Membranes in Biology Rob Phillips California Institute of Technology (McMahon)

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Presentation transcript:

Membranes in Biology Rob Phillips California Institute of Technology (McMahon)

Cells and Their Membranes

Lipids

Lipid Bilayers (In Vitro) Hydrophobic tails and polar head groups. Favorable for lipids to spontaneously assemble to form bilayers. MolecularContinuum (Avanti Polar Lipids)

Membranes In Vivo Real biological membranes contain many different lipids & transmembrane proteins!

The Complexity of Real-World Membranes

The Motility of Proteins in Membranes

Membrane Deformation in Biology (McMahon)

Membrane Deformation in Biology (McMahon)

Quantitative Tools for Tomography: Viral Budding as an Example Tomography producing wide range of images of deformed membrane systems. Calculated Deformation of Vesicle Due to Actin Polymerization (Medalia et al.) Observed Membrane Deformation During Cell Movement (Dooher et al.) HIV Budding

Vesicle Transport

Vesicle Transport: Clathrin Coating

Dynamin and Vesicle Fission (McMahon)

Ion Channels and Transient Permeability Channels open in response to a variety of different stimuli. Key mechanisms are voltage gating, ligand binding- induced gating and mechanical tension in the membrane.

Physics of Viral Budding ( )