(1) Dynamics of CD4 + T cells, X(t) Generated from the thymus at a rate ; is the fraction of cells inhibition by AZT; Loss due to finite lifespan at a.

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Presentation transcript:

(1) Dynamics of CD4 + T cells, X(t) Generated from the thymus at a rate ; is the fraction of cells inhibition by AZT; Loss due to finite lifespan at a rate ; Generated by Antigen(A)-induced proliferation at a rate. These can be summarized in the differential equation:

(2) Dynamics of T cells, Y(t) Generated from the thymus at a rate ; Loss due to finite lifespan at a rate ; Generated by Antigen-induced proliferation with the help of T cells at rate. Thus:

(3) Dynamics of antigen(A)- specific CTLs, C(t) Generated from antigen-specific T cells with the help of T cells at a rate of ; Loss due to natural death at a rate. This gives:

(4) Dynamics of antibody- producing B cells, Z(t) Generated from bone marrow at a rate ; Loss due to natural death at a rate ; Generated by Antigen-induced proliferation with the help of T cells at a rate. Then:

(5) Dynamics of Antigen, A(t) Produced due to vaccination or infection at a rate ; Loss due to B cells at a rate.

Summary In summary, the model consists of the equations:

ANALYSIS OF THE MATHEMATICAL MODEL The model has been analyzed and found to be mathematically stable and therefore suitable for computer simulation.

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