Lee Cottrell