The Avon Longitudinal Study of Parents and Children (ALSPAC): Children of the 90s Study Description.

Slides:

Advertisements

Similar presentations

ALSPAC clinics Larisa Duffy – Clinic Manager

Advertisements

Generation R Study Claudia Kruithof, MSc datamanager Generation R EUCCONET workshop june 2011 – Record Linkage.

An Overview Of The ALSPAC Data Resource RSS Avon Local Group Meeting 26 th May 2009 David Herrick

Gestational weight gain in a UK cohort: patterns, risk factors and associations with later mother and offspring health Debbie A Lawlor

National Diet and Nutrition Survey (NDNS) rolling programme

Matching PLASC and ALSPAC PLASC/NPD User Group Workshop 13 th September 2006 Andy Boyd David Herrick

Shared, child-specific and reciprocal influences in the development of psychopathology Jenny Jenkins, Judy Dunn, Jon Rasbash, Tom OConnor, Anna Simpson,

Potential for interventions in the early years to tackle health inequalities Karen MacNee Health ASD.

Record linkage in Birth cohort Biobanks Carel Thijs, Monique Mommers Maastricht University Biolink WP4 3 June, 2013.

Vivette Glover Imperial College London

Effectiveness of the National PMTCT Program in Rwanda

Neil Small, Professor of Health Research,

National Children’s Study University of New Mexico HSC & Valencia County Partnership 3X5X5 Signature Program in Child Health –July 15, 2008 Robert D Annett.

Pregnancy, Development and Birth

Perinatal Hepatitis B Prevention

School of Social and Community Medicine University of BRISTOL Environmental and genetic influences on childhood growth trajectories Laura D Howe.

Socioeconomic factors in relation to Autism Spectrum Disorders Dheeraj Rai and Selma Idring 17 March 2014

Environmental Risk Factors for Allergy Development in Children 1 Čižnár, P., 2 Reichrtov á, E., 2 Palkovi čová, Ľ., 3 McNabb, S.J.N., 3 Dunlop, A.L., 2.

1 ETS exposure of children  Respiratory diseases wheezing diminished pulmonary functions asthma bronchiale chronic bronchitis pneumonia  middle ear infections.

The Mother and Child Cohort in Crete, Rhea Study Study design & key findings Leda Chatzi, MD, PhD Department of Social Medicine, Faculty of Medicine, University.

Andreia Oliveira University of Porto Medical School, Dep. Clinical Epidemiology, Predictive Medicine and Public Health Institute of Public Health – University.

The British 1958 cohort (National Child Development Study)

Harmonisation between cohorts: Holy Grail or Fool’s errand.

Piama birth cohort Gerard H. Koppelman Pediatric Pulmonology and Pediatric Allergology Beatrix Children’s Hospital, University Medical Center Groningen,

Pregnancy Outcome Prediction Study University Department of Obstetrics and Gynaecology; PI – Professor Gordon CS Smith BACKGROUND The current pattern of.

Journal Club Alcohol and Health: Current Evidence May-June 2006.

Uses of Population Censuses and Household Sample Surveys for Vital Statistics in South Africa United Nations Expert Group Meeting on International Standards.

An example of using data from multiple longitudinal studies to address a scientific hypothesis: Maternal iron in pregnancy and offspring’s cardiovascular.

Born in Bradford Data Linkage David Bolus Head of Data Quality and Information Governance NHS Bradford and Airedale.

Frederica Perera, DrPH Professor, School of Public Health Director, Columbia Center for Children’s Environmental Health Mailman School of Public Health.

Avon Longitudinal Study of Parents and Children (ALSPAC) I4C Barcelona, Spain 2011 Update: Progress to date Cohort summary  Years of recruitment –

Inserm EDEN and ELFE mother-child cohorts Dietary assessment in infancy and early childhood.

Unintended Pregnancy West Virginia Melissa A. Baker, M.A. Office of Maternal, Child and Family Health WV Bureau for Public Health.

