BIO 344 Lecture 2
Figure 10-11a Molecular Biology of the Cell (© Garland Science 2008)
Formation of sphere is energetically favorable
Figure 10-9a Molecular Biology of the Cell (© Garland Science 2008)
Figure 10-9b Molecular Biology of the Cell (© Garland Science 2008)
Figure 10-11b Molecular Biology of the Cell (© Garland Science 2008)
Figure Molecular Biology of the Cell (© Garland Science 2008)
Figure Molecular Biology of the Cell (© Garland Science 2008) Effect of cis double bonds on membranes
Figure Molecular Biology of the Cell (© Garland Science 2008) 1:1 phosphotidylcholine and sphingomyelin 1:1:1 phosphotidylcholine and sphingomyelin and cholesterol
Figure 10-14b Molecular Biology of the Cell (© Garland Science 2008)
Figure 10-14a Molecular Biology of the Cell (© Garland Science 2008)
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Cholesterol 9
Cholesterol in lipid bilayer
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10
Lipid composition varies among different cell types 11
Distribution of phospholipids and glycolipids in the lipid bilayer of human red blood cells
Some glycolipid molecules
Membrane Proteins
Secondary structure of protein
Amino acids with hydrophobic side chains
Hydrophobic amino acids in green and yellow
Predicting transmembrane helices from the amino acid sequence
Fraction of proteins (20 %) that span membranes
Secondary structure of protein
Examples of β-barrels
Detergent Micelle in Water
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Structures of Two Commonly Used Detergents
Liposome for studying membrane properties
Right side out vs. inside out depends on ionic conditions used during experiment
Distribution of phospholipids and glycolipids in the lipid bilayer of human red blood cells
Membrane Proteins in Human Red Blood Cells
Most Membrane Proteins have Structural Functions
Freeze Fracture Electron Microscopy
Band 3 can be seen as intramembrane particles, more on P face than E face
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