Project funded by the Future and Emerging Technologies arm of the IST Programme NEUMIC Project No. IST-1999-29091 Neurons and Modified CMOS Integrated.

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Project funded by the Future and Emerging Technologies arm of the IST Programme NEUMIC Project No. IST Neurons and Modified CMOS Integrated Circuits Interfacing Imec The Hebrew University of Jerusalem Physics, Chemistry,Biology

Project funded by the Future and Emerging Technologies arm of the IST Programme Neuro-Electronic Synapse (NES): interact with neuronal communication bi-directional electrical communication uni-directional chemical communication eNEScNES action potential neurotransmitter

Project funded by the Future and Emerging Technologies arm of the IST Programme Neurons on a chip

Project funded by the Future and Emerging Technologies arm of the IST Programme Recorded action potential V [10 2 uV] V [mV] V [10 2 uV] V [mV] time [sec] RAW FILTERED ( Hz) FG tor output intracellular voltage

Project funded by the Future and Emerging Technologies arm of the IST Programme A hybrid transducer for molecular recognition events “artificial acetylcholine synapse” neuronal pre-synaptic element electronic post-synaptic element modulated current modulated current molecular recognition event

Project funded by the Future and Emerging Technologies arm of the IST Programme cNES: towards an artificial synapse AcetylCholine-Esterase ISFET acetic acid SAM of AChE ACh fast (35 sec) & sensitive (10 -8 M)

Project funded by the Future and Emerging Technologies arm of the IST Programme Achievements so far, and future Fabrication of 1 st generation experimental Si neuron transistor chip (single neurons, extended floating gate, depletion type,shielding metals, SiO 2 Ta 2 O 5 ) New package designed and realized (flip chip bumping, large exposure of Si area, easy access microscope, microprobes..) Recorded signals from stimulated neurons cultivated on chip Experimental verification of “Molecular amplifiers” based on chromophores Improved neuron adhesion layer, next to polylysine Assessment and verification of chemical sensing principle by direct and quantized measurements of ACh Second generation transistors designed, processing start end of December (improved S/N, improved processing, multiple neurons, bi-directional…) Selection of improved surface biologization molecules and patterning Direct measurement of ACh on chip On chip stimulation and recording of neurons

Project funded by the Future and Emerging Technologies arm of the IST Programme No major delays on deliverables Interactiva’s tasks have been divided between partners Expected successful completion of 3th year if extension till December 2003, no show stopper yet Second run and purchase of peptides, sacharides necessary and possible after administrative problems are solved, expected December 2002 Agreement from project officer obtained summer 2002 Conclusion

Project funded by the Future and Emerging Technologies arm of the IST Programme Changes to the workplan Second generation transistors Surface biologization Technology implementation plan