The Role of Cortisol in Health & Longevity Presented by William Kraemer, Ph.D. Professor of Kinesiology University of Connecticut This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.

What is Cortisol? Cortisol is the body’s primary stress hormone “Fight-or-Flight” response Regulates inflammation, carbohydrate metabolism, cardiovascular function, etc… BUT too much cortisol for too long leads to health concerns

Normal Diurnal Cortisol Rhythm

Cortisol Response to Stress Epel et al. Psychosom Med 2000;62(5):623-32

Trier Social Stress Test (public speaking & arithmetic) M. Altemus, Cornell University.

Cortitrol™ STRESS CONTROL FORMULA Supports healthy cortisol levels* Presented by Shawn Talbott, Ph.D. Director, Scientific Affairs Pharmanex, LLC This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited. * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

What is Cortisol? Cortisol is the body’s primary stress hormone “Fight-or-Flight” response Required by the body for survival Regulates carbohydrate metabolism, cardiovascular function, etc… BUT too much cortisol for too long leads to problems Repeated exposure to stressful situations (personal, family, work) Modern stressors do not permit fight or flight Stress hormones may not dissipate Stress leads to health consequences

Stanford stress researcher Robert Sapolsky, PhD Stanford stress researcher

Cortitrol™ Helps Control Cortisol to Cope with Stress

Cortisol Levels Are Elevated In... Stressful situations Sleep deprivation Dieting / Restrained eating Adults who need to control cortisol levels are… Frequently confronted with stressful situations Getting less than 8 hours of sleep every night Generally feel run down, lack mental focus Limiting caloric intake to lose weight

Stress and the Workplace Psychological demands at work that exceed one’s capacity to cope produce a variety of physiological responses that, over time, lead to health concerns. Work demands and low level of job control lead to changes in cortisol levels. Ganster et al. Journal of Applied Psychology, 2001, 86, 954-964.

Cortisol in the Media More Than 1,000 News Articles Over the Past Year! Time, Washington Post, Men’s Health, Prevention, Glamour, Shape, Woman’s World, Reader’s Digest, Reuters, ABC, MSNBC… 1st International Symposium on Cortisol, Stress and Health May 2002 - Experts from United States, Canada, and Europe gathered in Park City, Utah presented emerging research related to cortisol New Book: The Cortisol Connection Published September 2002

The Solution: Cortisol Management You can control cortisol levels via: Stress Management Techniques meditation, coping strategies, etc… Exercise Pharmanex Body Design Nutrition Dietary Supplements* LifePak™ + Cortitrol™ STRESS CONTROL FORMULA * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Common Anti-Stress Solutions Valerian Kava Kava Melatonin Tyrosine None of these supplements directly address cortisol control

Cortitrol™ STRESS CONTROL FORMULA - Health Benefits - Enhances feelings of wellbeing and control in response to stressful situations* Improves performance and increased vigor throughout the day* Better mental concentration and focus* Supports weight maintenance efforts* Hint… CORTITROL for CORTIsol conTROL * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Proprietary Stress Control Formula Comprehensive formula addresses both direct cortisol modulation and stress control Scientifically-validated ingredients in clinically significant dosages Magnolia Bark (2% Honokiol), Ashwagandha, Passion Flower Epimedium (6:1 water extract), Garlic L-Theanine (70:1 all-natural extract) Phosphatidylserine Beta-sitosterol

Scientific Substantiation Magnolia Bark anti-stress effects; non-sedating Epimedium reduces cortisol levels during high stress; promotes energy levels L-Theanine increase alpha brain wave production; promotes relaxed alertness and concentration; non-sedating Phosphatidylserine reduces cortisol levels following strenuous exercise; improves mental function Beta-sitosterol balances cortisol:DHEA ratio; supports immune function *References available from Pharmanex, LLC

Competitive Advantage First patent-pending dietary supplement that supports healthy cortisol levels* Proprietary blend + Comprehensive Approach Modulates cortisol levels Helps combat stress Improves mental function Contains a proprietary, all-natural form of theanine extracted from green tea leaves Manufactured according to the Pharmanex® 6S® Quality Process * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Recommended Usage Combine with LifePak® Family Everyone should use Cortitrol! Frequently confronted with stressful situations Getting less than 8 hours of sleep every night Generally feel run down, lack mental focus Limiting caloric intake to lose weight Combine with LifePak® Family Vitamin C, B vitamins, calcium, magnesium Directions for Use Take 2 capsules with your evening meal. For optimal results take an additional (1) capsule with your morning meal.

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