Agnes Scott College Department of Chemistry (an American Chemical Society approved program) Program in Biochemistry and Molecular Biology (BMB)

Why Major in Chemistry or BMB?  Career Opportunities  Research (industry, biomedical fields)  Academic chemist (biomedical, biological)  Medical school  MD  MD/PhD  Teaching (MAT)  Law school  Library science

What do our majors do?  Sara B. – second year graduate student at Northwestern University  DeeDee S. – third year graduate student at Northwestern University  Patrice B. – 2003, Ph.D. Purdue University, Dreyfus Fellow, Ga. Instit. Tech.  Nina T. – Research Fellowship, CDC  Abena F. – Rollin’s School of Public Health  Sara S. – CDC Fellowship in Namibia  Mary F. – 1 st year graduate student at Emory

Chemistry Faculty  Doug Fantz, Assistant Professor  Biochemistry, organic chemistry, first year seminar  Lilia Harvey, Associate Professor  Organic chemistry, senior seminar  Ruth Riter, Assistant Professor  Analytical chemistry, introductory chemistry, quantitative analysis, environmental chemistry  Leon Venable, Associate Professor  Introductory chemistry, bioinorganic chemistry, advanced inorganic chemistry  Patrice B., sabbatical replacement for  Sara Winget, Visiting Professor  Physical chemistry, introductory chemistry

Courses of Study  Regular Chemistry Major  ACS (American Chemical Society) Approved Chemistry Major  Chemistry Minor  Biochemistry & Molecular Biology (interdisciplinary major with biology) (interdisciplinary major with biology)

Chemistry Curriculum non-ACS degree ClassDescriptionHoursNon-Chem Pre/corequisites 101/101LMatter and Rxns4 102/102LPeriodicity4 201/201LOrganic I4 202/202LOrganic II4 301/301LP. Chem. I4Math 118,119,220(R); Physics 110, P. Chem. II4 311Quant. Chem. Anal.4 312Instrumental4Physics 242,243 (electronics (2 hr each)) 342L/343LPhys. and Inst. Meth.1/1 431/LMod. Inorg.4 VariableAny advanced chem.4 Total Hours42Total hours w/ prereqs62 ; 66(R) ACS certified degree -addition of Biochem. I Minor 2 courses beyond 202

BMB Curriculum Courses Required Biology Chemistry BIO 191 : Molecular and Cellular BiologyCHE 101/101L : Fund. Concepts of Matter and Reactions BIO 192 : Genetics and Developmental BiologyCHE 102/102L : Periodicity and Chemical Reactions BIO 316 : Molecular BiologyCHE 201/201L : Organic Chemistry I BIO 300 / CHE 300* : Biochemistry ICHE 202/202L : Organic Chemistry II CHE 300 / BIO 300* : Biochemistry I plus one of the following BIO courses:CHE 301 : Physical Chemistry I CHE 342L : Physical and Instrumental Methods of Exp. I CHE 400 : Biochemistry II BIO 301 : Microbiology BIO 309 : Cells and Tissuesplus one of the following CHE courses: BIO 315 : Genetics BIO 317: Immunology BIO 318 : Developmental BiologyCHE 210 : Bio-inorganic Chemistry CHE 302 : Physical Chemistry II CHE 311 : Quantitative Chemical Analysis * Note: BIO 300 and CHE 300 are cross-listed courses, and either (but not both) can be taken to satisfy the major. ** Note: CHE 301 requires MAT 118 & 119 as well as PHY 110 & 111. Research Requirement

Course features  Small classes  Small labs  Labs are taught by Ph.D. chemists  Hands-on access to equipment  Collaborative research opportunities

Research Opportunities  Research with chemistry and biology faculty members  Interdisciplinary research with faculty from other disciplines  Research collaborations (interdisciplinary or strictly chemical) with scientists at other institutions

Doug Fantz- Biochemistry  Investigation of the Ras pathway using C. elegans as a model organism C. elegans lin-3 let-23 sem-5 let-60 lin-45 mek-2 mpk-1 lin-1 1˚ vulval fates H. sapiens EGF EGFR GRB2 RAS RAF MAPKK MAPK Elk-1 proliferation

Lilia Harvey – Organic Chemistry Photochemistry of Alpha-(Aryloxy) Acetophenone and Derivatives

Ruth E. Riter – Analytical Chemistry Photoinduced Electron Transfer Across Reverse Micellar Interfaces

T. Leon Venable – Inorganic Chemistry (1)Synthesis and Characterization of Ru-B Clusters as Potential Cancer Therapy Agents (2)Synthesis and Characterization of Cu-Amino Acid Complexes

Sarah Winget – Physical Chemistry - use of vibrational spectroscopy to design and characterize surface and interface chemistries SEM image from Zhao et al, International Journal of Nanoscience, 1, (2002) 87-97

New Equipment  ~ $750,000 worth of new equipment and equipment upgrades  Spectroscopy: UV-VIS, FT-IR, Laser, Raman  Separatory/analytical: GC, GC/MS, HPLC, CE  Structural/analytical: NMR – 400 MHz  Probe microscopy: STM/AFM  Data acquisition

Scanning Tunneling Microscopy STM / Atomic Force Microscopy AFM 2.5 Å STM Image of Graphite Molecular Model of Graphite

NMR Nuclear Magnetic Resonance –Same process as used in MRI (Magnetic Resonance Imaging) 400 MHz –Greater sensitivity –Can study proteins –Other resonances C-13, B-11, P-31, etc.

Student Affiliates of the American Chemical Society  Active student chemistry organization  Four-time national award winners for chapter activities  Outreach activities  Tutoring  Chemistry shows & demonstrations  Campus open-house activities

Questions?  Dr. Douglas Fantz  SC301W  x-5067 