Genetics of Asthma International Network Sreekumar Pillai GlaxoSmithKline, Research and Development.

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Presentation transcript:

Genetics of Asthma International Network Sreekumar Pillai GlaxoSmithKline, Research and Development

Genetics of Asthma International Network (GAIN) l A multi-center nuclear family collection designed to study the genetics of asthma l 11 Centers in Europe, Australia, US and Barbados l Ascertained through an affected proband with physician’s diagnosis of asthma with at least one more sibling with asthma l 1018 families ascertained: DNA and phenotypic data available for ~4500 subjects

Progenitor Asthma Study l Samples collected by Mercator Genetics/ Progenitor l 3 Centers  Denmark: Jorgen Vestbo  Minnesota: Malcolm Blumenthal  Israel: Dror Harats

Asthma Family Collections SITE NAMEPrincipal Investigator Number of families Number of samples collected Progenitor Minnesotta, USDr.Malcolm Blumenthal DenmarkDr.Jorgen Vestbo IsraelDr.Dror Harats64512 GAIN Aberdeen, UKProf. Peter Helms Oslo, NorwayDr. Karin Carlsen Thessaloniki, Greece Dr. John Tsanakas Stoke-on-Trent, UKDr. Warren Lenney91396 Sheffield, UKDr. Moira Whyte99425 Perth, W. AustraliaDr. Peter Sly Leicester, UKProf. Michael Silverman87374 North Carolina, USDr. John Sundy64290 BarbadosDr. Kathleen Barnes Groningen, Netherlands Dr. Jorrit Gerritsen/ Dr.Gerard Koppelman Wesel, GermanyDr. Johannes Uekoetter Total

Demographic Characteristics (GAIN) VariableProbandsSiblings Males (%) Age at Ascertainment13.71 ± ± 5.03 Age of Onset 4.62 ± ± 4.08 FEV 1 (Lit)2.48 ± ± 0.99 IgE (IU) ± ± PC ± ± 13.75

Demographic Characteristics (Progenitor) DenmarkMinnesota Variable Siblings (n=563) Parents (n=588) Siblings (n=184) Parents (n=164) Age (Years) 28.10± ± ± ±0.63 Age of onset (Years)12.3± ± ± ±1.87 Gender (Females %) FEV 1 (Lit)3.48± ± ± ±0.07 FEV 1 Percent Predicted 91.91± ± ± ±1.41 Log 10 IgE2.2± ±0.05

Strengths l Family based study  All data points collected in children and parents l Multi-center collection  Large sample size l Same protocol used in all centers l Environmental exposure data l Lung function & Methacholine challenge tests l Atopy information (SPT and IgE) l Smoking history l Passive smoking history

Ongoing Collaborations l GABRIEL  Children from GAIN study included in GWAS l Channing (Scott Weiss)  Parents from UK families for GWAS

l GAIN Investigators l Progenitor Investigators Acknowledgements