Bioinformatics The newest science The integrating science.

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Presentation transcript:

Bioinformatics The newest science The integrating science

Bio + informatics

Examples Analysis of the information content of genomes Sequence analysis and sequence alignment Most computational aspects of drug design Data mining in biological databases Model macromolecular structures/complexes Biological pathway analysis Crop and animal stock improvement Phylogeny

The human genome

Chromosomes

……….the sequence……….....acccaa gaagtcagaa tcctcgaagc tgaagcctga ctgtaagctc tgcctcctac aactagacaa gtcacaatgc aacccctttg ctccagagga aaaggagtaa gcacagaggg cttctgagtc cggcaatgct ccatttcctg acaggagcat tttacagact tgcgtctgcc cctctgaggg aggcagggcc atcagctaac actcagagac aaggatggtc ctacaacatc ctgatctggg aggaagaggt gaaggcaact caccaccctc aggcatctta acagaaaaca gtggaactaa ggctcattct aaagaatgtg cccaagatca cacaccgaag gctgcaaagc gagagtcaaa cttggaaccc tgaacctgca cttgtccctt tacactgccc tgcagcatgg atgcgatggc tgggcagagg gaagtgccca agcctgggga caaaaatgcc tacctg.... One cubic meter of floppy disks needed to store it all.

Exaggeration competition

Reality (?) The human genome will be known and properly annotated in a few years. At that moment we know nearly all targets for medicines.

Genome annotation

Bioinformatics and medicine

Drug Design

One genome not enough Parasite Active site

Bioinformatics and medicine

One genome not enough

Sequences Sequence alignment is the best tool for transferring information from a well studied molecule to a more poorly studied molecule.

Sequences CPISRTWASIFRCW CPISRT---LFRCW CPISRTWASIFRCW CPISRTL---FRCW

Sequences CPISRTEASNFRCW CPISRTQ---FRCW CPISRTEASNFRCW CPISRT---QFRCW

Sequences 1-ASTCIPLKCMMHPICDDERTCASTCF 2-STVLIPIRCMIHPICEEDQVAATTCY 3-ASSCIPPKSMMHPVVDEEKTCASSCF 4-ASTLIPIPVMIHPVVERDKVAAXSCW 5-ASSCIPPPSMMHPIVEEDQVCATTAF 6-ASSCIPIRCMMHPICEEDKVCASSAY 7-ATSLIPPKCMIHPVCDDDRTAASSAT

Data and databases

And now the propaganda Biologie, Scheikunde, Informatica: Wel leuk. Maar je wilt van alles wat. BIOINFORMATICA!! Waar: KUN, Faculteit NWI (In toekomst vermoedelijk op vijf plekken in Nederland).

medicijnen wiskunde en statistiek moleculaire levens wetenschappen scheikunde infor- matica natuurweten- schappen biologie BIO- INFORMATICA BIOINFORMATICA overstijgt disciplines

Opleidingen scheikunde biologie & medische biologie natuur-wetenschappen informatica en informatie kunde moleculaire levens-wetenschappen life sciences wiskunde natuur- en sterrenkunde milieu- natuur-wetenschappen Faculteit Natuurwetenschappen, Wiskunde en Informatica 5 subfaculteiten scheikunde natuurkunde biologie wiskunde informatica

Studeren aan deze faculteit Basis Orientatie Differentiatie Onderzoek Beroepsvoorbereiding

Vakkenpakketten voor toelating Scheikunde N&T; N&G; WiskB+Nat Biologie N&G; N&T+Biol1&2; Bio+Sk Natuurwetenschappen N&T; N&G+WiskB2; Nat+WiskB Informatica N&T; N&G+WiskB2; WiskB Moleculaire Levenswetenschappen N&T; N&G; WiskB+Nat

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