FGF Receptor 3 …and its role in Bladder Cancer Jenny Espinosa Biology 169 March 30, 2004 What is it?

Slides:

Advertisements

Similar presentations

1 LAMININE (YTF, OPTI-9, PTSE) Steven P. Petrosino, Ph.D., FACAM, MARHP Gold Director LifePharm, Inc.

Advertisements

Embryology Behrouz Mahmoudi Molecular Signaling 1.

Coordination of cellular-fate processes

Structural Basis for Ligand- Receptor Recognition and Dimerization Moosa Mohammadi Dept. of Pharmacology Medical Science Building, 4th Floor, Rooms 425,

BMP Receptor 1 : Juvenile Polyposis (Colon Cancer) Cecily Johnson Biology 169 March 24, 2005.

NF2: A Tumor Suppressor NF2 encodes Merlin/Schwannomin, a protein that regulates cell growth and proliferation.

C-Kit and Gastrointestinal Stromal Tumors By Jessica Danielle Stewart

ZAFIA ANKLESARIA Role of BMPR1A in Juvenile Polyposis Syndrome Biology 169.

Controlling a Killer Malfunction By: Brady Sebo, Tom Fish, Addela Marzofka, and Colton Cummings

Notch1 and its role in pre T-cell Acute Lymphoblastic Leukemia (ALL) By Rebecca Goodman.

PDGF β Receptor. Protein 1106 amino acid protein Weinberg Fig 5.10.

Transforming Growth Factor-Beta Receptor 2 TGF-β receptor 2

Colony-Stimulating Factor Receptor (CSF-1R); c-fms.

Chapter 20 oncogene, anti-oncogene and growth factor The biochemistry and molecular biology department of CMU.

RET Proto- Oncogene in The Development of Thyroid Cancer: Multiple Endocrine Neoplasia Type 2 Courtney Brooks.

Natural History of Achondroplasia Autosomal Dominant Gene Mutation.

Oncogenes and tumour suppressor genes 1. Cancer mutations occur in two forms.

Regulation of the Cell Cycle. Molecular Control System Normal growth, development and maintenance depend on the timing and rate of mitosis Cell-cycle.

Achondroplasia Aswad Habeeb Hameed Al-Obeidy FICMS GE & Hep.

Sef Inhibits Fibroblast Growth Factor Signaling by Inhibiting FGFR1 Tyrosine Phosphorylation and Subsequent ERK Activation Authors: Dmitry Kovalenko, Xuehoi.

Kyoto University, Japan

Cancer --an Overview  Cell Division  Hormones and Cancer  Malignant Transformation  Angiogenesis and Metastasis  Growth.

Signal Transduction Mechanisms

Regulation of cell function by FGFR3 receptor tyrosine kinase

Characteristics of Cancer. Promotion (reversible) Initiation (irreversible) malignant metastases More mutations Progression (irreversible)

Developmental Genetics Dr. E. M. Honey Department Genetics University of Pretoria.

Fibroblast Growth Factor receptor 3 Mutations in Epidermal Nevi and Associated Low Grade l Bladder Tumors. Hernandez S, Toll A et al JID (2007, July),

Achondroplasia: Dwarfism Kelly LaBarre. Clinical Features Achondroplasia literally means “without cartilage formation.” Presents clinically as a long.

FGFR3 and Bladder Cancer Amy Fair March 29, 2005 Biol 169.

oncogene, anti-oncogene and growth factor

Understanding Cancer and Related Topics

Gene Sleuthing Lorraine Sartori Majid Masso Paul R. McCreary.

Cell Growth & Differentiation Vol. 10, , 1999 Inhibition of the Jun Kinase Pathway Blocks DNA Repair, Enhances p53-mediated Apoptosis and Promotes.

 Signaling molecules that function within an organism to control metabolic processes within cells, the growth and differentiation of tissues, the synthesis.

Fibroblast Growth Factors (FGFs)

BMP receptor1A Presented by Jena Buchan

Tyrosine Kinases as Targets for Cancer Therapy Krause DS, Van Etten RA N Engl J Med 2005;353(2): Krause DS, Van Etten RA N Engl J Med 2005;353(2):

REGULATION OF LIMB DEVELOPMENT BY FIBROBLAST GROWTH FACTOR (FGF) SYSTEM Pavel Krejci.

Negative regulation of cell cycle by intracellular signals Checkpoint p53 detects DNA damage & activates p21 p21 inhibits cdk2-cyclinA Intracellular Regulation.