PMTCT Prevention of Mother to Child Transmission Version Aug 2011.

Examiners Mark Scheme Question 4 PAGE 1 Student A = 3 marks Question 4 PAGE 1 Student B = 2 marks Question 4i PAGE 1.

Material and methods Background and purpose For more information on The Norwegian Mother and Child Cohort Study go to :

Consult Research 27th April 2010 Supporting the Transition to Fatherhood: An Evaluation of HTGC in Staffordshire Claire Fraser Consult Research w:

The National Children’s Study Biospecimen Collections Mother – blood, urine, hair, nails, saliva, vaginal swab, breast milk Father – blood, urine, hair,

Early Genetics and Lifecourse Epidemiology (EAGLE) consortium CM van Duijn.

Four Settings and an Intervention: Why some work and others fail? Kamran Siddiqi, Department of Health Sciences, University of York Heather Thompson, Leeds.

Module II: Feeding and HIV Testing for Exposed Infants This module, we will discuss: Unit 1: Infant Feeding Guidelines Unit 2: HIV Testing and Treatment.

Japan Environment and Children’s Study (JECS) I4C Barcelona, Spain 2011 Update: Progress to date Cohort summary  Years of recruitment: January, 2011 –

Japan Environment and Children’s Study (Jecs). Jecs Longitudinal birth cohort study enrolling 100,000 pregnant women and following up their children until.

Andrew Smith Describing childhood diet with cluster analysis 6th September 2012.

Exposure of minority ethnic groups to second-hand smoke, in England Sarwat Shah Team: Kamran Siddiqi, Amanda Amos, Helen Tilbrook, Aziz Sheikh, Caroline.

MATERIAL & METHODS SECTION PREPARATION (IN THE HEALTH RESEARCH PROPOSAL) DR. HAYFAA A. WAHBI ASSISTANT PROFESSOR, CHAIR OF EBHC & KT COLLEGE OF MEDICINE.

GAIHN child health: supporting system integration Tim Jelleyman, Paediatrician, Waitemata District Health Board / GAIHN child health clinical lead & Louise.

Danish National Birth Cohort (DNBC) I4C_Lyon 2009 Methods and Data collection Population sample Years of recruitment: Sampling method:

A short introduction to epidemiology Chapter 2: Incidence studies Neil Pearce Centre for Public Health Research Massey University Wellington, New Zealand.

Testing the Gateway Behavior Strategy: Spouse Communication and Antenatal Counseling Catalyze a Lifetime of Family Health Douglas Storey, Grace Awantang,

Daniela Porta, Francesco Forastiere Rome, October 15th - 16th, 2012 POTENTIALS OF BIRTH COHORT STUDIES Maternal depression and stress in relation to childhood.

2015. The MoBa cohort Aim: To find causes of disease and factors involved in health related issues in a lifespan A large population based pregnancy cohort.

Infant Feeding Practices Study II Methods American Public Health Association November 5, 2007 Sara B. Fein, Judith Labiner-Wolfe, Katherine Shealy, Ruowei.

2015 Afghanistan Demographic and Health Survey (AfDHS) Key Indicators Report.

Factors associated with maternal smoking during early pregnancy: relationship to low-birth-weight infants and maternal attitude toward their pregnancy.

BACKGROUND Despite the well established link between fetal macrosomia and maternal diabetes, it is estimated that 80% of macrosomic babies are born to.

FROM RESEARCH TO POLICY ON INEQUALITIES IN HEALTH Michael Marmot International Centre for Health and Society University College London LONDON PUBLIC HEALTH.

Background A Change in Tradition Steady decline of marriage in the U.S. Increasing number of cohabiting unmarried couples - In 2000, 4.9 million opposite-sex.

Partner violence among young adults in the Philippines: The role of intergenerational transmission and gender Jessica A. Fehringer Michelle J. Hindin Department.

Adults living with HIV (15+) (thousands) [5] Children living with HIV (0-14) (thousands) [5] Pregnant.

Insert name of presentation on Master Slide Tackling Childhood Obesity in Wales – Public Health Wales supporting a system wide response Author: Dr Julie.

Life Factors. Different factors will effect an individuals development These factors will effect your chosen celebrity at some point Try to identify the.

Born In Bradford Neil Small Professor of Health Research School of Health Studies University of Bradford 25 Trinity Road, Bradford, BD5 OBB Tel:

CIFASD Progress Ukraine Clinical Project February 1-2, 2011

Research Proposal Data collection Components of the study

Section 1: What are longitudinal studies?

Questionnaire & physical exam

Pelotas Birth Cohort Study

The Preterm Birth Clinic Wellbeing Study

Presentation transcript:

The Avon Longitudinal Study of Parents and Children (ALSPAC): Children of the 90s Study Description

KEY FEATURES Population based Geographically defined Recruited during pregnancy Detailed follow-up, including hands-on measures Linked biological samples

All pregnant women resident in Avon Expected date of delivery 1.4.91-31.12.92 Recruited through antenatal clinics

RECRUITMENT 14,541 pregnancies (14,472 outcome known) 14,676 fetuses  14,062 live births 13,988 children alive at 1 year 542 children added at age 7 years 10% sample (Children in Focus) attended clinics 4 months - 5 years (n = 1,432)

ALSPAC Avon Rest of UK Owner-occupier 79.1 68.7 63.4 1+ person per room 33.5 26.0 30.8 Car in household 90.8 83.7 75.6 Married couple 79.4 71.7 71.8 Non-white mother 2.2 4.1 7.6

Cohort retention Age of child (months) 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% -10 10 20 30 40 50 60 70 80 90 Age of child (months)

4 questionnaires to mother in pregnancy DATA - QUESTIONNAIRES Questionnaires to: Mother about herself Mother’s partner Mother about Child 4 questionnaires to mother in pregnancy 6 months after birth and annual thereafter

DATA – HANDS-ON Children in Focus – 4m-5y Whole cohort – Annual clinics 7-15 years Current status – 17 year clinic running Multifaceted study of health, development and disease of children

Measures based on scientific priority (& cost) FOCUS AT 7 Eight sessions of 20 min Total clinic 2h 40min Measures based on scientific priority (& cost) 17+ clinic c.£3m M: Measures session A: Allergy session W: Word session C: Coordination session B1: First blood session B2: Second blood session V: Vision session H: Hearing session

Blood (most <5 y gone); later fasting blood for metabolic studies BIOLOGICAL SAMPLES DNA maternal, cord & 7y venous blood; transformed cell lines in progress DNA 10,000 mothers and children C. 1,000 partners Aim for 6,000 trios at end of current programme Blood (most <5 y gone); later fasting blood for metabolic studies Placentae, hair, teeth, urine (cotinine @ 8y and 15y)

ENVIRONMENT Mostly questionnaire based; but dating back to pregnancy Some small validation studies (NO2, salivary cortisols, etc.) Modelling pollution exposures Strengths: Diet (FFQ & diaries); Smoking; Pollution; Activity and body mass (accelerometers & DXA scans @ 9, 11, 13 years)

ASTHMA & ALLERGY Questionnaire data on wheezing, asthma, eczema & hay fever from 6m-17y Skin exam for eczema @ 5y (CiF) & 7y SPTs and total serum IgE @ 7y Spiro & BR methacholine @ 8y Spiro & FeNO & BD reversibility @ 15y

GWAS – CURRENT STATUS 1,400 samples Illumina 317k (WTCCC) 1,250 asthma case:control Illumina 610k (GABRIEL II) Expect asthma candidates on c.7,000 (GABRIEL Phase III) Applying for genome wide typing of whole cohort (?????)

http://www.bris.ac.uk/alspac