The Neuromuscular Junction Chapter 10 Anatomy and Physiology Mr. Knowles Liberty Senior High School.

Slides:



Advertisements
Similar presentations
SYNAPSES AND DRUGS.
Advertisements

Skeletal Muscle Activity: Contraction
Muscle Contraction Muscles - part 3.
A Slides 1 to 110 Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings.
Neuromuscular Junction
The Muscular System Chapter 6 Muscle Contraction.
Muscles and Muscle Tissue
Figure 10.6 Structure of the Neuromuscular Junction Process Diagrams Step-by-Step Copyright © 2007 by John Wiley & Sons, Inc.
Copyright © 2009 Pearson Education, Inc. Figure 6.4b Muscle cells.
Anatomy and Physiology I
Sliding Filament Mechanism
Muscle Physiology Human Anatomy and Physiology.  Beneath the sarcolemma of a muscle fiber lies the sarcoplasmic reticulum (endoplasmic reticulum), which.
Histology of Muscle.
{ Nerve Stimulus and Action Potential Bella Veri Brandon Richter Haily Walker Deva Ramos Jenny Le Period 4.
How Does A Motor Unit Illicit A Muscular Contraction.
NEUROMUSCULAR JUNCTION DR. ZAHOOR ALI SHAIKH LECTURE
Signals Passing Through Neuromuscular Junction 4 th Period: Breanne Gomez, Haleigh Eary, Hanna Hollman, Yazmin Baldonado.
BY: STEPHANIE MARTELLA THE CHEMISTRY OF A MUSCLE CONTRACTION.
The Muscular System What do skeletal muscles do? How do muscles work?
Skeletal Muscle Key words:. Overview of the Muscle Fiber Structure Muscle fibers (cells) are composed of myofibrils Myofibrils are composed of myofilaments.
Physiology of a Muscle Contraction Human Anatomy and Physiology Dr. Steve W. Altstiel Naples Middle High School.
Muscle Contraction. Muscle Movement Muscle fiber must be stimulated: – By an electrical signal called muscle action potential (AP) – Delivered by motor.
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Muscle Contraction.
Pages  Stimulus generated capabilities: ◦ Irritability (also called responsiveness)—ability to receive and respond to a stimulus ◦ Contractility—ability.
Nerve Supply to Skeletal Muscle. Nerve Supply The outside of the nerve plasma membranes contain a slightly positive charge (Na+). The inside of this same.
Neuromuscular Junction (NMJ). Neuromuscular junction Neuromuscular junction : the synapse between motor neuron and muscle fibre Motor neurons : are the.
The Neuron An everyday (every second!) use of active transport
Contraction of skeletal muscles. Energy Needed for Contraction 1. Aerobic Respiration (oxidative phosphorylation) Majority of ATP comes from this process.
Motor Unit: A motor neuron and all the muscle fibers it innervates. *Powerful movements use more fibers *Fine movements use fewer fibers.
1 Membrane Potentials (Polarity) Information found in 2 places: –Chapter 3 - pp –Chapter 9 - pp /22/12 MDufilho.
Ch : Contraction and Metabolism of Skeletal Muscle
Evolutionary pharmacology at the neuromuscular junction W. Rose.
Synapse – The site of connection between a neuron and a cell. Neurotransmitter – A chemical released at the neuron’s synapse that communicates with the.
The Neuron An everyday (every second!) use of active transport.
Myelin again Myelin speeds up the nerve impulse because nerve fibers have Schwann cells around them – Schwann cells restrict ion movement – So impulse.
Skeletal Muscle Contraction
The Neuromuscular Junction
Neurophysiology II: The Synapse Synapse Defined Space between adjacent neurons! Relays information from one neuron to another! Neuron  Neuron Neuron.
Neuromuscular Junction and Major Events of Muscle Contraction Quiz Review.
09.12 Function of the Neuromuscular Junction Slide number 1 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Neuron Function The Membrane Potential – Resting potential Excess negative charge inside the neuron Created and maintained by Na-K ion pump Copyright ©
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings WHOLE MUSCLE CONTRACTION:PART 1 Motor units All the muscle fibers innervated.
The Muscular System What do skeletal muscles do? How do muscles work?                      
Muscle Contraction Chapter 9 Part B. How does the anatomical structure function physiologically? What is the importance of the membranes? Why is it important.
Muscle Contractions. Muscles pull on tendon fibers Pull=Tension Tension is an active force Energy must be applied to produce an active force Applied tension.
Nerve Supply to a Muscle. Nerve Supply Motor Neuron: Nerve that stimulates a muscle cell. A single nerve (motor neuron) will supply approximately 150.
The Muscular System PP # 3 Contraction
The Muscular System What do skeletal muscles do? How do muscles work?
2. Striation Pattern of Sarcomere
9 Muscles and Muscle Tissue: Part B-Muscle Contraction and Signal Transmission.
Nerve MUSCLE PHYSIOLOGY
LECTURE 15 NEUROMUSCULAR JUNCTION
9 Muscles and Muscle Tissue: Part B.
The Muscular System What do skeletal muscles do? How do muscles work?
Introductory Skeletal Muscle – Histology Flash Cards
Physiology of Muscle Contraction
The Neuromuscular Junction
1. An action potential arrives at the
SYNAPSES AND DRUGS.
SYNAPSES AND DRUGS.
Communication Between the Nervous System and Skeletal Muscles
1. An action potential arrives at the
How do Muscles Contract?
Chapter 7 Excitation of Skeletal Muscle
MUSLCES PART 2 HOW DO THEY WORK?.
Neuromuscular Junction
SYNAPSES AND DRUGS.
Physiology of Muscle Contraction
Skeletal Muscle Fibers
Nerves and Muscles.
Presentation transcript:

The Neuromuscular Junction Chapter 10 Anatomy and Physiology Mr. Knowles Liberty Senior High School

Neuromuscular Junction (NMJ) Communication b/w the nervous system & skeletal muscle fiber.

Soma

Neuromuscular Junction (NMJ) As an axon enters a muscle, it branches into a number of synaptic terminals synaptic terminals, each of which forms a NMJ with a single muscle Fiber.

Synaptic Terminal Acetylcholine (ACh).Contains Molecules of Acetylcholine (ACh). AChACh is a neurotransmitter, chemical released by neurons to change the membrane properties of other cells.

Synaptic Cleft narrow spaceA narrow space that separates the synaptic terminal of the neuron from the sarcolemma surface. (AChE) AchContains Acetylcholinesterase (AChE) which breaks down Ach.

Motor End Plate ACh.The surface of the sarcolemma that contains membrane receptors that bind ACh.

When a neuron stimulates a muscle fiber, Heeeeere’s what happens...

The arrival of an action potential Sudden change in the transmembrane potential along the axon. AChThis stimulates the release of ACh at the synaptic terminal.

The release of ACh ACh,Vesicles that contain ACh, in the synaptic terminal, fuse with the membrane of the neuron & are released by exocytosis into the synaptic cleft.

ACh binding at the motor end plate ACh ACh receptorsACh molecules diffuse across the synaptic cleft & bind to ACh receptors on the motor end plate’s surface. ACh (Na + )When ACh binding occurs, sodium ions (Na + ) now can rush into the sarcoplasm.

Appearance of an action potential in the sarcolemma Na +The Na + results in an action potential in the sarcolemma. T tubules Ca 2+ terminal cisternae.The action potential sweeps across the entire membrane surface & travels down each of the T tubules which triggers the release of Ca 2+ at the terminal cisternae. AChE ACh.While this is occurring, AChE removes the ACh.

Return to the initial state ACh AChEEven before the action potential has spread across the entire membrane, the ACh has been broken down by AChE. This sequence of events can now be repeated, should another AP arrive at the synaptic terminal

Normal

Show me the action! Potential, that is!

What happens at the neuromuscular junction when exposed to botulinum toxin?

Effects of a Nerve Agent

Atropine Antidote

What is myasthenia gravis?