PTEN (Phosphatase and Tensin Homolog) a.k.a. MMAC1, TEP1 Raymond Stadiem.

5. Cytokine 细胞因子王家鑫，孟明 Department of Veterinary Immunology College of Animal Science and Technology Agricultural University of Hebei.

Pathology 430/827 Bladder cancer Etiology, classification, and diversity David M. Berman, MD, PhD Pathology and Molecular Medicine Queen’s Cancer Research.

Lung Cancer Tumour Markers

Measurement of the p38 signaling pathway in the Pro253Arg mutation of FGFR2 in Apert syndrome Kaivalya Dandamudi.

Measurement of the p38 signaling pathway in the Pro253Arg mutation of FGFR2 in Apert syndrome Kaivalya Dandamudi.

Figure 1. Resistance mechanism against first generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). (A) Mutations in the EGFR.

Growth factors Polypeptides in nature

Signal transduction Cellular response

Inducing Angiogenesis

Inhibition of FGFR fusion kinase activity repressed tumor growth in a mouse xenograft model. Inhibition of FGFR fusion kinase activity repressed tumor.

Fibroblast Growth Factor 3 (FGF3) int-2

Rethinking bioactivity of FLT3 inhibitors

M.B.Ch.B, MSC, DCH (UK), MRCPCH

c-Kit as a Novel Potential Therapeutic Target in Colorectal Cancer

Cell to Cell Communication via Enzyme Linked Receptors

Oncogenes and tumour suppressor genes

Notch1 and its role in pre-T-cell acute lymphoblastic leukemia (T-ALL)

A Jagged Road to Lymphoma Aggressiveness

Development of PI3K/AKT/mTOR Pathway Inhibitors and Their Application in Personalized Therapy for Non–Small-Cell Lung Cancer Vassiliki Papadimitrakopoulou,

Platelet-derived growth factor receptors (PDGFRs) and ligand patterns.

A Novel Skeletal Dysplasia with Developmental Delay and Acanthosis Nigricans Is Caused by a Lys650Met Mutation in the Fibroblast Growth Factor Receptor.

Kenneth E. White, Jose M. Cabral, Siobhan I

BMP Receptor 1a and Juvenile Polyposis Syndrome

TGF-β Receptor I/ ALK-5 and Pancreatic and Biliary Cancer

M.B.Ch.B, MSC, PhD, DCH (UK), MRCPCH

Masaru Katoh Journal of Investigative Dermatology

Proposed model of mandibular dysmorphogenesis in prenatal development of Fgfr2+/S252W mice. Proposed model of mandibular dysmorphogenesis in prenatal development.

The new kid on the block(ade) of the IGF-1 receptor

Notch signaling from tumor cells: A new mechanism of angiogenesis

Presentation transcript:

FGF Receptor 3 …and its role in Bladder Cancer Jenny Espinosa Biology 169 March 30, 2004 What is it?

Just what is FGFR3 anyway? Fibroblast Growth Factor Receptor 3  Receptor Tyrosine Kinase  Glycoprotein Contains extracellular immunoglobulin domains, a hydrophobic transmembrane domain, & a split tyrosine- kinase domain Two isoforms: FGFR3b and FGFR3c Found in the plasma membrane

Normally found in: Rat Zebrafish Mouse Frog Fruitfly As well as in…

US!!

So what does it do?? Michiyuki Kanai, Mchael Goke, Shoji Tsunekawa and Daniel Podolsky

Yeah, but what does it really do?! Involved in a developmental pathway Negative regulator of bone growth Promotion & inhibition of chondrocyte proliferation and differentiation (mouse) Regulation of epithelial cell growth & differentiation Involved in embryogenesis, angiogenesis, and wound healing Main point here… REGULATION OF CELL PROLIFERATION AND DIFFERENTIATION

FGFR extracellular domain FGFR intracellular domain David M. Ornitz & Pierre J. Marie Hmm… what happens then if the cell is mutated? - Achondroplasia* - Thanatophoric dysplasia* - Non-syndromic cranial synostosis - Crouzonodermoskeletal syndrome - Hypochondroplasia*

Effects of activated FGFR3 in Mice

What role does it play in CANCER ??

FGFR3 and Bladder Cancer

Bladder Cancer –s–s–s–somatic mutation in bladder carcinomas (superficial or low-grade) –(–(–(–(74%) in non-invasive papillary tumors –a–a–a–absence of mutations in carcinoma in situ –r–r–r–recurrence more frequent in wild type FGFR3

That’s all folks!