STRIATED SKELETAL MUSCULAR TISSUE

FUNCTIONS Movement Heat Stabilization

TYPES Striated Skeletal Voluntary Striated Cardiac Involuntary Visceral Smooth Involuntary

PROPERTIES Contractibility Excitability Extensibility Elasticity

FASCIA Tendon of Origination Epimysium Perimysium Endomysium Tendon of Insertion

MYOFIBER STRUCTURE Sarcolemma Sarcoplasm Sarcoplasmic Reticulum –Transverse Tubule –Triad –T Tubule –Terminal Cisterna Multinuclear Mitochondria Myofibrils

MYOFIBER MYOFILAMENTS Contractile Proteins Actin Myosin Regulatory Proteins Troponin Tropomyosin Structural Proteins Titin Nebulin Myomesin Dystrophin

SARCOMERIC AREAS Z Disc I Band A Band H Zone M Line I Band Z Disc

METABOLISM OF MYOFIBER Anaerobic Respiration –Glycolysis 2 ATP’s / Glucose 2 Trioses / Glucose 2 NADH2 / Glucose

AEROBIC RESPIRATION Transition Reaction –2 Pyruvic Acid / Glucose –2 NADH2 / Glucose Citric Acid Cycle –2 ATP’s –2 FADH2 / Glucose –6 NADH2 / Glucose Electron Chain Transport

BLOOD SUPPLY Myofiber –Capillary Arterial Venous

NEUROMUSCULAR JUNCTION Somatic Motor Neuron –Dendrites –Cell Body –Axonic Hillock –Teleodendria –Synaptic End Bulb –Synaptic Vacuole –Exocytosis –ACH –Synapsis –Diffusion

NEUROMUSCULAR JUNCTION Myofiber –Sarcolemma –Ach Receptor –Transverse Tubule –Na+ Gates Open –Na+ Influx –Transverse Tubule –Triad

NEUROMUSCULAR JUNCTION Myofiber –Triad –Terminal Cisternae –Ca+2 Gates Open –Ca+2 Sarcoplasmic Diffusion –Activated Troponin –Activated Tropomyosin –Troponin Tropomyosin Complex –Exposed Actin

NEUROMUSCULAR JUNCTION Myofiber –Ca+2 Sarcoplasmic Diffusion –Myosin Cross Bridges –ATP Myosinases –Dephosphorylation of ATP –Diphosphate Bonds Broken –Energy Released –ADP and Free High Energy

NEUROMUSCULAR JUNCTION Myofiber –Actin-Myosin Lock Up –Myomesin Pulls on Myosin –Myosin Pulls Actin –Myosin and Actin in H Zone –H Zone Disappears –Sarcomere Shortens –Z Disc –All Sarcomeres Shorten

NEUROMUSCULAR JUNCTION Myofiber –Dystrophin –Sarcolemma –Endomesium –Perimesium –Epimesium –Tendon of Insertion

NEUROMUSCULAR JUNCTION Remove Threshold Stimulus –Na+1 Gates Close –K+1 Gates Open –Repolarization –Refractory –AChE –Actin-Myosin unlock –Troponin-Tropomyosin Complex unlock

NEUROMUSCULAR JUNCTION Remove Threshold Stimulus –H Zone Reappears –Sarcomeres Return –Ca+2 Transported to Organelle of Storage –Calsequestrin –Ca+2 Gates Closed –Expenditure of Energy

MOTOR UNIT One Somatic Motor Neuron 150 Myofilbers Epimesium Tendon of Insertion

TWITCH CONTRACTION Response to One Stimulus Latent Period Contraction Period Summation Period Refractory Period Relaxation Period

APPLICATION OF STIMULI Treppe Complete Tetanic Incomplete Tetanic Wave Summation –Smooth Summation –Rough Summation

MUSCULAR TONUS Partial Contraction Involuntary Contraction

TYPES OF MOVEMENTS Isotonic –Examples: Isometric –Examples:

TYPES OF MUSCLES Red Muscles –# Myoglobin –Slow –Examples: White Muscles –# Myoglobin –Fast –Examples:

TYPES OF MUSCLES Red and White Mixture –# of Myoglobin –Examples: