1 Centre of Excellence in Bio-safety and Molecular Biomedicine - „BioMoBiL” Sixth Meeting of the Working Package WP7 „Final Report and What Did We Achieve ?” Gdańsk, 29 June 2006 Department of Biology and Pharmaceutical Botany, Faculty of Pharmacy, MUG Coordination Office: Andrzej C. Składanowski Ewa Kiszka

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3 Research focus of BioMoBiL - applications  Chromosomal genotyping,  Molecular markers for cancer diseases  Molecular diagnostics for invasive diseases,  Composed polyvalent vaccines (salmonellosis)  Recombinant vaccines for animal viral diseases etc.  Molecular markers for detection of plant pathogenic bacteria,  Biological tests for detection of mutagenic polution of marine environment,  New photosensitizers in photodynamic therapy of cancer,  Pharmacologically active plant secondary metabolites

4 Research focus of BioMoBiL – basic sciences  Novel mechanisms of DNA replication regulation,  Molecular chaperones in organization and function of nucleoids,  Genetic polymorphism and conservation of biodiversity of medicinal plants, carnivorous plants, orchids, limnofauna and vertebrates

5 Summary of activities in a pill April 2003 – June 2006 (3.25 yrs)  102 visitors in the Centre (expected 34 more for the Summer School + 10 International Advisory Board)  137 Centre members visited abroad  66 domestic visits  Summer Schools of Biotechnology (2003, 2004, 2005, expected 2006)  Centre Conferences with IAB Meetings (Taylor Conference 2003, 2nd BioMoBiL Conference 2005, expected 3rd Conference in 2006) BioMoBiL Conference 2005, expected 3rd Conference in 2006)  3 other conferences (Scan-Balt Conference 2003, International Student Scientific Conference 2004, European Workshops on the Molecular Biology of Scientific Conference 2004, European Workshops on the Molecular Biology of Cyanobacteria, 2005) Cyanobacteria, 2005)  Workshops about intellectual property protection (expected 1 at BSS),  2 Established IP data bases (herbal plants, cell lines) and Eucaryotic Cell Bank Bank  Established website: databases with equipment, services, methods, books and materials available in the Centre, visibility in the Internet and materials available in the Centre, visibility in the Internet

6 Mobility - number of visits Mobility - number of visits WPVR V1, V2 1 (Centre Conferences) -9 2 (Summer schools) (Twinning) (Networking) (Capacity building) 84 6 (Collections, Data Bases) 51 7 (Laboratory Techniques) (Commercialization) 1- 9 (Coordination) 76

7 Mobility – countries CountryVR V1 + V2 Germany1517 Italy78 France53 Netherlands86 Belgium52 United Kingdom 137 Spain51 Portugal11 Austria1- NAS excl. Poland 58 Poland42- Sweden113 Norway5- Ireland2- Switzerland11 Denmark2- Finland135 Czech Republic -2 Macedonia-1 USA/Canada3-

8 Mobility – visiting and revisiting Mobility – visiting and revisiting WP Both way visits (VR + V1/V2) Turku, Finland 4 Muenster, Ibbenbueren, Germany Leuven - Belgium Leiden, Wageningen - The Netherlands Perugia, Ancona - Italy Shiefield, London – UK Lisbon – Portugal Umea, Uppsala - Sweden 8- 9-

9 Summer Schools of Biotechnology, Sobieszewo and Lapino Topics : 1.Plant biotechnology. 2.Molecular diagnostics of viral and neoplastic disease. 3.Bioinformatics – molecular evolution and protein structure. 4.Genomics, microarrays, molecular diagnosis of cancer. 5.Biotechnological applications in agriculture. 6.White, green and red biotechnology. Topics 2005: 1.Proteomics. 2.Molecular components of transducing pathways. 3.Bio-process engineering. Topics 2006 (expected): 1.Molecular diagnostics of infectious diseases. 2.Molecular diagnostics of cancer diseases. 3.Immunotherapy of cancer. 4.Stem cells. 5.Intelectual propoerty rights. Lectures Seminars Workshops CDs BioMoBiL Library S T U D E N T S

10 Infrastructure available in the Centre  Multi-media projector + laptop  Data base system for herbarium and other collections  Cell & Tissue Bank, deep freezers, RT-PCR equipment  BioMoBiL Library, ca. 50 books,  4CDs (Summer Schools lectures and books listed on www)

11 Eucaryotic Cell Banking – IRC Success Story

12 Achievements of BioMoBiL compared to other Centres of Excellence NAS2

13 Cost summary – 3.5 years  1st year , 88 Euro  2nd year , 07 Euro  3rd year , 49 Euro  4th year - spent mths ca Euro - engaged for mths ca Euro - - engaged for BSS, IAB ca Euro ______________________________________________ Planned summary spending: , 24 Euro (ca 94 % of total) Total contracted sum: Euro

14 What for the future ?

15 ScanBalt - BioMoBiL Molecular Diagnostics Knowledge Centre Coordinated by the Intercollegiate Faculty of Biotechnology University of Gdańsk & Medical University of Gdańsk

16 Micrometastasis Diagnostics: Prof. Klaus Pantel, Hamburg; Dr. Björn Naume, Oslo Department of Biotechnology IFB UG-MUG Molecular Diagnostics Division Prof. Fabien Zoulim, Dr Lycyna Cova INSERM U271, Lyon France Prof. Burkhard Brandt University Medical Center Center of Experimental Medicine Institute for Tumour Biology Hamburg, Germany Dr Guy Vernet Emerging Pathogens R&D Dept. bioMerieux, Lyon, France Prof. Torkel Wadström Section of Med. Microbiology Dept. of Laboratory Medicine Lund University, Sweden Oncology diagnostics Diagnostics of infectious diseases viRgil - Network of Excellence ScanBalt BioMoBiL Dr Ulf Vogt Institute of Molecular Oncology European Laboratory Association Ibbenbueren, Germany (private lab) H U B H U B

17 Prof. Hans-Joachim Rziha, Inst. for Animal Health, Tubingen, Germany Prof. Hans Nauwynck, University of Ghent, Belgium Intercollegiate Faculty of Biotechnology UG-MUG Dr. Jan van der Volf PRI, Wageningen, The Netherlands Prof. Thomas Bergstrom, University of Goteborg, Sweden Prof. Emmanuel Wiertz, University of Leiden, Holland Dr Ian Barker, CSL, York, Great Britain Prof. Gunter Adam, University of Hamburg BRD, Germany Diagnostics of human & animal viral diseases Diagnostics of plant pathogens BioMoBiL ScanBalt Prof. Arvind Patel, MRC, Glasgow, Scotland H U B H U B